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Contribution to the study of the radioprotective effect of serotonin on brain spontaneous and evoked electrical activities in the adult rabbit following whole-body lethal $gamma$-irradiation

Technical Report:

Abstract

Thesis. Submitted to Paris Univ., (France). A 1 to 12 mg/kg serotonin- creatine-sulfate intravenous injection seems to act only slightly on the chronic implanted rabbit CNS except for an increase in latencies and delays of the fast components of evoked potentials and a generalized decrease in the total energy of the signal occurring 20 to 60 min after the injection. The CNS is given a real protection by a 10 mg/kg serotonin injec, tion 20 min before a 650 R whole-body exposure, the spontaneous or induced electrical activity being slightly disturbed. In the hours following irradiation the total energy increase is less important than in the unprotected animal, and there is no clear variation towards the low frequencies. Serotonin could act on the brain structures and the total energy of the signal through its depressing effect. Its radioprotective effect could act, at least partly, through the CNS. (auth)
Authors:
Publication Date:
Nov 01, 1973
Product Type:
Technical Report
Report Number:
CEA-R-4483
Reference Number:
NSA-29-015985
Resource Relation:
Other Information: Thesis. Submitted to Paris Univ., (France)
Subject:
N48520* -Life Sciences-Radiation Effects on Animals- Vertebrates; BRAIN; ELECTRIC CURRENTS; SEROTONIN; RADIOSENSITIVITY EFFECTS; BIOLOGICAL RADIATION EFFECTS; CENTRAL NERVOUS SYSTEM; GAMMA RADIATION; PHOTON BEAMS; RABBITS; RADIATION PROTECTION; RESPONSE MODIFYING FACTORS
Sponsoring Organizations:
Sponsor not identified
OSTI ID:
4936881
Research Organizations:
CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France)
Country of Origin:
France
Language:
French
Availability:
Dep. NTIS (US Sales Only) $7.25.
Submitting Site:
DTIE
Size:
Pages: 103
Announcement Date:
Jun 30, 1974

Technical Report:

Citation Formats

Fatome, M, and Court, L. Contribution to the study of the radioprotective effect of serotonin on brain spontaneous and evoked electrical activities in the adult rabbit following whole-body lethal $gamma$-irradiation. France: N. p., 1973. Web.
Fatome, M, & Court, L. Contribution to the study of the radioprotective effect of serotonin on brain spontaneous and evoked electrical activities in the adult rabbit following whole-body lethal $gamma$-irradiation. France.
Fatome, M, and Court, L. 1973. "Contribution to the study of the radioprotective effect of serotonin on brain spontaneous and evoked electrical activities in the adult rabbit following whole-body lethal $gamma$-irradiation." France.
@misc{etde_4936881,
title = {Contribution to the study of the radioprotective effect of serotonin on brain spontaneous and evoked electrical activities in the adult rabbit following whole-body lethal $gamma$-irradiation}
author = {Fatome, M, and Court, L}
abstractNote = {Thesis. Submitted to Paris Univ., (France). A 1 to 12 mg/kg serotonin- creatine-sulfate intravenous injection seems to act only slightly on the chronic implanted rabbit CNS except for an increase in latencies and delays of the fast components of evoked potentials and a generalized decrease in the total energy of the signal occurring 20 to 60 min after the injection. The CNS is given a real protection by a 10 mg/kg serotonin injec, tion 20 min before a 650 R whole-body exposure, the spontaneous or induced electrical activity being slightly disturbed. In the hours following irradiation the total energy increase is less important than in the unprotected animal, and there is no clear variation towards the low frequencies. Serotonin could act on the brain structures and the total energy of the signal through its depressing effect. Its radioprotective effect could act, at least partly, through the CNS. (auth)}
place = {France}
year = {1973}
month = {Nov}
}