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Osteonecrosis due to radiation given for uterus cervical cancer

Abstract

During a period 1984-1991, 18 patients were diagnosed as developing osteonecrosis after radiation therapy for uterine cervical cancer. The patients had Stage I-III. Acute pain occurred in the lumbar spine, pelvis, and/or limbs. There was no correlation between osteonecrosis and either clinical staging or the associated surgery. The most common site of osteonecrosis was lumbar spine (n=13), followed by sacroiliacal joint and head and neck of femur (5 each) and pubic bone (3). The duration from radiation therapy to occurrence of osteonecrosis varied from one to 8 years: the latency period tended to be longer for younger patients. There was correlation between radiation doses and site of osteonecrosis: 60 Gy caused more extensive osteonecrosis, involving the pelvis and head of femur, although 40 Gy confined it to the lumbo-sacral region. Osteonecrosis was sometimes difficult to diagnose: needle biopsy, in addition to imaging modalities, was necessary in 4 patients. It is recommended that patients with uterus cervical cancer treated with radiation be followed up carefully. (N.K.).
Authors:
Morimoto, Kazuo; Ugai, Kazuhiro; Hasegawa, Kazuo; Hirota, Saeko [1] 
  1. Hyogo Medical Center for Adults, Akashi (Japan)
Publication Date:
Apr 01, 1992
Product Type:
Journal Article
Reference Number:
JPN-92-006498; EDB-92-120051
Resource Relation:
Journal Name: Nippon Gan Chiryo Gakkai-Shi (Journal of Japan Society for Cancer Theory); (Japan); Journal Volume: 27:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PELVIS; OSTEORADIONECROSIS; CARCINOMAS; DELAYED RADIATION EFFECTS; METASTASES; PATIENTS; RADIOTHERAPY; UROGENITAL SYSTEM DISEASES; UTERUS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; BODY AREAS; DISEASES; FEMALE GENITALS; INJURIES; LOCAL RADIATION EFFECTS; MEDICINE; NECROSIS; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATION INJURIES; RADIOLOGY; SKELETAL DISEASES; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5086655
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0021-4671; CODEN: NGCJA
Submitting Site:
JPN
Size:
Pages: 819-826
Announcement Date:
Aug 15, 1992

Citation Formats

Morimoto, Kazuo, Ugai, Kazuhiro, Hasegawa, Kazuo, and Hirota, Saeko. Osteonecrosis due to radiation given for uterus cervical cancer. Japan: N. p., 1992. Web.
Morimoto, Kazuo, Ugai, Kazuhiro, Hasegawa, Kazuo, & Hirota, Saeko. Osteonecrosis due to radiation given for uterus cervical cancer. Japan.
Morimoto, Kazuo, Ugai, Kazuhiro, Hasegawa, Kazuo, and Hirota, Saeko. 1992. "Osteonecrosis due to radiation given for uterus cervical cancer." Japan.
@misc{etde_5086655,
title = {Osteonecrosis due to radiation given for uterus cervical cancer}
author = {Morimoto, Kazuo, Ugai, Kazuhiro, Hasegawa, Kazuo, and Hirota, Saeko}
abstractNote = {During a period 1984-1991, 18 patients were diagnosed as developing osteonecrosis after radiation therapy for uterine cervical cancer. The patients had Stage I-III. Acute pain occurred in the lumbar spine, pelvis, and/or limbs. There was no correlation between osteonecrosis and either clinical staging or the associated surgery. The most common site of osteonecrosis was lumbar spine (n=13), followed by sacroiliacal joint and head and neck of femur (5 each) and pubic bone (3). The duration from radiation therapy to occurrence of osteonecrosis varied from one to 8 years: the latency period tended to be longer for younger patients. There was correlation between radiation doses and site of osteonecrosis: 60 Gy caused more extensive osteonecrosis, involving the pelvis and head of femur, although 40 Gy confined it to the lumbo-sacral region. Osteonecrosis was sometimes difficult to diagnose: needle biopsy, in addition to imaging modalities, was necessary in 4 patients. It is recommended that patients with uterus cervical cancer treated with radiation be followed up carefully. (N.K.).}
journal = []
volume = {27:4}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Apr}
}