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Cytogenetic studies on recipients of allogeneic bone marrow transplants after fractionated total body irradiation

Abstract

Cytogenetic findings from the bone marrow (BM) and the peripheral blood (PB) of nine consecutive patients after allogeneic bone marrow transplantation (BMT) for acute or chronic myelogenous leukaemia are reported. After a conditioning regimen consisting of cyclophosphamide and fractionated total body irradiation (TBI) given in five or six fractions of 2 Gy, persistence of host cells was detected in four out of seven cases with permanent engraftment. While one of these patients relapsed 4 months after host cells had been found in BM and PB, the other patients stayed relapse-free 124, 257 and 347 d after grafting. Before transplantation, the leukaemic cells in all three cases carried unique cytogenetic abnormalities giving the opportunity to distinguish the leukaemic population from chromosomally non-aberrant cells thought to represent residual normal host cells. As the persisting host cells after BMT lacked any cytogenetic abnormalities, it is suggested that they were members of residual normal clones not involved in the leukaemic process.
Authors:
Schmitz, N; Goedde-Salz, E; Loeffler, H [1] 
  1. Christian-Albrechts-Univ., Kiel (Germany, F.R.)
Publication Date:
Jun 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-16-077500; EDB-85-186217
Resource Relation:
Journal Name: Br. J. Haematol.; (United Kingdom); Journal Volume: 60:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW CELLS; TRANSPLANTS; CHROMOSOMES; ENDOXAN; FRACTIONATED IRRADIATION; MYELOID LEUKEMIA; PATIENTS; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANIMAL CELLS; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; EXTERNAL IRRADIATION; HEMIC DISEASES; IMMUNOSUPPRESSIVE DRUGS; IRRADIATION; LEUKEMIA; NEOPLASMS; SOMATIC CELLS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5075692
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJHEA
Submitting Site:
HEDB
Size:
Pages: 239-244
Announcement Date:

Citation Formats

Schmitz, N, Goedde-Salz, E, and Loeffler, H. Cytogenetic studies on recipients of allogeneic bone marrow transplants after fractionated total body irradiation. United Kingdom: N. p., 1985. Web. doi:10.1111/j.1365-2141.1985.tb07409.x.
Schmitz, N, Goedde-Salz, E, & Loeffler, H. Cytogenetic studies on recipients of allogeneic bone marrow transplants after fractionated total body irradiation. United Kingdom. doi:10.1111/j.1365-2141.1985.tb07409.x.
Schmitz, N, Goedde-Salz, E, and Loeffler, H. 1985. "Cytogenetic studies on recipients of allogeneic bone marrow transplants after fractionated total body irradiation." United Kingdom. doi:10.1111/j.1365-2141.1985.tb07409.x. https://www.osti.gov/servlets/purl/10.1111/j.1365-2141.1985.tb07409.x.
@misc{etde_5075692,
title = {Cytogenetic studies on recipients of allogeneic bone marrow transplants after fractionated total body irradiation}
author = {Schmitz, N, Goedde-Salz, E, and Loeffler, H}
abstractNote = {Cytogenetic findings from the bone marrow (BM) and the peripheral blood (PB) of nine consecutive patients after allogeneic bone marrow transplantation (BMT) for acute or chronic myelogenous leukaemia are reported. After a conditioning regimen consisting of cyclophosphamide and fractionated total body irradiation (TBI) given in five or six fractions of 2 Gy, persistence of host cells was detected in four out of seven cases with permanent engraftment. While one of these patients relapsed 4 months after host cells had been found in BM and PB, the other patients stayed relapse-free 124, 257 and 347 d after grafting. Before transplantation, the leukaemic cells in all three cases carried unique cytogenetic abnormalities giving the opportunity to distinguish the leukaemic population from chromosomally non-aberrant cells thought to represent residual normal host cells. As the persisting host cells after BMT lacked any cytogenetic abnormalities, it is suggested that they were members of residual normal clones not involved in the leukaemic process.}
doi = {10.1111/j.1365-2141.1985.tb07409.x}
journal = {Br. J. Haematol.; (United Kingdom)}
volume = {60:2}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jun}
}