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Pharmacological toxicological studies on certain drugs subjected to radiation or used radioprotective agents

Abstract

The present study represents two main subjects. The first encounters the effect of radiosterilization of certain pharmaceretical preparations such as antihistaminics (cimetidine), anticonvulsants (diazepam), beta and calcium channel blacker (propranolol and verapamil) on their pharmacological activity. Results of this study revealed that the previously mentioned drugs can be effectively and safely sterilized by gamma irradiation without deleterious effect on their pharmacological activity. The other subject presented in this study is essentially a pharmacological subject encountering toxicological problems. Data of this study demonstrated that chemical radiation protection has been successfully reported using single drug administration has been successfully reported using single drug administration such as imidazole, and Sh-bearing compounds. In the present work, the radioprotective effect of imidazole was demonstrated on the cardiovascular and respiratory systems. Furthermore, combined drug administration was found to exert more protective action with less toxicity and therefore minimize the side effects of the radioprotective drugs. Thus, combination of imidazole and serotonin showed potential protective effect on blood gases was also reported. In addition, combination of cysteine and vitamin E afforded a better protection on adrenocortical function in rats than either agent alone. 4 figs., 1 tab.
Authors:
Hassan, S H.M. [1] 
  1. Durng Research Dept., National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, (Egypt)
Publication Date:
Oct 01, 1995
Product Type:
Miscellaneous
Report Number:
INIS-EG-001; CONF-9411323-
Reference Number:
SCA: 553006; PA: AIX-28:030293; EDB-97:057909; SN: 97001765112
Resource Relation:
Conference: 2. Arab conference on the peaceful uses of atomic energy, Cairo (Egypt), 5-9 Nov 1994; Other Information: PBD: Oct 1995; Related Information: Is Part Of Proceedings of the second Arab conference on the peaceful uses of atomic energy. Part II: A and B; Barakat, M.F.; El-Mashri, S.M. [eds.]; PB: 1199 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DRUGS; PHARMACOLOGY; TOXICITY; ANTICONVULSANTS; ANTIHISTAMINICS; EXPERIMENTAL DATA; GAMMA RADIATION; IMIDAZOLES; RADIOPROTECTIVE SUBSTANCES; RADIOSTERILIZATION; RATS; VITAMIN E
OSTI ID:
456005
Research Organizations:
Atomic Energy Authority, Cairo (Egypt); Arab Atomic Energy Agency (AAEA), Tunis (Tunisia); Middle Eastern Regional Radioisotope Centre for the Arab Countries, Cairo (Egypt)
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
Other: ON: DE97620040; ISBN 9973-9927-3-3; TRN: EG9601680030293
Availability:
INIS; OSTI as DE97620040
Submitting Site:
INIS
Size:
pp. 629
Announcement Date:

Citation Formats

Hassan, S H.M. Pharmacological toxicological studies on certain drugs subjected to radiation or used radioprotective agents. Egypt: N. p., 1995. Web.
Hassan, S H.M. Pharmacological toxicological studies on certain drugs subjected to radiation or used radioprotective agents. Egypt.
Hassan, S H.M. 1995. "Pharmacological toxicological studies on certain drugs subjected to radiation or used radioprotective agents." Egypt.
@misc{etde_456005,
title = {Pharmacological toxicological studies on certain drugs subjected to radiation or used radioprotective agents}
author = {Hassan, S H.M.}
abstractNote = {The present study represents two main subjects. The first encounters the effect of radiosterilization of certain pharmaceretical preparations such as antihistaminics (cimetidine), anticonvulsants (diazepam), beta and calcium channel blacker (propranolol and verapamil) on their pharmacological activity. Results of this study revealed that the previously mentioned drugs can be effectively and safely sterilized by gamma irradiation without deleterious effect on their pharmacological activity. The other subject presented in this study is essentially a pharmacological subject encountering toxicological problems. Data of this study demonstrated that chemical radiation protection has been successfully reported using single drug administration has been successfully reported using single drug administration such as imidazole, and Sh-bearing compounds. In the present work, the radioprotective effect of imidazole was demonstrated on the cardiovascular and respiratory systems. Furthermore, combined drug administration was found to exert more protective action with less toxicity and therefore minimize the side effects of the radioprotective drugs. Thus, combination of imidazole and serotonin showed potential protective effect on blood gases was also reported. In addition, combination of cysteine and vitamin E afforded a better protection on adrenocortical function in rats than either agent alone. 4 figs., 1 tab.}
place = {Egypt}
year = {1995}
month = {Oct}
}