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Comparison of the effect of interferon on two human hepatoma cell lines

Journal Article:

Abstract

Two human hepatoma cell lines, the PLC/PRF/5 and the Mahlavu cells, which differ in their production of the hepatitis B surface antigen (HBsAg), responded differently to interferon (IFN). After IFN treatment both cell lines were able to inhibit Sindbis virus replication. Oligo A synthetase (E enzyme) could be activated in the PLC/PRF/5 cells although they were not sensitive to exogenous 2 - 5 oligoadenylic acid (2 - 5 A). In contrast, the Mahlavu cells were sensitive to exogenous 2 - 5 A, but unable to activate the E enzyme. Both cell lines were unable to stimulate phosphorylation of the exogenous initiator factor eIF-2.
Authors:
Crespi, M; Schoub, B D; Lyons, S F; Chiu, M N [1] 
  1. University of the Witwatersrand, Johannesburg (South Africa). Dept. of Virology
Publication Date:
Jun 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-16-074624; EDB-85-186475
Resource Relation:
Journal Name: S.Afr. J. Sci.; (South Africa); Journal Volume: 81:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; INTERFERON; BIOLOGICAL EFFECTS; TUMOR CELLS; ENZYME ACTIVITY; ANTIGENS; CALCIUM CHLORIDES; ENZYMES; EXPERIMENTAL DATA; HEPATITIS; HEPATOMAS; LABELLING; PHOSPHORUS 32; PHOSPHORYLATION; RNA; TRACER TECHNIQUES; TRITIUM; ALKALINE EARTH METAL COMPOUNDS; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CALCIUM COMPOUNDS; CALCIUM HALIDES; CHEMICAL REACTIONS; CHLORIDES; CHLORINE COMPOUNDS; DATA; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM DISEASES; DISEASES; HALIDES; HALOGEN COMPOUNDS; HYDROGEN ISOTOPES; INFORMATION; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NEOPLASMS; NUCLEI; NUCLEIC ACIDS; NUMERICAL DATA; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PHOSPHORUS ISOTOPES; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques
OSTI ID:
5074365
Country of Origin:
South Africa
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: SAJSA
Submitting Site:
HEDB
Size:
Pages: 309-312
Announcement Date:

Journal Article:

Citation Formats

Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N. Comparison of the effect of interferon on two human hepatoma cell lines. South Africa: N. p., 1985. Web.
Crespi, M, Schoub, B D, Lyons, S F, & Chiu, M N. Comparison of the effect of interferon on two human hepatoma cell lines. South Africa.
Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N. 1985. "Comparison of the effect of interferon on two human hepatoma cell lines." South Africa.
@misc{etde_5074365,
title = {Comparison of the effect of interferon on two human hepatoma cell lines}
author = {Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N}
abstractNote = {Two human hepatoma cell lines, the PLC/PRF/5 and the Mahlavu cells, which differ in their production of the hepatitis B surface antigen (HBsAg), responded differently to interferon (IFN). After IFN treatment both cell lines were able to inhibit Sindbis virus replication. Oligo A synthetase (E enzyme) could be activated in the PLC/PRF/5 cells although they were not sensitive to exogenous 2 - 5 oligoadenylic acid (2 - 5 A). In contrast, the Mahlavu cells were sensitive to exogenous 2 - 5 A, but unable to activate the E enzyme. Both cell lines were unable to stimulate phosphorylation of the exogenous initiator factor eIF-2.}
journal = {S.Afr. J. Sci.; (South Africa)}
volume = {81:6}
journal type = {AC}
place = {South Africa}
year = {1985}
month = {Jun}
}