You need JavaScript to view this

Study of subcellular distribution of /sup 169/Yb and /sup 111/In in tumor and liver

Journal Article:

Abstract

Rats were implanted with Yoshida sarcoma and hepatoma AH109A; and mice were implanted with Ehrlich tumor. /sup 169/Yb-citrate and /sup 111/In-citrate were injected into the rats intravenously and into the mice intraperitoneally. Ten minutes to 48 hours after the administration of /sup 169/Yb-citrate and /sup 111/In-citrate, the animals were sacrificed and the tumor tissues and liver were excised. Subcellular fractionation of tumor tissues and liver was carried out according to the method of Hogeboom and Schneider. The /sup 169/Yb and /sup 111/In of each fraction were counted by a well type scintillation counter, and the protein of each fraction was measured according to Lowry's method. In Yoshida sarcoma and Ehrlich tumor, most of the radioactivity was localized in the supernatant fraction, and a small amount of radioactivity was accumulated in the mitochondrial fraction (lysosome is contained in this fraction). But, in the liver, most of the radioactivity was concentrated in the mitochondrial fraction, and the radioactivity of this fraction was increased with the passage of time after administration. Twenty-four hours later, about 50% of the total radioactivity was accumulated in this fraction. In the case of hepatoma AH109A, radioactivity of the mitochondrial fraction was increased with time after administration, and  More>>
Authors:
Ando, A; Takeshita, M; Hiraki, T; [1]  Ando, Itsuko; Hisada, Kinichi
  1. Kanazawa Univ. (Japan). School of Paramedicine
Publication Date:
Mar 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-349775; EDB-78-070974
Resource Relation:
Journal Name: Radioisotopes (Tokyo); (Japan); Journal Volume: 26:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EHRLICH ASCITES TUMOR; RADIONUCLIDE KINETICS; HEPATOMAS; INDIUM 111; BIOLOGICAL LOCALIZATION; LIVER; SARCOMAS; YTTERBIUM 169; CITRATES; LYSOSOMES; MICE; MITOCHONDRIA; RATS; UPTAKE; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACID SALTS; CELL CONSTITUENTS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; EXPERIMENTAL NEOPLASMS; GLANDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANOIDS; ORGANS; RADIOISOTOPES; RARE EARTH ISOTOPES; RARE EARTH NUCLEI; RODENTS; VERTEBRATES; YTTERBIUM ISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
5087330
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: RAISA
Submitting Site:
INIS
Size:
Pages: 169-174
Announcement Date:

Journal Article:

Citation Formats

Ando, A, Takeshita, M, Hiraki, T, Ando, Itsuko, and Hisada, Kinichi. Study of subcellular distribution of /sup 169/Yb and /sup 111/In in tumor and liver. Japan: N. p., 1977. Web.
Ando, A, Takeshita, M, Hiraki, T, Ando, Itsuko, & Hisada, Kinichi. Study of subcellular distribution of /sup 169/Yb and /sup 111/In in tumor and liver. Japan.
Ando, A, Takeshita, M, Hiraki, T, Ando, Itsuko, and Hisada, Kinichi. 1977. "Study of subcellular distribution of /sup 169/Yb and /sup 111/In in tumor and liver." Japan.
@misc{etde_5087330,
title = {Study of subcellular distribution of /sup 169/Yb and /sup 111/In in tumor and liver}
author = {Ando, A, Takeshita, M, Hiraki, T, Ando, Itsuko, and Hisada, Kinichi}
abstractNote = {Rats were implanted with Yoshida sarcoma and hepatoma AH109A; and mice were implanted with Ehrlich tumor. /sup 169/Yb-citrate and /sup 111/In-citrate were injected into the rats intravenously and into the mice intraperitoneally. Ten minutes to 48 hours after the administration of /sup 169/Yb-citrate and /sup 111/In-citrate, the animals were sacrificed and the tumor tissues and liver were excised. Subcellular fractionation of tumor tissues and liver was carried out according to the method of Hogeboom and Schneider. The /sup 169/Yb and /sup 111/In of each fraction were counted by a well type scintillation counter, and the protein of each fraction was measured according to Lowry's method. In Yoshida sarcoma and Ehrlich tumor, most of the radioactivity was localized in the supernatant fraction, and a small amount of radioactivity was accumulated in the mitochondrial fraction (lysosome is contained in this fraction). But, in the liver, most of the radioactivity was concentrated in the mitochondrial fraction, and the radioactivity of this fraction was increased with the passage of time after administration. Twenty-four hours later, about 50% of the total radioactivity was accumulated in this fraction. In the case of hepatoma AH109A, radioactivity of the mitochondrial fraction was increased with time after administration, and about 30% of total radioactivity was concentrated in this fraction 24 hours after administration. From these results it is concluded that the lysosome does not play an important role in the concentration of /sup 169/Yb and /sup 111/In in the tumor, and that the lysosome plays an important role in the concentration of /sup 169/Yb and /sup 111/In in the liver. In the case of hepatoma AH109A it is presumed that the lysosome plays a very important role in the concentration of /sup 169/Yb and /sup 111/In, in the tumor as hepatoma AH109A retains some nature of liver.}
journal = {Radioisotopes (Tokyo); (Japan)}
volume = {26:3}
journal type = {AC}
place = {Japan}
year = {1977}
month = {Mar}
}