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N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease

Journal Article:

Abstract

Eighteen patients with Alzheimer's disease (AD), 5 patients with Pick disease (PD), 6 patients with other types of degenerative dementia (O) and 12 age-matched normal control subjects (N) were studied using N-isopropyl p-(I-123)iodoamphetamine (I-123 IMP) with SPECT. Regional to cerebellar activity (R/CE) ratio and frontal to parietal (F/R) activity ratio were evaluated in each case. I-123 IMP-SPECT revealed focal abnormality in all cases in AD, PD, O group, while XCT and/or MRI were normal or showed cerebral atrophy without focal abnormal density or intensity. In AD group, R/CE ratio in all the regions except for bilateral Rolandic area and left primary visual cortex were significantly lower (p<0.05 or p<0.01) than that in N group, and F/P ratio were significantly higher (p<0.01) than that in P and O group. In conclusion, I-123 IMP-SPECT is useful to detect focal perfusion abnormality in dementia and may be of value in differentiating Alzheimer's disease from dementia of non-Alzheimer type. (author).
Authors:
Momose, Toshimitsu; Nishikawa, Junichi; Kosaka, Noboru; Ohtake, Tohru; Watanabe, Toshiaki; Yoshikawa, Kohki; Iio, Masahiro [1] 
  1. Tokyo Univ. (Japan). Faculty of Medicine
Publication Date:
Sep 01, 1989
Product Type:
Journal Article
Reference Number:
JPN-89-015281; EDB-90-028861
Resource Relation:
Journal Name: Kaku Igaku; (Japan); Journal Volume: 26:9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; BENZEDRINE; BLOOD FLOW; CAT SCANNING; IMAGES; MENTAL DISORDERS; NMR IMAGING; PATIENTS; REFERENCE MAN; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5101541
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0022-7854; CODEN: KAIGB
Submitting Site:
JPN
Size:
Pages: 1177-1192
Announcement Date:
Feb 15, 1990

Journal Article:

Citation Formats

Momose, Toshimitsu, Nishikawa, Junichi, Kosaka, Noboru, Ohtake, Tohru, Watanabe, Toshiaki, Yoshikawa, Kohki, and Iio, Masahiro. N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease. Japan: N. p., 1989. Web.
Momose, Toshimitsu, Nishikawa, Junichi, Kosaka, Noboru, Ohtake, Tohru, Watanabe, Toshiaki, Yoshikawa, Kohki, & Iio, Masahiro. N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease. Japan.
Momose, Toshimitsu, Nishikawa, Junichi, Kosaka, Noboru, Ohtake, Tohru, Watanabe, Toshiaki, Yoshikawa, Kohki, and Iio, Masahiro. 1989. "N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease." Japan.
@misc{etde_5101541,
title = {N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease}
author = {Momose, Toshimitsu, Nishikawa, Junichi, Kosaka, Noboru, Ohtake, Tohru, Watanabe, Toshiaki, Yoshikawa, Kohki, and Iio, Masahiro}
abstractNote = {Eighteen patients with Alzheimer's disease (AD), 5 patients with Pick disease (PD), 6 patients with other types of degenerative dementia (O) and 12 age-matched normal control subjects (N) were studied using N-isopropyl p-(I-123)iodoamphetamine (I-123 IMP) with SPECT. Regional to cerebellar activity (R/CE) ratio and frontal to parietal (F/R) activity ratio were evaluated in each case. I-123 IMP-SPECT revealed focal abnormality in all cases in AD, PD, O group, while XCT and/or MRI were normal or showed cerebral atrophy without focal abnormal density or intensity. In AD group, R/CE ratio in all the regions except for bilateral Rolandic area and left primary visual cortex were significantly lower (p<0.05 or p<0.01) than that in N group, and F/P ratio were significantly higher (p<0.01) than that in P and O group. In conclusion, I-123 IMP-SPECT is useful to detect focal perfusion abnormality in dementia and may be of value in differentiating Alzheimer's disease from dementia of non-Alzheimer type. (author).}
journal = {Kaku Igaku; (Japan)}
volume = {26:9}
journal type = {AC}
place = {Japan}
year = {1989}
month = {Sep}
}