Abstract
Young baboons (Papio cynocephalus) were vaccinated with ..gamma..-irradiated (500 Gy) cryopreserved Puerto Rican strain schistosomula of S. mansoni. Protection against heterologous, normal Kenyan Strain S. mansoni challenge infection was erratic and partial; and two putative correlates of immunity, reduced worm fecundity and change in worm location (anterior shift) were not observed. However, immunization of baboons with this vaccine resulted in a stimulated immune system. Both cellular and humoral anamnesis were demonstrable in vaccinated-challenged baboons. Schistosome infection-associated IgM hypergammaglobulinemia was also greatly reduced in vaccinated-challenged baboons. However IgG antibodies to adult, egg, and cercarial antigens were increased after challenge infection in preimmunized baboons. Vaccination appears to have resulted in a redirection of the immune system into anti-parasite channels, but this more specific immune response was insufficient to confer good protection against challenge infection in this experiment. The dampening effect of the vaccine on the hypergammaglobulinemia of schistosomiasis is another candidate for a possible ''anti-pathogenesis'' effect of irradiated schistosome larval vaccines.
Damian, R T;
Powell, M R;
Roberts, M L;
[1]
Clark, J D;
[2]
Stirewalt, M A;
Lewis, F A
[3]
- Georgia Univ., Athens (USA). Dept. of Zoology
- Georgia Univ., Athens (USA). Lab. Animal Medicine
- Biomedical Research Inst., Rockville, MD (USA)
Citation Formats
Damian, R T, Powell, M R, Roberts, M L, Clark, J D, Stirewalt, M A, and Lewis, F A.
Schistosoma mansoni: parasitology and immunology of baboons vaccinated with irradiated cryopreserved schistosomula.
United Kingdom: N. p.,
1985.
Web.
doi:10.1016/0020-7519(85)90072-4.
Damian, R T, Powell, M R, Roberts, M L, Clark, J D, Stirewalt, M A, & Lewis, F A.
Schistosoma mansoni: parasitology and immunology of baboons vaccinated with irradiated cryopreserved schistosomula.
United Kingdom.
https://doi.org/10.1016/0020-7519(85)90072-4
Damian, R T, Powell, M R, Roberts, M L, Clark, J D, Stirewalt, M A, and Lewis, F A.
1985.
"Schistosoma mansoni: parasitology and immunology of baboons vaccinated with irradiated cryopreserved schistosomula."
United Kingdom.
https://doi.org/10.1016/0020-7519(85)90072-4.
@misc{etde_5075813,
title = {Schistosoma mansoni: parasitology and immunology of baboons vaccinated with irradiated cryopreserved schistosomula}
author = {Damian, R T, Powell, M R, Roberts, M L, Clark, J D, Stirewalt, M A, and Lewis, F A}
abstractNote = {Young baboons (Papio cynocephalus) were vaccinated with ..gamma..-irradiated (500 Gy) cryopreserved Puerto Rican strain schistosomula of S. mansoni. Protection against heterologous, normal Kenyan Strain S. mansoni challenge infection was erratic and partial; and two putative correlates of immunity, reduced worm fecundity and change in worm location (anterior shift) were not observed. However, immunization of baboons with this vaccine resulted in a stimulated immune system. Both cellular and humoral anamnesis were demonstrable in vaccinated-challenged baboons. Schistosome infection-associated IgM hypergammaglobulinemia was also greatly reduced in vaccinated-challenged baboons. However IgG antibodies to adult, egg, and cercarial antigens were increased after challenge infection in preimmunized baboons. Vaccination appears to have resulted in a redirection of the immune system into anti-parasite channels, but this more specific immune response was insufficient to confer good protection against challenge infection in this experiment. The dampening effect of the vaccine on the hypergammaglobulinemia of schistosomiasis is another candidate for a possible ''anti-pathogenesis'' effect of irradiated schistosome larval vaccines.}
doi = {10.1016/0020-7519(85)90072-4}
journal = []
volume = {15:3}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jun}
}
title = {Schistosoma mansoni: parasitology and immunology of baboons vaccinated with irradiated cryopreserved schistosomula}
author = {Damian, R T, Powell, M R, Roberts, M L, Clark, J D, Stirewalt, M A, and Lewis, F A}
abstractNote = {Young baboons (Papio cynocephalus) were vaccinated with ..gamma..-irradiated (500 Gy) cryopreserved Puerto Rican strain schistosomula of S. mansoni. Protection against heterologous, normal Kenyan Strain S. mansoni challenge infection was erratic and partial; and two putative correlates of immunity, reduced worm fecundity and change in worm location (anterior shift) were not observed. However, immunization of baboons with this vaccine resulted in a stimulated immune system. Both cellular and humoral anamnesis were demonstrable in vaccinated-challenged baboons. Schistosome infection-associated IgM hypergammaglobulinemia was also greatly reduced in vaccinated-challenged baboons. However IgG antibodies to adult, egg, and cercarial antigens were increased after challenge infection in preimmunized baboons. Vaccination appears to have resulted in a redirection of the immune system into anti-parasite channels, but this more specific immune response was insufficient to confer good protection against challenge infection in this experiment. The dampening effect of the vaccine on the hypergammaglobulinemia of schistosomiasis is another candidate for a possible ''anti-pathogenesis'' effect of irradiated schistosome larval vaccines.}
doi = {10.1016/0020-7519(85)90072-4}
journal = []
volume = {15:3}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jun}
}