The ten-year operational experience of four WWER-440 units in Dukovany NPP with a total number of 35 cycles is outlined. The strategy of fuel reloading has been changed from out-in schemes to low-leakage patterns. The linear pin power limitation will be introduced. The main physical limits and conditions for the NPP operation are listed. The main goal is to go to a full 4-year fuel cycle in which the burnup will be about 40 Mwd/kg U. 6 tabs.