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Bulky carcinogen-DNA adducts and exposure to environmental and occupational sources of polycyclic aromatic hydrocarbons. Influence of susceptibility genotypes on adduct level

Abstract

PAH exposure, whether it is of occupational or environmental origin, is thought to result in an elevated risk of cancer especially in the lungs. DNA damage is considered an important step in the carcinogenic effect of PAH. Hence, methods that elucidate the steps in the carcinogenic process are important to understand the action of PAH. It may prove useful in the exposure assessment and in combination with classical epidemiological methods give better basis for risk estimation. The objective in this thesis was to evaluate the feasibility of the {sup 32}P-postlabeling method to detect carcinogen-DNA adducts for assessing exposure to DNA damaging compounds in different occupationally and environmentally exposed groups. The studies included groups, that have an elevated cancer risk due to occupational exposure to PAH. Exposure levels were supposed to be relatively low according to reports on occupational and environmental air quality programs. Another aim was to evaluate the influence of polymorphisms in metabolizing enzyme genes on DNA adduct levels. A third objective was to establish some kind of baseline DNA adduct level for individuals with supposed low exposure, and compare it to the more exposed groups. A fourth aim in these studies was to examine if biomarkers of genotoxic  More>>
Authors:
Publication Date:
Dec 31, 1996
Product Type:
Thesis/Dissertation
Report Number:
NEI-DK-2582
Reference Number:
SCA: 560161; 553006; PA: AIX-28:036614; EDB-97:082483; NTS-97:012681; SN: 97001795519
Resource Relation:
Other Information: TH: Thesis (ph.d.).; PBD: 1996
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; POLYCYCLIC AROMATIC HYDROCARBONS; CARCINOGENESIS; BIOLOGICAL EFFECTS; DNA ADDUCTS; ENVIRONMENTAL EXPOSURE; LABELLING; LUNGS; OCCUPATIONAL DISEASES; PHOSPHORUS 32
OSTI ID:
480976
Research Organizations:
Aarhus Univ. (Denmark). Inst. for Miljoe- og Arbejdsmedicin; Aarhus Univ. (Denmark)
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Other: ON: DE97624569; TRN: DK9700050036614
Availability:
INIS; OSTI as DE97624569
Submitting Site:
DKN
Size:
[99] p.
Announcement Date:

Citation Formats

Sabro Nielsen, P. Bulky carcinogen-DNA adducts and exposure to environmental and occupational sources of polycyclic aromatic hydrocarbons. Influence of susceptibility genotypes on adduct level. Denmark: N. p., 1996. Web.
Sabro Nielsen, P. Bulky carcinogen-DNA adducts and exposure to environmental and occupational sources of polycyclic aromatic hydrocarbons. Influence of susceptibility genotypes on adduct level. Denmark.
Sabro Nielsen, P. 1996. "Bulky carcinogen-DNA adducts and exposure to environmental and occupational sources of polycyclic aromatic hydrocarbons. Influence of susceptibility genotypes on adduct level." Denmark.
@misc{etde_480976,
title = {Bulky carcinogen-DNA adducts and exposure to environmental and occupational sources of polycyclic aromatic hydrocarbons. Influence of susceptibility genotypes on adduct level}
author = {Sabro Nielsen, P}
abstractNote = {PAH exposure, whether it is of occupational or environmental origin, is thought to result in an elevated risk of cancer especially in the lungs. DNA damage is considered an important step in the carcinogenic effect of PAH. Hence, methods that elucidate the steps in the carcinogenic process are important to understand the action of PAH. It may prove useful in the exposure assessment and in combination with classical epidemiological methods give better basis for risk estimation. The objective in this thesis was to evaluate the feasibility of the {sup 32}P-postlabeling method to detect carcinogen-DNA adducts for assessing exposure to DNA damaging compounds in different occupationally and environmentally exposed groups. The studies included groups, that have an elevated cancer risk due to occupational exposure to PAH. Exposure levels were supposed to be relatively low according to reports on occupational and environmental air quality programs. Another aim was to evaluate the influence of polymorphisms in metabolizing enzyme genes on DNA adduct levels. A third objective was to establish some kind of baseline DNA adduct level for individuals with supposed low exposure, and compare it to the more exposed groups. A fourth aim in these studies was to examine if biomarkers of genotoxic exposure could be useful in epidemiological studies to identify groups at risk and thereby contribute with better exposure estimates in the study of PAH related cancer risk. (EG).}
place = {Denmark}
year = {1996}
month = {Dec}
}