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Optimization of radiotherapy to target volumes with concave outlines: target-dose homogenization and selective sparing of critical structures by constrained matrix inversion

Abstract

The design of 3D-conformal dose distributions for targets with concave outlines is a technical challenge in conformal radiotherapy. For these targets, it is impossible to find beam incidences for which the target volume can be isolated from the tissues at risk. Commonly occurring examples are most thyroid cancers and the targets located at the lower neck and upper mediastinal levels related to some head and neck. A solution to this problem was developed, using beam intensity modulation executed with a multileaf collimator by applying a static beam-segmentation technique. The method includes the definition of beam incidences and beam segments of specific shape as well as the calculation of segment weights. Tests on Sherouse`s GRATISTM planning system allowed to escalate the dose to these targets to 65-70 Gy without exceeding spinal cord tolerance. Further optimization by constrained matrix inversion was investigated to explore the possibility of further dose escalation.
Publication Date:
Dec 01, 1995
Product Type:
Conference
Report Number:
INIS-BE-0001; CONF-951246-
Reference Number:
SCA: 550603; PA: AIX-28:034213; EDB-97:069775; SN: 97001774981
Resource Relation:
Conference: 11. annual symposium of the Belgian Association of Hospital Physicists: conformal radiotherapy - physics, treatment planning and verification, Ghent (Belgium), 8-9 Dec 1995; Other Information: PBD: Dec 1995; Related Information: Is Part Of Conformal Radiotherapy: Physics, Treatment Planning and Verification. Proceedings book; De Wagter, C. [ed.]; PB: 273 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HEAD; NEOPLASMS; NECK; RADIOTHERAPY; CONFORMAL MAPPING; THYROID; BEAM OPTICS; BIOMEDICAL RADIOGRAPHY; COLLIMATORS; DELAYED RADIATION EFFECTS; DOSIMETRY; IMAGE PROCESSING; IMAGE SCANNERS; ISODOSE CURVES; QUALITY ASSURANCE; TOMOGRAPHY
OSTI ID:
464308
Research Organizations:
Ghent Rijksuniversiteit (Belgium). Kliniek voor Radiotherapie en Kerngeneeskunde
Country of Origin:
Belgium
Language:
English
Other Identifying Numbers:
Other: ON: DE97622340; TRN: BE9700012034213
Availability:
INIS; OSTI as DE97622340
Submitting Site:
BEN
Size:
pp. 87-92
Announcement Date:

Citation Formats

Colle, C, Van den Berge, D, De Wagter, C, Fortan, L, Van Duyse, B, and De Neve, W. Optimization of radiotherapy to target volumes with concave outlines: target-dose homogenization and selective sparing of critical structures by constrained matrix inversion. Belgium: N. p., 1995. Web.
Colle, C, Van den Berge, D, De Wagter, C, Fortan, L, Van Duyse, B, & De Neve, W. Optimization of radiotherapy to target volumes with concave outlines: target-dose homogenization and selective sparing of critical structures by constrained matrix inversion. Belgium.
Colle, C, Van den Berge, D, De Wagter, C, Fortan, L, Van Duyse, B, and De Neve, W. 1995. "Optimization of radiotherapy to target volumes with concave outlines: target-dose homogenization and selective sparing of critical structures by constrained matrix inversion." Belgium.
@misc{etde_464308,
title = {Optimization of radiotherapy to target volumes with concave outlines: target-dose homogenization and selective sparing of critical structures by constrained matrix inversion}
author = {Colle, C, Van den Berge, D, De Wagter, C, Fortan, L, Van Duyse, B, and De Neve, W}
abstractNote = {The design of 3D-conformal dose distributions for targets with concave outlines is a technical challenge in conformal radiotherapy. For these targets, it is impossible to find beam incidences for which the target volume can be isolated from the tissues at risk. Commonly occurring examples are most thyroid cancers and the targets located at the lower neck and upper mediastinal levels related to some head and neck. A solution to this problem was developed, using beam intensity modulation executed with a multileaf collimator by applying a static beam-segmentation technique. The method includes the definition of beam incidences and beam segments of specific shape as well as the calculation of segment weights. Tests on Sherouse`s GRATISTM planning system allowed to escalate the dose to these targets to 65-70 Gy without exceeding spinal cord tolerance. Further optimization by constrained matrix inversion was investigated to explore the possibility of further dose escalation.}
place = {Belgium}
year = {1995}
month = {Dec}
}