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Tumor and normal tissue responses to fractioned non-uniform dose delivery

Abstract

The volume dependence of the radiation response of a tumor is straight forward to quantify because it depends primarily on the eradication of all its clonogenic cells. A tumor therefore has a parallel organization as any surviving clonogen in principle can repopulate the tumor. The difficulty with the response of the tumor is instead to know the density and sensitivity distribution of the most resistant clonogenic cells. The increase in the 50% tumor control dose and the decrease in the maximum normalized slope of the dose response relation, {gamma}, in presence of small compartments of resistant tumor cells have therefore been quantified to describe their influence on the dose response relation. Injury to normal tissue is a much more complex and gradual process. It depends on earlier effects induced long before depletion of the differentiated and clonogenic cells that in addition may have a complex structural and functional organization. The volume dependence of the dose response relation of normal tissues is therefore described here by the relative seriality, s, of the infrastructure of the organ. The model can also be generalized to describe the response of heterogeneous tissues to non uniform dose distributions. The new model is compared with clinical  More>>
Authors:
Kaellman, P; Aegren, A; Brahme, A [1] 
  1. Karolinska Inst., Stockholm (Sweden). Dept. of Radiation Physics
Publication Date:
Aug 01, 1996
Product Type:
Conference
Report Number:
IAEA-TECDOC-896; CONF-940864-
Reference Number:
SCA: 550603; 560151; PA: AIX-28:018202; EDB-97:029541; SN: 97001735897
Resource Relation:
Conference: Interregional seminar on radiotherapy dosimetry: radiation dose in radiotherapy from prescription to delivery, Rio de Janeiro (Brazil), 27-30 Aug 1994; Other Information: PBD: Aug 1996; Related Information: Is Part Of Radiation dose in radiotherapy from prescription to delivery; PB: 293 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; ANIMAL TISSUES; DOSE-RESPONSE RELATIONSHIPS; TUMOR CELLS; FRACTIONATED IRRADIATION; ALPHA PARTICLES; BIOLOGICAL RADIATION EFFECTS; CARCINOMAS; DOSIMETRY; EXTERNAL IRRADIATION; GAMMA RADIATION; RADIATION DOSE DISTRIBUTIONS; RADIATION PROTECTION; RADIOTHERAPY
OSTI ID:
429939
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1011-4289; Other: ON: DE97614216; TRN: XA9642842018202
Availability:
INIS; OSTI as DE97614216
Submitting Site:
INIS
Size:
pp. 9-25
Announcement Date:
Feb 24, 1997

Citation Formats

Kaellman, P, Aegren, A, and Brahme, A. Tumor and normal tissue responses to fractioned non-uniform dose delivery. IAEA: N. p., 1996. Web.
Kaellman, P, Aegren, A, & Brahme, A. Tumor and normal tissue responses to fractioned non-uniform dose delivery. IAEA.
Kaellman, P, Aegren, A, and Brahme, A. 1996. "Tumor and normal tissue responses to fractioned non-uniform dose delivery." IAEA.
@misc{etde_429939,
title = {Tumor and normal tissue responses to fractioned non-uniform dose delivery}
author = {Kaellman, P, Aegren, A, and Brahme, A}
abstractNote = {The volume dependence of the radiation response of a tumor is straight forward to quantify because it depends primarily on the eradication of all its clonogenic cells. A tumor therefore has a parallel organization as any surviving clonogen in principle can repopulate the tumor. The difficulty with the response of the tumor is instead to know the density and sensitivity distribution of the most resistant clonogenic cells. The increase in the 50% tumor control dose and the decrease in the maximum normalized slope of the dose response relation, {gamma}, in presence of small compartments of resistant tumor cells have therefore been quantified to describe their influence on the dose response relation. Injury to normal tissue is a much more complex and gradual process. It depends on earlier effects induced long before depletion of the differentiated and clonogenic cells that in addition may have a complex structural and functional organization. The volume dependence of the dose response relation of normal tissues is therefore described here by the relative seriality, s, of the infrastructure of the organ. The model can also be generalized to describe the response of heterogeneous tissues to non uniform dose distributions. The new model is compared with clinical and experimental data on normal tissue response, and shows good agreement both with regard to the shape of dose response relation and the volume dependence of the isoeffect dose. The response of tumors and normal tissues are quantified for arbitrary dose fractionations using the linear quadratic cell survival parameters {alpha} and {beta}. The parameters of the dose response relation are derived both for a constant dose per fraction and a constant number of dose fractions, thus in the latter case accounting also for non uniform dose delivery. (author). 26 refs, 4 figs.}
place = {IAEA}
year = {1996}
month = {Aug}
}