You need JavaScript to view this

Effect of altitude on the protein metabolism of Bolivian children

Abstract

The malnutrition is prevalent and is a major problem among Bolivian children. It is caused by several interacting factors: (1) inadequate protein energy intake due to low socio-economic status; (ii) exposure to acute, repeated and chronic bacterial infections; (iii) exposure to multiple and chronic parasitic infections; (iv) high altitude of the capital, La Paz, 3600 m, with a numerous populations compared to the rest of the country. The research objectives in the first phase are: (i) determination of protein utilization with a non-invasive method using stable isotope tracer among children living at high and low altitude; (ii) determination of protein metabolism among eutrophic children without parasitic or acute bacterial infections at both altitudes; (iii) determination of protein requirement among these children. Two groups of 10 pubertal children, matched for age and sex, of same socio-economic status, eutrophic, without malnutrition, infections or intestinal parasites will be studied; the different status being arrived by anthropometric, nutritional intake, biochemical and pediatrical evaluation. For the metabolic study, stable isotopes L-[1-13C] leucine labelled casein will be used and {sup 13}CO{sub 2} excreted will be measured. All the basic nutritional assessment and VCO{sub 2} measurements will be performed in Bolivia, while the samples of expired gas  More>>
Authors:
San Miguel Simron, J L; Berger, J; Spielvogel, H; Tellez Castellon, W; Lujan Medina, C; Caceres, E; [1]  Beaufrere, B; Gachons, P; Coudert, J [2] 
  1. Instituto Boliviano de Boliviano de Biologia de Altura, La Paz (Bolivia). Dept. de Nutricion
  2. Laboratoire de Nutrition Humaine, Clermont-Ferrand (France)
Publication Date:
Dec 31, 1996
Product Type:
Conference
Report Number:
NAHRES-30; CONF-9503281-
Reference Number:
SCA: 553006; 553004; PA: AIX-28:013007; EDB-97:029690; SN: 97001730578
Resource Relation:
Conference: 2. research co-ordination meeting on application of stable isotope tracer methods to studies of amino acid, protein, and energy metabolism in malnourished populations of developing countries, Kingston (Jamaica), 21-24 Mar 1995; Other Information: PBD: 1996; Related Information: Is Part Of Co-ordinated research programme on application of stable isotope tracer methods to studies of amino acid, protein, and energy metabolism in malnourished populations of developing countries. Report on the second research co-ordination meeting; PB: 98 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CHILDREN; DISEASE RESISTANCE; NUTRITIONAL DEFICIENCY; NUTRITION; TRACER TECHNIQUES; BACTERIAL DISEASES; BOLIVIA; CARBON DIOXIDE; CARBON 13; FOOD; METABOLISM; PARASITES; PROTEINS; SOCIO-ECONOMIC FACTORS; VEGETABLES
OSTI ID:
424814
Research Organizations:
International Atomic Energy Agency, Vienna (Austria). Section of Nutritional and Health-Related Environmental Studies
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ON: DE97612485; TRN: XA9642961013007
Availability:
INIS; OSTI as DE97612485
Submitting Site:
INIS
Size:
pp. 20-29
Announcement Date:
Feb 14, 1997

Citation Formats

San Miguel Simron, J L, Berger, J, Spielvogel, H, Tellez Castellon, W, Lujan Medina, C, Caceres, E, Beaufrere, B, Gachons, P, and Coudert, J. Effect of altitude on the protein metabolism of Bolivian children. IAEA: N. p., 1996. Web.
San Miguel Simron, J L, Berger, J, Spielvogel, H, Tellez Castellon, W, Lujan Medina, C, Caceres, E, Beaufrere, B, Gachons, P, & Coudert, J. Effect of altitude on the protein metabolism of Bolivian children. IAEA.
San Miguel Simron, J L, Berger, J, Spielvogel, H, Tellez Castellon, W, Lujan Medina, C, Caceres, E, Beaufrere, B, Gachons, P, and Coudert, J. 1996. "Effect of altitude on the protein metabolism of Bolivian children." IAEA.
@misc{etde_424814,
title = {Effect of altitude on the protein metabolism of Bolivian children}
author = {San Miguel Simron, J L, Berger, J, Spielvogel, H, Tellez Castellon, W, Lujan Medina, C, Caceres, E, Beaufrere, B, Gachons, P, and Coudert, J}
abstractNote = {The malnutrition is prevalent and is a major problem among Bolivian children. It is caused by several interacting factors: (1) inadequate protein energy intake due to low socio-economic status; (ii) exposure to acute, repeated and chronic bacterial infections; (iii) exposure to multiple and chronic parasitic infections; (iv) high altitude of the capital, La Paz, 3600 m, with a numerous populations compared to the rest of the country. The research objectives in the first phase are: (i) determination of protein utilization with a non-invasive method using stable isotope tracer among children living at high and low altitude; (ii) determination of protein metabolism among eutrophic children without parasitic or acute bacterial infections at both altitudes; (iii) determination of protein requirement among these children. Two groups of 10 pubertal children, matched for age and sex, of same socio-economic status, eutrophic, without malnutrition, infections or intestinal parasites will be studied; the different status being arrived by anthropometric, nutritional intake, biochemical and pediatrical evaluation. For the metabolic study, stable isotopes L-[1-13C] leucine labelled casein will be used and {sup 13}CO{sub 2} excreted will be measured. All the basic nutritional assessment and VCO{sub 2} measurements will be performed in Bolivia, while the samples of expired gas will be stored in Vacutainers for further analysis by isotope radio mass spectrometer (IRMS), in Clermont-Ferrand, France. The plans for future work is based on the study of the effects of the different variables and their interactions. The following will be evaluated: (i) the socio-economic status; (ii) the bacterial infections: (iii) the parasitic infections; (iv) the altitude. As published by Obert, et al., the socio-economic variable is more connected with the nutritional status than with the altitude. 12 refs, 1 fig., 1 tab.}
place = {IAEA}
year = {1996}
month = {Dec}
}