You need JavaScript to view this

Whole-body irradiation in case of malignant lymphomas of low malignancy

Abstract

27 consecutive patients with malignant lymphomas were submittet to whole-body irradiations with doses of 0.5 to 3 Gy. Among these patients ten had been treated before. There were two complete and 16 partial remissions. The condition of five patients could not be considerably improved. Four patients showed a tumor progression during the time of bone marrow depression. The remission period was 11.5 (3 to 22 +) months. The hematologic side effects were considerable; in ten cases, the whole-body irradiation could not be continued because of a thrombocytopenia or an aplastic syndrome. A remarkable fact was the appearance of symptoms similar to that of lupus erythematodes in two patients. An inefficacy of whole-body irradiation did not exclude a response to subsequent chemotherapy. Our own experiences allow to make the following conclusion: in most of all patients with malignant lymphomas of low malignancy a measurable tumor reduction is achieved by whole-body irradiation. Because of the hematologic side effects a whole-body irradiation should be applied only in cases of malignant lymphomas of low malignancy the slow growth of which is proved by observation and which have not been treated before. The thrombocyte numbers should be above 100 000/..mu..l before therapy. Otherwise, the whole-body  More>>
Publication Date:
Apr 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-82-157974
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 158:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HEMATOPOIETIC SYSTEM; EARLY RADIATION EFFECTS; LYMPHOMAS; WHOLE-BODY IRRADIATION; CHEMOTHERAPY; DIAGNOSIS; DOSE-RESPONSE RELATIONSHIPS; FRACTIONATED IRRADIATION; GAMMA RADIATION; GAMMA SOURCES; HISTOLOGY; PATHOLOGY; PATIENTS; RADIOTHERAPY; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIATION SOURCES; RADIATIONS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man
OSTI ID:
5050574
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
HEDB
Size:
Pages: 195-201
Announcement Date:
Sep 01, 1982

Citation Formats

Labedzki, L, Schmidt, R E, Hartlapp, J H, Illiger, H J, Frommhold, H, and Boldt, I. Whole-body irradiation in case of malignant lymphomas of low malignancy. Germany: N. p., 1982. Web.
Labedzki, L, Schmidt, R E, Hartlapp, J H, Illiger, H J, Frommhold, H, & Boldt, I. Whole-body irradiation in case of malignant lymphomas of low malignancy. Germany.
Labedzki, L, Schmidt, R E, Hartlapp, J H, Illiger, H J, Frommhold, H, and Boldt, I. 1982. "Whole-body irradiation in case of malignant lymphomas of low malignancy." Germany.
@misc{etde_5050574,
title = {Whole-body irradiation in case of malignant lymphomas of low malignancy}
author = {Labedzki, L, Schmidt, R E, Hartlapp, J H, Illiger, H J, Frommhold, H, and Boldt, I}
abstractNote = {27 consecutive patients with malignant lymphomas were submittet to whole-body irradiations with doses of 0.5 to 3 Gy. Among these patients ten had been treated before. There were two complete and 16 partial remissions. The condition of five patients could not be considerably improved. Four patients showed a tumor progression during the time of bone marrow depression. The remission period was 11.5 (3 to 22 +) months. The hematologic side effects were considerable; in ten cases, the whole-body irradiation could not be continued because of a thrombocytopenia or an aplastic syndrome. A remarkable fact was the appearance of symptoms similar to that of lupus erythematodes in two patients. An inefficacy of whole-body irradiation did not exclude a response to subsequent chemotherapy. Our own experiences allow to make the following conclusion: in most of all patients with malignant lymphomas of low malignancy a measurable tumor reduction is achieved by whole-body irradiation. Because of the hematologic side effects a whole-body irradiation should be applied only in cases of malignant lymphomas of low malignancy the slow growth of which is proved by observation and which have not been treated before. The thrombocyte numbers should be above 100 000/..mu..l before therapy. Otherwise, the whole-body irradiation has to be stopped before the intended effective dose is reached because of an inevitably developing thrombocytopenia. A whole-body irradiation in case of a malignant lymphoma of low grade malignancy necessitates strict follow-up examinations conducted at regular intervals for a period of at least six weeks after the irradiation. The whole-body irradiation should never be applied as ultima ratio.}
journal = []
volume = {158:4}
journal type = {AC}
place = {Germany}
year = {1982}
month = {Apr}
}