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Myeloid leukaemia frequency after protracted exposure to ionizing radiation: experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with x-rays

Abstract

The dose-response for leukaemia induction by exposure to ionizing radiation protracted over several weeks was largely independent of dose not only in X-rayed patients with ankylosing spondylitis but also in experimentally ..gamma..-rayed CBA/H mice. In the experiment the induced leukaemia frequency of acute myeloid leukaemia was independent of a several thousand-fold variation in physical dose rate. Any difference in leukaemia induction between brief and protracted exposures must therefore depend on specifically biological consequences of protracted exposures. Experimental analysis is required to provide the guides for inference about risks of low level exposure from observations on relatively heavily irradiated populations.
Authors:
Mole, R H; Major, I R [1] 
  1. Medical Research Council, Harwell (UK). Radiobiological Research Unit
Publication Date:
Jan 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-15-013346; EDB-84-077377
Resource Relation:
Journal Name: Leuk. Res.; (United Kingdom); Journal Volume: 7:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; LEUKEMIA; RADIOINDUCTION; SPONDYLITIS; RADIOTHERAPY; DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; X RADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; ELECTROMAGNETIC RADIATION; HEMIC DISEASES; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RHEUMATIC DISEASES; SKELETAL DISEASES; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5016304
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: LERED
Submitting Site:
HEDB
Size:
Pages: 295-300
Announcement Date:

Citation Formats

Mole, R H, and Major, I R. Myeloid leukaemia frequency after protracted exposure to ionizing radiation: experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with x-rays. United Kingdom: N. p., 1983. Web. doi:10.1016/0145-2126(83)90020-6.
Mole, R H, & Major, I R. Myeloid leukaemia frequency after protracted exposure to ionizing radiation: experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with x-rays. United Kingdom. doi:10.1016/0145-2126(83)90020-6.
Mole, R H, and Major, I R. 1983. "Myeloid leukaemia frequency after protracted exposure to ionizing radiation: experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with x-rays." United Kingdom. doi:10.1016/0145-2126(83)90020-6. https://www.osti.gov/servlets/purl/10.1016/0145-2126(83)90020-6.
@misc{etde_5016304,
title = {Myeloid leukaemia frequency after protracted exposure to ionizing radiation: experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with x-rays}
author = {Mole, R H, and Major, I R}
abstractNote = {The dose-response for leukaemia induction by exposure to ionizing radiation protracted over several weeks was largely independent of dose not only in X-rayed patients with ankylosing spondylitis but also in experimentally ..gamma..-rayed CBA/H mice. In the experiment the induced leukaemia frequency of acute myeloid leukaemia was independent of a several thousand-fold variation in physical dose rate. Any difference in leukaemia induction between brief and protracted exposures must therefore depend on specifically biological consequences of protracted exposures. Experimental analysis is required to provide the guides for inference about risks of low level exposure from observations on relatively heavily irradiated populations.}
doi = {10.1016/0145-2126(83)90020-6}
journal = {Leuk. Res.; (United Kingdom)}
volume = {7:2}
journal type = {AC}
place = {United Kingdom}
year = {1983}
month = {Jan}
}