You need JavaScript to view this

Monoamine re-uptake sites in the human brain evaluated in vivo by means of /sup 11/C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease

Abstract

Six patients with Parkinson's disease, selected to cover a range of clinical features, and 7 healthy volunteers aged 24-81 years, were examined by positron emission tomography after i.v. injection of racemic /sup 11/C-nomifensine, a catecholamine re-uptake blocking drug. After injection the radiotracer, radioactivity was rapidly distributed to the brain. The highest accumulation of radioactivity was found in areas rich in dopamineric and noradrenergic innervation, such as the striatum and the thalamus. In regions with negible dopaminergic and noradrenergic innervation, such as the cerebellum, radioactivity was lower and evenly distributed. In all investigated brain regions a marked age-related decline in /sup 11/C-nomifensinederived radioactivity relative to the cerebellum was observed in the group of healthy volunteers. Parkinsonian patients did not show such a decline with age. In the group of parkinsonian patients with mainly unilateral involvement, the contralateral putamen exhibited the most pronounced decrease. Only the 3 parkinsonian patients aged 63 and younger showed markedly lower /sup 11/C-nomifensine binding in striatal areas than age-matched healthy volunteers. /sup 11/C-nomifensine seems to be a valuable tool for investigating noradrenergic and dopaminergic re-uptake sites in vivo. Further achievements will most likely be made when the active enantioimer becomes available.
Publication Date:
Jan 01, 1988
Product Type:
Journal Article
Reference Number:
NORN-88-000080; EDB-88-107164
Resource Relation:
Journal Name: Acta Neurol. Scand.; (Denmark); Journal Volume: 77
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CENTRAL NERVOUS SYSTEM AGENTS; CARBON 11; NERVOUS SYSTEM DISEASES; POSITRON COMPUTED TOMOGRAPHY; AGE DEPENDENCE; BRAIN; IN VIVO; PATIENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; RADIOISOTOPES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5084935
Research Organizations:
Departments of Neurology, University Hospital, Uppsala University (SE); Department of Hospital Pharmacy, University Hospital, Uppsala University (SE); The Svedberg Laboratory, Uppsala University (SE); Department of Chemistry, Uppsala University (SE)
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ANRSA
Submitting Site:
DKN
Size:
Pages: 192-201
Announcement Date:
Jun 01, 1988

Citation Formats

Tedroff, J, Aquilonius, S -M, Hartvig, P, Lundqvist, H, Gee, A G, Uhlin, J, and Laangstroem, B. Monoamine re-uptake sites in the human brain evaluated in vivo by means of /sup 11/C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease. Denmark: N. p., 1988. Web.
Tedroff, J, Aquilonius, S -M, Hartvig, P, Lundqvist, H, Gee, A G, Uhlin, J, & Laangstroem, B. Monoamine re-uptake sites in the human brain evaluated in vivo by means of /sup 11/C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease. Denmark.
Tedroff, J, Aquilonius, S -M, Hartvig, P, Lundqvist, H, Gee, A G, Uhlin, J, and Laangstroem, B. 1988. "Monoamine re-uptake sites in the human brain evaluated in vivo by means of /sup 11/C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease." Denmark.
@misc{etde_5084935,
title = {Monoamine re-uptake sites in the human brain evaluated in vivo by means of /sup 11/C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease}
author = {Tedroff, J, Aquilonius, S -M, Hartvig, P, Lundqvist, H, Gee, A G, Uhlin, J, and Laangstroem, B}
abstractNote = {Six patients with Parkinson's disease, selected to cover a range of clinical features, and 7 healthy volunteers aged 24-81 years, were examined by positron emission tomography after i.v. injection of racemic /sup 11/C-nomifensine, a catecholamine re-uptake blocking drug. After injection the radiotracer, radioactivity was rapidly distributed to the brain. The highest accumulation of radioactivity was found in areas rich in dopamineric and noradrenergic innervation, such as the striatum and the thalamus. In regions with negible dopaminergic and noradrenergic innervation, such as the cerebellum, radioactivity was lower and evenly distributed. In all investigated brain regions a marked age-related decline in /sup 11/C-nomifensinederived radioactivity relative to the cerebellum was observed in the group of healthy volunteers. Parkinsonian patients did not show such a decline with age. In the group of parkinsonian patients with mainly unilateral involvement, the contralateral putamen exhibited the most pronounced decrease. Only the 3 parkinsonian patients aged 63 and younger showed markedly lower /sup 11/C-nomifensine binding in striatal areas than age-matched healthy volunteers. /sup 11/C-nomifensine seems to be a valuable tool for investigating noradrenergic and dopaminergic re-uptake sites in vivo. Further achievements will most likely be made when the active enantioimer becomes available.}
journal = []
volume = {77}
journal type = {AC}
place = {Denmark}
year = {1988}
month = {Jan}
}