Abstract
Between August 1985 and October 1987 35 patients with chronic myeloid leukaemia (CML) were treated by high dose chemotherapy, total body irradiation (TBI) (1000 or 1200 cGy, n=31) and total lymphoid irradiation (TLI) (800 or 600 cGy, n=35) preceding allogeneic bone marrow transplantation (BMT). Both TBI and TLI were given at 200 cGy/fraction. Twenty-three patients had HLA-identical sibling donors, nine patients had HLA-matched but unrelated donors, and three partially HLA-mismatched donors. Twenty-two patients received T-cell depleted marrow. TLI did not add greatly to the toxicity. Four patients had recurrent leukaemia before engraftment was evaluable. The other 31 patients engrafted and no graft failed. Twenty-two patients survive at a median time from transplant of 305 days (range 81-586 days). Fourteen have no evidence of disease; eight have or had only cytogenetic evidence of leukaemia. It is concluded that addition of TLI to pretransplant immunosuppression increases the probability of reliable engraftment in patients receiving T-cell depleted marrow. This is not associated with significantly increased toxicity. (author).
James, N D;
Apperley, J F;
Kam, K C;
Mackinnon, S;
Goldman, J M;
Goolden, A W.G.;
Sikora, K
[1]
- Royal Postgraduate Medical School, London (UK)
Citation Formats
James, N D, Apperley, J F, Kam, K C, Mackinnon, S, Goldman, J M, Goolden, A W.G., and Sikora, K.
Total lymphoid irradiation preceding bone marrow transplantation for chronic myeloid leukaemia.
United Kingdom: N. p.,
1989.
Web.
doi:10.1016/S0009-9260(89)80094-7.
James, N D, Apperley, J F, Kam, K C, Mackinnon, S, Goldman, J M, Goolden, A W.G., & Sikora, K.
Total lymphoid irradiation preceding bone marrow transplantation for chronic myeloid leukaemia.
United Kingdom.
https://doi.org/10.1016/S0009-9260(89)80094-7
James, N D, Apperley, J F, Kam, K C, Mackinnon, S, Goldman, J M, Goolden, A W.G., and Sikora, K.
1989.
"Total lymphoid irradiation preceding bone marrow transplantation for chronic myeloid leukaemia."
United Kingdom.
https://doi.org/10.1016/S0009-9260(89)80094-7.
@misc{etde_5130037,
title = {Total lymphoid irradiation preceding bone marrow transplantation for chronic myeloid leukaemia}
author = {James, N D, Apperley, J F, Kam, K C, Mackinnon, S, Goldman, J M, Goolden, A W.G., and Sikora, K}
abstractNote = {Between August 1985 and October 1987 35 patients with chronic myeloid leukaemia (CML) were treated by high dose chemotherapy, total body irradiation (TBI) (1000 or 1200 cGy, n=31) and total lymphoid irradiation (TLI) (800 or 600 cGy, n=35) preceding allogeneic bone marrow transplantation (BMT). Both TBI and TLI were given at 200 cGy/fraction. Twenty-three patients had HLA-identical sibling donors, nine patients had HLA-matched but unrelated donors, and three partially HLA-mismatched donors. Twenty-two patients received T-cell depleted marrow. TLI did not add greatly to the toxicity. Four patients had recurrent leukaemia before engraftment was evaluable. The other 31 patients engrafted and no graft failed. Twenty-two patients survive at a median time from transplant of 305 days (range 81-586 days). Fourteen have no evidence of disease; eight have or had only cytogenetic evidence of leukaemia. It is concluded that addition of TLI to pretransplant immunosuppression increases the probability of reliable engraftment in patients receiving T-cell depleted marrow. This is not associated with significantly increased toxicity. (author).}
doi = {10.1016/S0009-9260(89)80094-7}
journal = []
volume = {40:2}
journal type = {AC}
place = {United Kingdom}
year = {1989}
month = {Mar}
}
title = {Total lymphoid irradiation preceding bone marrow transplantation for chronic myeloid leukaemia}
author = {James, N D, Apperley, J F, Kam, K C, Mackinnon, S, Goldman, J M, Goolden, A W.G., and Sikora, K}
abstractNote = {Between August 1985 and October 1987 35 patients with chronic myeloid leukaemia (CML) were treated by high dose chemotherapy, total body irradiation (TBI) (1000 or 1200 cGy, n=31) and total lymphoid irradiation (TLI) (800 or 600 cGy, n=35) preceding allogeneic bone marrow transplantation (BMT). Both TBI and TLI were given at 200 cGy/fraction. Twenty-three patients had HLA-identical sibling donors, nine patients had HLA-matched but unrelated donors, and three partially HLA-mismatched donors. Twenty-two patients received T-cell depleted marrow. TLI did not add greatly to the toxicity. Four patients had recurrent leukaemia before engraftment was evaluable. The other 31 patients engrafted and no graft failed. Twenty-two patients survive at a median time from transplant of 305 days (range 81-586 days). Fourteen have no evidence of disease; eight have or had only cytogenetic evidence of leukaemia. It is concluded that addition of TLI to pretransplant immunosuppression increases the probability of reliable engraftment in patients receiving T-cell depleted marrow. This is not associated with significantly increased toxicity. (author).}
doi = {10.1016/S0009-9260(89)80094-7}
journal = []
volume = {40:2}
journal type = {AC}
place = {United Kingdom}
year = {1989}
month = {Mar}
}