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Intra-arterial urokinase infusion in the very early stage of cerebral artery occlusion and stenosis at their main trunks

Journal Article:

Abstract

Eight patients, aged 43 approx. 78 years, with occlusion or stenosis of intracranial cerebral arteries at their main trunks were treated with intraarterial urokinase infusion within 5 hours after onset. Intracranial hemorrhage was excluded and low density area were absent on the first CT examination. Three of eight patients were diagnosed as embolism because of the sudden onset and coexisted atrial fibrillation. Middle cerebral artery (MCA) occlusion was disclosed in 5 cases. MCA stenosis, internal carotid artery (ICA) occlusion and ICA stenosis were revealed in each one case by angiography. 24 approx. 72 x 10/sup 4/ units of urokinase was infused manually into the common or internal carotid artery through the catheter for angiography within 10 approx. 50 minutes. Anticoagulants were not used exept in one case. Four patients were immediately improved after urokinase infusion and discharged without any significant sequelae. Patients with mild or moderate disability due to thrombosis recovered and those with severe symptoms due to embolism scarcely improved. The follow-up CT scans revealed hemorragic infarction in only one case (embolism of MCA), although symptoms did not deteriorate. After infusion of 48 x 10/sup 4/ units of urokinase for 50 minutes, fibrinogen and ..cap alpha../sub 2/-antiplasmin (..cap alpha../sub  More>>
Authors:
Publication Date:
Feb 01, 1988
Product Type:
Journal Article
Reference Number:
JPN-88-074254; EDB-88-107246
Resource Relation:
Journal Name: No Sotchu; (Japan); Journal Volume: 10:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CAROTID ARTERIES; BIOMEDICAL RADIOGRAPHY; UROKINASE; CAT SCANNING; CEREBRUM; CHEMOTHERAPY; PATIENTS; THROMBOSIS; VASCULAR DISEASES; VASOCONSTRICTION; ARTERIES; BLOOD VESSELS; BODY; BRAIN; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ENZYMES; FIBRINOLYTIC AGENTS; HEMATOLOGIC AGENTS; HYDROLASES; MEDICINE; NERVOUS SYSTEM; NONSPECIFIC PEPTIDASES; NUCLEAR MEDICINE; ORGANS; PEPTIDE HYDROLASES; RADIOLOGY; THERAPY; TOMOGRAPHY; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
5136292
Research Organizations:
Hamamatsu University School of Medicine, Shizuoka (Japan)
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NOSOD
Submitting Site:
JPN
Size:
Pages: 85-93
Announcement Date:

Journal Article:

Citation Formats

Shizume, Kengo. Intra-arterial urokinase infusion in the very early stage of cerebral artery occlusion and stenosis at their main trunks. Japan: N. p., 1988. Web.
Shizume, Kengo. Intra-arterial urokinase infusion in the very early stage of cerebral artery occlusion and stenosis at their main trunks. Japan.
Shizume, Kengo. 1988. "Intra-arterial urokinase infusion in the very early stage of cerebral artery occlusion and stenosis at their main trunks." Japan.
@misc{etde_5136292,
title = {Intra-arterial urokinase infusion in the very early stage of cerebral artery occlusion and stenosis at their main trunks}
author = {Shizume, Kengo}
abstractNote = {Eight patients, aged 43 approx. 78 years, with occlusion or stenosis of intracranial cerebral arteries at their main trunks were treated with intraarterial urokinase infusion within 5 hours after onset. Intracranial hemorrhage was excluded and low density area were absent on the first CT examination. Three of eight patients were diagnosed as embolism because of the sudden onset and coexisted atrial fibrillation. Middle cerebral artery (MCA) occlusion was disclosed in 5 cases. MCA stenosis, internal carotid artery (ICA) occlusion and ICA stenosis were revealed in each one case by angiography. 24 approx. 72 x 10/sup 4/ units of urokinase was infused manually into the common or internal carotid artery through the catheter for angiography within 10 approx. 50 minutes. Anticoagulants were not used exept in one case. Four patients were immediately improved after urokinase infusion and discharged without any significant sequelae. Patients with mild or moderate disability due to thrombosis recovered and those with severe symptoms due to embolism scarcely improved. The follow-up CT scans revealed hemorragic infarction in only one case (embolism of MCA), although symptoms did not deteriorate. After infusion of 48 x 10/sup 4/ units of urokinase for 50 minutes, fibrinogen and ..cap alpha../sub 2/-antiplasmin (..cap alpha../sub 2/ AP) decreased to 34 % and 21 % of the original values, respectively. Although the decrease of fibrinogen level is a disadvantage in this therapy, the decrease in the level of ..cap alpha../sub 2/ AP near the clot is probably indispensable for the fibrinolytic effect. If the endothelial damage of ischemic arteries still remain mild and reversible, hemorrhagic complication after reperfusion may rarely take place. It is suggested that intraarterial urokinase infusion is a relatively safe and effective therapy of cerebral artery occlusion and stenosis in strictly selected cases.}
journal = {No Sotchu; (Japan)}
volume = {10:1}
journal type = {AC}
place = {Japan}
year = {1988}
month = {Feb}
}