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Sixteen adult patients with acute leukemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation

Journal Article:

Abstract

Since 1976, 16 adult patients with acute leukemia have been treated by chemotherapy, total body irradiation (TBI) and allogeneic bone marrow transplantation (BMT) in the medical school hospital and the satellite hospitals of Nagoya University. The first group of 10 patients were given marrow grafts at the time of leukemic relapse and the second group of six patients were given the grafts in the period of remission of their disease. For the first group (ALL/ANLL 2:8, age (median) 33, M/F 8:2), HLA-identical donor cells (25 x 10/sup 7//kg(median)) were infused after the patients were conditioned with NSC D 245382 (ACNU) or daunorubicin, cyclophosphamide (CY) and a single shot of 1000 rad of TBI. For the second group (ALL/ANLL 4:2, age (median) 20, M/F 5:1), HLA-identical donor cells (22 x 10/sup 7//kg(median)) were infused after the patients were conditioned with CY and fractionated (250 rad x 4) TBI. All the patients were isolated in a laminar air flow room (LAF) after gut and skin decontamination. Engraftment of donor cells was confirmed in 15 out of the 16 patients. Febrile periods in LAF and the days required for platelet transfusion were prolonged in the first group. All the patients in the first  More>>
Authors:
Kodera, Yoshihisa; Morishima, Yasuo; Morishita, Yoshihisa [1] 
  1. Nagoya Univ. (Japan). Faculty of Medicine
Publication Date:
Dec 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-16-075038; EDB-85-186036
Resource Relation:
Journal Name: Jpn. J. Clin. Oncol.; (Japan); Journal Volume: 14:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW CELLS; GRAFTS; LEUKEMIA; CHEMOTHERAPY; RADIOTHERAPY; FRACTIONATED IRRADIATION; INFECTIOUS DISEASES; PATIENTS; SURVIVAL TIME; WHOLE-BODY IRRADIATION; ANIMAL CELLS; CONNECTIVE TISSUE CELLS; DISEASES; EXTERNAL IRRADIATION; HEMIC DISEASES; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIOLOGY; SOMATIC CELLS; THERAPY; TRANSPLANTS; 550603* - Medicine- External Radiation in Therapy- (1980-); 550600 - Medicine
OSTI ID:
5013060
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JJCOA
Submitting Site:
HEDB
Size:
Pages: 479-486
Announcement Date:

Journal Article:

Citation Formats

Kodera, Yoshihisa, Morishima, Yasuo, and Morishita, Yoshihisa. Sixteen adult patients with acute leukemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation. Japan: N. p., 1984. Web.
Kodera, Yoshihisa, Morishima, Yasuo, & Morishita, Yoshihisa. Sixteen adult patients with acute leukemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation. Japan.
Kodera, Yoshihisa, Morishima, Yasuo, and Morishita, Yoshihisa. 1984. "Sixteen adult patients with acute leukemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation." Japan.
@misc{etde_5013060,
title = {Sixteen adult patients with acute leukemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation}
author = {Kodera, Yoshihisa, Morishima, Yasuo, and Morishita, Yoshihisa}
abstractNote = {Since 1976, 16 adult patients with acute leukemia have been treated by chemotherapy, total body irradiation (TBI) and allogeneic bone marrow transplantation (BMT) in the medical school hospital and the satellite hospitals of Nagoya University. The first group of 10 patients were given marrow grafts at the time of leukemic relapse and the second group of six patients were given the grafts in the period of remission of their disease. For the first group (ALL/ANLL 2:8, age (median) 33, M/F 8:2), HLA-identical donor cells (25 x 10/sup 7//kg(median)) were infused after the patients were conditioned with NSC D 245382 (ACNU) or daunorubicin, cyclophosphamide (CY) and a single shot of 1000 rad of TBI. For the second group (ALL/ANLL 4:2, age (median) 20, M/F 5:1), HLA-identical donor cells (22 x 10/sup 7//kg(median)) were infused after the patients were conditioned with CY and fractionated (250 rad x 4) TBI. All the patients were isolated in a laminar air flow room (LAF) after gut and skin decontamination. Engraftment of donor cells was confirmed in 15 out of the 16 patients. Febrile periods in LAF and the days required for platelet transfusion were prolonged in the first group. All the patients in the first group died within 12-214 days after BMT because of interstitial pneumonitis (7 patients) or bacterial infection (3 patients). On the other hand, five out of six patients in the second group are alive 84-540 days after BMT. For the surviving patients, the complications of chronic graft versus host disease, viral infections, tuberculosis, hepatitis, hemorrhagic cystitis and recurrence of leukemia are now the problems. It can be stated that the patient's clinical condition at the time of BMT is one of the most essential factors for the success of BMT although the effects of other variables, such as a change in the conditioning regimens or the supportive care, must also be carefully analyzed.}
journal = {Jpn. J. Clin. Oncol.; (Japan)}
volume = {14:1}
journal type = {AC}
place = {Japan}
year = {1984}
month = {Dec}
}