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Low toxicity, absorption, turnover and excretion of copper in the Merino sheep

Journal Article:

Abstract

The absorption, storage and excretion of copper has been investigated in Merino sheep following intra-abomasal, intraruminal and intravenous administration of Cu-64. The excretion of the element via bile or urine is strictly limited. There is a most effective mechanism operating in the sheep which limits the intestinal absorption of the element when given in physiological or reasonable pharmacological doses. The absorption is increased to a certain threshold value in animals depleted of copper. In such animals administration of single abnormally large doses of copper does not force more copper through the intestinal mucosa. The ovine sheep liver clears administered copper rapidly from the blood stream and retains it avidly. Excess copper presumably previously loosely bound to albumin is rapidly eliminated by the kidneys. 35 references.
Publication Date:
Jan 01, 1968
Product Type:
Journal Article
Reference Number:
EDB-85-186503
Resource Relation:
Journal Name: J. S.Afr. Vet. Assoc.; (South Africa); Journal Volume: 39:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; COPPER; BIOLOGICAL EFFECTS; SHEEP; BIOLOGICAL ACCUMULATION; DISEASES; INJURIES; BILE; BLOOD; BRAIN; COPPER 64; EXPERIMENTAL DATA; FECES; HEART; INTESTINAL ABSORPTION; KIDNEYS; LIVER; LUNGS; SOUTH AFRICA; SPLEEN; TRACER TECHNIQUES; URINE; ABSORPTION; AFRICA; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COPPER ISOTOPES; DATA; DIGESTIVE SYSTEM; DOMESTIC ANIMALS; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; GLANDS; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; METALS; NERVOUS SYSTEM; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RESPIRATORY SYSTEM; RUMINANTS; TRANSITION ELEMENTS; UPTAKE; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5074196
Research Organizations:
Univ. of Pretoria, South Africa
Country of Origin:
South Africa
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JAVTA
Submitting Site:
HEDB
Size:
Pages: 13-19
Announcement Date:

Journal Article:

Citation Formats

Neethling, L P, Brown, J M.M., and de Wet, P J. Low toxicity, absorption, turnover and excretion of copper in the Merino sheep. South Africa: N. p., 1968. Web.
Neethling, L P, Brown, J M.M., & de Wet, P J. Low toxicity, absorption, turnover and excretion of copper in the Merino sheep. South Africa.
Neethling, L P, Brown, J M.M., and de Wet, P J. 1968. "Low toxicity, absorption, turnover and excretion of copper in the Merino sheep." South Africa.
@misc{etde_5074196,
title = {Low toxicity, absorption, turnover and excretion of copper in the Merino sheep}
author = {Neethling, L P, Brown, J M.M., and de Wet, P J}
abstractNote = {The absorption, storage and excretion of copper has been investigated in Merino sheep following intra-abomasal, intraruminal and intravenous administration of Cu-64. The excretion of the element via bile or urine is strictly limited. There is a most effective mechanism operating in the sheep which limits the intestinal absorption of the element when given in physiological or reasonable pharmacological doses. The absorption is increased to a certain threshold value in animals depleted of copper. In such animals administration of single abnormally large doses of copper does not force more copper through the intestinal mucosa. The ovine sheep liver clears administered copper rapidly from the blood stream and retains it avidly. Excess copper presumably previously loosely bound to albumin is rapidly eliminated by the kidneys. 35 references.}
journal = {J. S.Afr. Vet. Assoc.; (South Africa)}
volume = {39:2}
journal type = {AC}
place = {South Africa}
year = {1968}
month = {Jan}
}