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Converting dose distributions into tumour control probability

Abstract

The endpoints in radiotherapy that are truly of relevance are not dose distributions but the probability of local control, sometimes known as the Tumour Control Probability (TCP) and the Probability of Normal Tissue Complications (NTCP). A model for the estimation of TCP based on simple radiobiological considerations is described. It is shown that incorporation of inter-patient heterogeneity into the radiosensitivity parameter a through s{sub a} can result in a clinically realistic slope for the dose-response curve. The model is applied to inhomogeneous target dose distributions in order to demonstrate the relationship between dose uniformity and s{sub a}. The consequences of varying clonogenic density are also explored. Finally the model is applied to the target-volume DVHs for patients in a clinical trial of conformal pelvic radiotherapy; the effect of dose inhomogeneities on distributions of TCP are shown as well as the potential benefits of customizing the target dose according to normal-tissue DVHs. (author). 37 refs, 9 figs.
Authors:
Nahum, A E [1] 
  1. The Royal Marsden Hospital, London (United Kingdom). Joint Dept. of Physics
Publication Date:
Aug 01, 1996
Product Type:
Conference
Report Number:
IAEA-TECDOC-896; CONF-940864-
Reference Number:
SCA: 550603; 560151; 560101; PA: AIX-28:018203; EDB-97:029544; SN: 97001735898
Resource Relation:
Conference: Interregional seminar on radiotherapy dosimetry: radiation dose in radiotherapy from prescription to delivery, Rio de Janeiro (Brazil), 27-30 Aug 1994; Other Information: PBD: Aug 1996; Related Information: Is Part Of Radiation dose in radiotherapy from prescription to delivery; PB: 293 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; ANIMAL TISSUES; DOSE-RESPONSE RELATIONSHIPS; RADIOTHERAPY; BIOLOGICAL MODELS; TUMOR CELLS; FRACTIONATED IRRADIATION; ALPHA PARTICLES; BIOLOGICAL RADIATION EFFECTS; CARCINOMAS; DOSIMETRY; GAMMA RADIATION; PROBABILITY; RADIATION DOSE DISTRIBUTIONS; THREE-DIMENSIONAL CALCULATIONS
OSTI ID:
429940
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1011-4289; Other: ON: DE97614216; TRN: XA9642843018203
Availability:
INIS; OSTI as DE97614216
Submitting Site:
INIS
Size:
pp. 27-40
Announcement Date:

Citation Formats

Nahum, A E. Converting dose distributions into tumour control probability. IAEA: N. p., 1996. Web.
Nahum, A E. Converting dose distributions into tumour control probability. IAEA.
Nahum, A E. 1996. "Converting dose distributions into tumour control probability." IAEA.
@misc{etde_429940,
title = {Converting dose distributions into tumour control probability}
author = {Nahum, A E}
abstractNote = {The endpoints in radiotherapy that are truly of relevance are not dose distributions but the probability of local control, sometimes known as the Tumour Control Probability (TCP) and the Probability of Normal Tissue Complications (NTCP). A model for the estimation of TCP based on simple radiobiological considerations is described. It is shown that incorporation of inter-patient heterogeneity into the radiosensitivity parameter a through s{sub a} can result in a clinically realistic slope for the dose-response curve. The model is applied to inhomogeneous target dose distributions in order to demonstrate the relationship between dose uniformity and s{sub a}. The consequences of varying clonogenic density are also explored. Finally the model is applied to the target-volume DVHs for patients in a clinical trial of conformal pelvic radiotherapy; the effect of dose inhomogeneities on distributions of TCP are shown as well as the potential benefits of customizing the target dose according to normal-tissue DVHs. (author). 37 refs, 9 figs.}
place = {IAEA}
year = {1996}
month = {Aug}
}