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Autoradiographic studies of the protein metabolism and histochemical demonstration of the zinc content of the brain in diabetic rats. 1. Streptozotocin-induced diabetes

Journal Article:

Abstract

Diabetes mellitus was induced in rats by application of streptozotocin: 40 mg/kg body weight streptozotocin produced a fairly serious diabetes with minimal ketosis, 125 mg/kg body weight streptozotocin caused a severe diabetic keto-acidosis. After 72 hours these animals and also a group of control animals received 308 MBq/animal /sup 3/H-leucine intraperitoneally. By means of stripping film autoradiograms the rates of uptake of /sup 3/H-leucine in different areas of the rat brain were measured. The values of the control animals were compared with those of a fairly serious diabetes and those of a severe diabetic keto-acidosis. In the regions of the neocortex parietalis and of the thalamus the /sup 3/H-leucine values of the diabetic animals were considerably lower in comparison with the controls, and that irrespective of the degree of severity of the diabetic disease. Compared with the control animals the /sup 3/H-leucine values as well as the zinc content of diabetic animals decreased according to the degree of severity of the disease within the Ammon's horn and the dentate fascia. The particular significance of the Ammon's horn and the dentate fascia concerning diabetic metabolic conditions was discussed.
Authors:
Gatzke, H D; [1]  Wildmeister, W [2] 
  1. Freie Univ. Berlin (Germany, F.R.)
  2. Krankenhaus Kempen (Germany, F.R.). Innere Klinik
Publication Date:
Nov 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-552214; EDB-80-113134
Resource Relation:
Journal Name: Endokrinologie; (German Democratic Republic); Journal Volume: 74:3
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; AUTORADIOGRAPHY; DIABETES MELLITUS; BIOLOGICAL EFFECTS; LEUCINE; METABOLISM; ZINC COMPOUNDS; TISSUE DISTRIBUTION; ANTIBIOTICS; COMPARATIVE EVALUATIONS; HISTOLOGICAL TECHNIQUES; NITROSO COMPOUNDS; PROTEINS; RADIONUCLIDE KINETICS; RATS; SACCHARIDES; THALAMUS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ZINC 65; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE DISEASES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; VERTEBRATES; ZINC ISOTOPES; 550901* - Pathology- Tracer Techniques
OSTI ID:
5099994
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: ENDKA
Submitting Site:
INIS
Size:
Pages: 323-346
Announcement Date:

Journal Article:

Citation Formats

Gatzke, H D, and Wildmeister, W. Autoradiographic studies of the protein metabolism and histochemical demonstration of the zinc content of the brain in diabetic rats. 1. Streptozotocin-induced diabetes. Germany: N. p., 1979. Web.
Gatzke, H D, & Wildmeister, W. Autoradiographic studies of the protein metabolism and histochemical demonstration of the zinc content of the brain in diabetic rats. 1. Streptozotocin-induced diabetes. Germany.
Gatzke, H D, and Wildmeister, W. 1979. "Autoradiographic studies of the protein metabolism and histochemical demonstration of the zinc content of the brain in diabetic rats. 1. Streptozotocin-induced diabetes." Germany.
@misc{etde_5099994,
title = {Autoradiographic studies of the protein metabolism and histochemical demonstration of the zinc content of the brain in diabetic rats. 1. Streptozotocin-induced diabetes}
author = {Gatzke, H D, and Wildmeister, W}
abstractNote = {Diabetes mellitus was induced in rats by application of streptozotocin: 40 mg/kg body weight streptozotocin produced a fairly serious diabetes with minimal ketosis, 125 mg/kg body weight streptozotocin caused a severe diabetic keto-acidosis. After 72 hours these animals and also a group of control animals received 308 MBq/animal /sup 3/H-leucine intraperitoneally. By means of stripping film autoradiograms the rates of uptake of /sup 3/H-leucine in different areas of the rat brain were measured. The values of the control animals were compared with those of a fairly serious diabetes and those of a severe diabetic keto-acidosis. In the regions of the neocortex parietalis and of the thalamus the /sup 3/H-leucine values of the diabetic animals were considerably lower in comparison with the controls, and that irrespective of the degree of severity of the diabetic disease. Compared with the control animals the /sup 3/H-leucine values as well as the zinc content of diabetic animals decreased according to the degree of severity of the disease within the Ammon's horn and the dentate fascia. The particular significance of the Ammon's horn and the dentate fascia concerning diabetic metabolic conditions was discussed.}
journal = {Endokrinologie; (German Democratic Republic)}
volume = {74:3}
journal type = {AC}
place = {Germany}
year = {1979}
month = {Nov}
}