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Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody

Journal Article:

Abstract

Immunoscintigraphy with a technetium-99m murine monoclonal IgG{sub 1} antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE. (orig.).
Authors:
Munz, D L; Sandrock, D; Emrich, D; [1]  Morguet, A J; Heim, A; Sold, G; Figulla, H R; Kreuzer, H [2] 
  1. Goettingen Univ. (Germany). Abt. fuer Nuklearmedizin
  2. Goettingen Univ. (Germany). Abt. fuer Kardiologie und Pulmonologie
Publication Date:
Dec 01, 1991
Product Type:
Journal Article
Reference Number:
DEN-91-010295; EDB-91-163161
Resource Relation:
Journal Name: European Journal of Nuclear Medicine; (Germany); Journal Volume: 18:12
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; INFECTIOUS DISEASES; INFLAMMATION; RADIOIMMUNOSCINTIGRAPHY; MONOCLONAL ANTIBODIES; RADIOPHARMACEUTICALS; ACCURACY; ANTIGENS; CARCINOEMBRYONIC ANTIGEN; DIAGNOSIS; IMAGES; ISOMERIC NUCLEI; LEUKOCYTES; PATIENTS; TECHNETIUM 99; ULTRASONOGRAPHY; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOIMMUNODETECTION; RADIOISOTOPE SCANNING; RADIOISOTOPES; SCINTISCANNING; SYMPTOMS; TECHNETIUM ISOTOPES; TRACER TECHNIQUES; YEARS LIVING RADIOI; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5013397
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0340-6997; CODEN: EJNMD
Submitting Site:
DEN
Size:
Pages: 977-980
Announcement Date:
Dec 15, 1991

Journal Article:

Citation Formats

Munz, D L, Sandrock, D, Emrich, D, Morguet, A J, Heim, A, Sold, G, Figulla, H R, and Kreuzer, H. Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. Germany: N. p., 1991. Web.
Munz, D L, Sandrock, D, Emrich, D, Morguet, A J, Heim, A, Sold, G, Figulla, H R, & Kreuzer, H. Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. Germany.
Munz, D L, Sandrock, D, Emrich, D, Morguet, A J, Heim, A, Sold, G, Figulla, H R, and Kreuzer, H. 1991. "Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody." Germany.
@misc{etde_5013397,
title = {Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody}
author = {Munz, D L, Sandrock, D, Emrich, D, Morguet, A J, Heim, A, Sold, G, Figulla, H R, and Kreuzer, H}
abstractNote = {Immunoscintigraphy with a technetium-99m murine monoclonal IgG{sub 1} antibody directed against non-specific cross-reacting antigen (NCA-95) and carcinoembryonic antigen was performed with 20 patients with suspected subacute infective endocarditis (SIE) and 6 controls with suspected inflammatory/infectious disease elsewhere in the body. Immunoscintigraphy and echocardiography localised SIE in 11 of 15 patients in whom the disease could be confirmed. In 4 patients with validated SIE, the immunoscan was abnormal, and the echocardiogram was normal. In another 4 patients, the result was exactly the opposite. These findings suggest that the combination of immunoscintigraphy and echocardiography improves diagnostic efficacy in patients with suspected SIE. (orig.).}
journal = {European Journal of Nuclear Medicine; (Germany)}
volume = {18:12}
journal type = {AC}
place = {Germany}
year = {1991}
month = {Dec}
}