Abstract
Two human hepatoma cell lines, the PLC/PRF/5 and the Mahlavu cells, which differ in their production of the hepatitis B surface antigen (HBsAg), responded differently to interferon (IFN). After IFN treatment both cell lines were able to inhibit Sindbis virus replication. Oligo A synthetase (E enzyme) could be activated in the PLC/PRF/5 cells although they were not sensitive to exogenous 2 - 5 oligoadenylic acid (2 - 5 A). In contrast, the Mahlavu cells were sensitive to exogenous 2 - 5 A, but unable to activate the E enzyme. Both cell lines were unable to stimulate phosphorylation of the exogenous initiator factor eIF-2.
Crespi, M;
Schoub, B D;
Lyons, S F;
Chiu, M N
[1]
- University of the Witwatersrand, Johannesburg (South Africa). Dept. of Virology
Citation Formats
Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N.
Comparison of the effect of interferon on two human hepatoma cell lines.
South Africa: N. p.,
1985.
Web.
Crespi, M, Schoub, B D, Lyons, S F, & Chiu, M N.
Comparison of the effect of interferon on two human hepatoma cell lines.
South Africa.
Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N.
1985.
"Comparison of the effect of interferon on two human hepatoma cell lines."
South Africa.
@misc{etde_5074365,
title = {Comparison of the effect of interferon on two human hepatoma cell lines}
author = {Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N}
abstractNote = {Two human hepatoma cell lines, the PLC/PRF/5 and the Mahlavu cells, which differ in their production of the hepatitis B surface antigen (HBsAg), responded differently to interferon (IFN). After IFN treatment both cell lines were able to inhibit Sindbis virus replication. Oligo A synthetase (E enzyme) could be activated in the PLC/PRF/5 cells although they were not sensitive to exogenous 2 - 5 oligoadenylic acid (2 - 5 A). In contrast, the Mahlavu cells were sensitive to exogenous 2 - 5 A, but unable to activate the E enzyme. Both cell lines were unable to stimulate phosphorylation of the exogenous initiator factor eIF-2.}
journal = []
volume = {81:6}
journal type = {AC}
place = {South Africa}
year = {1985}
month = {Jun}
}
title = {Comparison of the effect of interferon on two human hepatoma cell lines}
author = {Crespi, M, Schoub, B D, Lyons, S F, and Chiu, M N}
abstractNote = {Two human hepatoma cell lines, the PLC/PRF/5 and the Mahlavu cells, which differ in their production of the hepatitis B surface antigen (HBsAg), responded differently to interferon (IFN). After IFN treatment both cell lines were able to inhibit Sindbis virus replication. Oligo A synthetase (E enzyme) could be activated in the PLC/PRF/5 cells although they were not sensitive to exogenous 2 - 5 oligoadenylic acid (2 - 5 A). In contrast, the Mahlavu cells were sensitive to exogenous 2 - 5 A, but unable to activate the E enzyme. Both cell lines were unable to stimulate phosphorylation of the exogenous initiator factor eIF-2.}
journal = []
volume = {81:6}
journal type = {AC}
place = {South Africa}
year = {1985}
month = {Jun}
}