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In vivo dosimetry of high-dose fractionated irradiation in an experimental set-up with rats

Abstract

The feasibility to irradiate a limited section of a rat abdomen with well-defined edges was assessed. Because of the relative small volume involved, in vivo dosimetry with TLDs was necessary in providing us information about the accuracy of the irradiation method. Three to five days prior to the start of the radiotherapy treatment, two plastic strips - each containing a TLD-dosimeter (Harshaw TLD10 LiF rods, 1 mm dia x 6 mm) sealed in polyethylene tubing, and a lead bean - were implanted in the rat abdomen. The plastic strips made a closed loop around the bowel, through the mesenterium, and were fixed with a single stitch on the inner abdominal wall. One loop was made in the hepatic area; another was made in the lower abdomen, around the rectosigmoid. Conscious animals were irradiated using a purpose-build plexi-holder, with rear legs immobilised to avoid longitudinal movements. The implanted lead beans enabled us to simulate the rat prior to each radiation session. This way, the radiation field could be set up individually for each rat, in such way that the rectosigmoid area received full dose and the hepatic area received no irradiation dose at all. Irradiation was carried out, using 5 MV  More>>
Authors:
Fortan, L; Van Hecke, H; Van Duyse, B; De Neve, W; De Meerleer, B; [1]  Pattyn, P; Van Renthergem, K [2] 
  1. Ghent Rijksuniversiteit (Belgium). Kliniek voor Radiotherapie en Kerngeneeskunde
  2. Ghent University (Belgium). Dept. of Surgery
Publication Date:
Dec 01, 1995
Product Type:
Conference
Report Number:
INIS-BE-0001; CONF-951246-
Reference Number:
SCA: 550603; PA: AIX-28:034234; EDB-97:069789; SN: 97001775003
Resource Relation:
Conference: 11. annual symposium of the Belgian Association of Hospital Physicists: conformal radiotherapy - physics, treatment planning and verification, Ghent (Belgium), 8-9 Dec 1995; Other Information: PBD: Dec 1995; Related Information: Is Part Of Conformal Radiotherapy: Physics, Treatment Planning and Verification. Proceedings book; De Wagter, C. [ed.]; PB: 273 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; IRRADIATION DEVICES; DOSIMETRY; RADIOTHERAPY; CONFORMAL MAPPING; BEAM OPTICS; BIOMEDICAL RADIOGRAPHY; COLLIMATORS; DELAYED RADIATION EFFECTS; DOSEMETERS; IMAGE PROCESSING; IMAGE SCANNERS; ISODOSE CURVES; NEOPLASMS; QUALITY ASSURANCE
OSTI ID:
464329
Research Organizations:
Ghent Rijksuniversiteit (Belgium). Kliniek voor Radiotherapie en Kerngeneeskunde
Country of Origin:
Belgium
Language:
English
Other Identifying Numbers:
Other: ON: DE97622340; TRN: BE9700034034234
Availability:
INIS; OSTI as DE97622340
Submitting Site:
BEN
Size:
pp. 17
Announcement Date:

Citation Formats

Fortan, L, Van Hecke, H, Van Duyse, B, De Neve, W, De Meerleer, B, Pattyn, P, and Van Renthergem, K. In vivo dosimetry of high-dose fractionated irradiation in an experimental set-up with rats. Belgium: N. p., 1995. Web.
Fortan, L, Van Hecke, H, Van Duyse, B, De Neve, W, De Meerleer, B, Pattyn, P, & Van Renthergem, K. In vivo dosimetry of high-dose fractionated irradiation in an experimental set-up with rats. Belgium.
Fortan, L, Van Hecke, H, Van Duyse, B, De Neve, W, De Meerleer, B, Pattyn, P, and Van Renthergem, K. 1995. "In vivo dosimetry of high-dose fractionated irradiation in an experimental set-up with rats." Belgium.
@misc{etde_464329,
title = {In vivo dosimetry of high-dose fractionated irradiation in an experimental set-up with rats}
author = {Fortan, L, Van Hecke, H, Van Duyse, B, De Neve, W, De Meerleer, B, Pattyn, P, and Van Renthergem, K}
abstractNote = {The feasibility to irradiate a limited section of a rat abdomen with well-defined edges was assessed. Because of the relative small volume involved, in vivo dosimetry with TLDs was necessary in providing us information about the accuracy of the irradiation method. Three to five days prior to the start of the radiotherapy treatment, two plastic strips - each containing a TLD-dosimeter (Harshaw TLD10 LiF rods, 1 mm dia x 6 mm) sealed in polyethylene tubing, and a lead bean - were implanted in the rat abdomen. The plastic strips made a closed loop around the bowel, through the mesenterium, and were fixed with a single stitch on the inner abdominal wall. One loop was made in the hepatic area; another was made in the lower abdomen, around the rectosigmoid. Conscious animals were irradiated using a purpose-build plexi-holder, with rear legs immobilised to avoid longitudinal movements. The implanted lead beans enabled us to simulate the rat prior to each radiation session. This way, the radiation field could be set up individually for each rat, in such way that the rectosigmoid area received full dose and the hepatic area received no irradiation dose at all. Irradiation was carried out, using 5 MV photons of a linear accelerator. Fifteen animals per group were irradiated according a conventional (2.0 Gy / fraction; 5 fractions / week) or a hyperfractionated (1.6 Gy / fraction; 2 daily fractions; 5 days / week) schedule, with different total doses. Prior to implantation, TLDs were individually calibrated and checked for stability. After removal from the abdomen . TLDs were tested again for accuracy. TLDs with an unacceptable read-out curve were rejected (about 2 to 4 TLDs per group of 15). The obtained accumulated doses - as determined by TLD read-outs-were comparable to the theoretical doses, indicating that fractionated radiation of small fields, with well defined mark off, in rats is feasible.}
place = {Belgium}
year = {1995}
month = {Dec}
}