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Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life

Journal Article:

Abstract

A human foetus was heavily irradiated in the thirtieth to the thirty-third week due to carcinoma of the uterine cervix of the mother. Irradiation after 20 weeks of pregnancy is thought not to produce severe abnormalities. However, the child showed microcephaly, mental retardation, stunted growth, microphthalmus, retinal degeneration, cataract and defective dentition. Cytogenetically the frequencies of both chromatid and chromosome breaks were increased.
Authors:
Gustavson, K H; Jagell, S; Blomquist, H K; Nordenson, I [1] 
  1. Umeaa Univ. (Sweden)
Publication Date:
Jan 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-677786; EDB-82-146806
Resource Relation:
Journal Name: Acta Radiol., Oncol., Radiat. Ther., Phys. Biol.; (Sweden); Journal Volume: 20:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; FETUSES; BIOLOGICAL RADIATION EFFECTS; BRAIN; CARCINOMAS; CHILDREN; CHROMOSOMAL ABERRATIONS; FEMALES; MALFORMATIONS; MENTAL DISORDERS; PREGNANCY; PRENATAL IRRADIATION; RADIATION DOSES; RADIOTHERAPY; UROGENITAL SYSTEM DISEASES; UTERUS; AGE GROUPS; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; DOSES; FEMALE GENITALS; IRRADIATION; MEDICINE; MUTATIONS; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; PRENATAL EXPOSURE; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5102363
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AROBD
Submitting Site:
HEDB
Size:
Pages: 209-212
Announcement Date:

Journal Article:

Citation Formats

Gustavson, K H, Jagell, S, Blomquist, H K, and Nordenson, I. Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life. Sweden: N. p., 1981. Web.
Gustavson, K H, Jagell, S, Blomquist, H K, & Nordenson, I. Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life. Sweden.
Gustavson, K H, Jagell, S, Blomquist, H K, and Nordenson, I. 1981. "Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life." Sweden.
@misc{etde_5102363,
title = {Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life}
author = {Gustavson, K H, Jagell, S, Blomquist, H K, and Nordenson, I}
abstractNote = {A human foetus was heavily irradiated in the thirtieth to the thirty-third week due to carcinoma of the uterine cervix of the mother. Irradiation after 20 weeks of pregnancy is thought not to produce severe abnormalities. However, the child showed microcephaly, mental retardation, stunted growth, microphthalmus, retinal degeneration, cataract and defective dentition. Cytogenetically the frequencies of both chromatid and chromosome breaks were increased.}
journal = {Acta Radiol., Oncol., Radiat. Ther., Phys. Biol.; (Sweden)}
volume = {20:3}
journal type = {AC}
place = {Sweden}
year = {1981}
month = {Jan}
}