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Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system

Journal Article:

Abstract

Haloperidol was chosen as a model compound to determine whether the degradation products created by sterilizing dose of gamma radiation would contaminate an implantible delivery device and be hazardous to the health of the person using it. Acrolein, chlorobenzene, and several other products were identified among the degradation products. They were quantitated and evaluated as being potentially dangerous. It is recommended that the development protocol for a radiation-sterilized, implantible drug include the identification and evaluation of the degradation products.
Authors:
Publication Date:
Jan 01, 1988
Product Type:
Journal Article
Reference Number:
AIX-19-057849; EDB-88-104589
Resource Relation:
Journal Name: Pharmazie; (Germany, Federal Republic of); Journal Volume: 43:1
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; TRANQUILIZERS; DECOMPOSITION; RADIOSTERILIZATION; GAMMA RADIATION; IMPLANTS; CENTRAL NERVOUS SYSTEM AGENTS; CHEMICAL REACTIONS; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; PSYCHOTROPIC DRUGS; RADIATIONS; STERILIZATION; 400600* - Radiation Chemistry
OSTI ID:
5128860
Research Organizations:
Analytical Research Lab., Kimberly-Clark Corp., Neenah, WI (USA)
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PHARA
Submitting Site:
INIS
Size:
Pages: 31-32
Announcement Date:
Jun 01, 1988

Journal Article:

Citation Formats

Booker, J. Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system. Germany: N. p., 1988. Web.
Booker, J. Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system. Germany.
Booker, J. 1988. "Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system." Germany.
@misc{etde_5128860,
title = {Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system}
author = {Booker, J}
abstractNote = {Haloperidol was chosen as a model compound to determine whether the degradation products created by sterilizing dose of gamma radiation would contaminate an implantible delivery device and be hazardous to the health of the person using it. Acrolein, chlorobenzene, and several other products were identified among the degradation products. They were quantitated and evaluated as being potentially dangerous. It is recommended that the development protocol for a radiation-sterilized, implantible drug include the identification and evaluation of the degradation products.}
journal = {Pharmazie; (Germany, Federal Republic of)}
volume = {43:1}
journal type = {AC}
place = {Germany}
year = {1988}
month = {Jan}
}