Abstract
The aim of this project is to investigate the effects of ionizing radiation (<10 Gy) on several parameters of gastrointestinal function: (a) regulatory peptides; (b) pancreatic and biliary secretions and (c) electrolyte and lipid transport using both gamma alone (cobalt-60) and a mixture of gamma/neutron ({gamma}/N Silene reactor) in two animal models, the rat and the pig. Preliminary data in rats following gamma irradiation (2-8 Gy) show that plasma nurotensin gastrin releasing peptide and substance P are increased in a dose dependent manner most markedly between two and four days after exposure. Intestinal brush border marker enzyme activities (sucrose and leucine amino-peptidase) were also reduced. Such differences were more marked and persisted longer after {gamma}/N irradiation (2-4 Gy: +Pb: {gamma}/:N =0.2). Following the latter type of irradiation (4 Gy) plasma cholesterol increased as well as the cholesterol/phospholipid ratio. Analysis of cholesterol distribution in lipoprotein actions revealed a large increase in cholesterol carried b High Density Lipoprotein-1 (HDL1). In the pig following either type of irradiation the volumes of both pancreatic and biliary secretions were reduced. Irradiation of pigs with either {gamma} (6 Gy) alone or {gamma}/N (6 Gy: {gamma}/N I :1) resulted in a marked decrease in both brush border
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Bertin, C;
Dublineau, I;
Griffiths, N M;
Joubert, C;
Linard, C;
Martin, J M;
Mathe, D;
Scanff, P;
Valette, P
[1]
- CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire
Citation Formats
Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P.
Effects of ionizing radiation on gastrointestinal function.
Croatia: N. p.,
1994.
Web.
Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, & Valette, P.
Effects of ionizing radiation on gastrointestinal function.
Croatia.
Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P.
1994.
"Effects of ionizing radiation on gastrointestinal function."
Croatia.
@misc{etde_408388,
title = {Effects of ionizing radiation on gastrointestinal function}
author = {Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P}
abstractNote = {The aim of this project is to investigate the effects of ionizing radiation (<10 Gy) on several parameters of gastrointestinal function: (a) regulatory peptides; (b) pancreatic and biliary secretions and (c) electrolyte and lipid transport using both gamma alone (cobalt-60) and a mixture of gamma/neutron ({gamma}/N Silene reactor) in two animal models, the rat and the pig. Preliminary data in rats following gamma irradiation (2-8 Gy) show that plasma nurotensin gastrin releasing peptide and substance P are increased in a dose dependent manner most markedly between two and four days after exposure. Intestinal brush border marker enzyme activities (sucrose and leucine amino-peptidase) were also reduced. Such differences were more marked and persisted longer after {gamma}/N irradiation (2-4 Gy: +Pb: {gamma}/:N =0.2). Following the latter type of irradiation (4 Gy) plasma cholesterol increased as well as the cholesterol/phospholipid ratio. Analysis of cholesterol distribution in lipoprotein actions revealed a large increase in cholesterol carried b High Density Lipoprotein-1 (HDL1). In the pig following either type of irradiation the volumes of both pancreatic and biliary secretions were reduced. Irradiation of pigs with either {gamma} (6 Gy) alone or {gamma}/N (6 Gy: {gamma}/N I :1) resulted in a marked decrease in both brush border (sucrase: leucine aminopeptidase) and basolateral (sodium ump` aden late cyclase) enzyme activities. Vasoactive intestinal peptide (VIP) stimulated adenylate cyclase was markedly attenuated and in addition specific VIP binding was modified as shown by a reduction in receptor affinity. The significance of the data will be discussed and the importance of a new therapeutic strategies or new biological markers of radiation-induced gastrointestinal dysfunction.}
place = {Croatia}
year = {1994}
month = {Oct}
}
title = {Effects of ionizing radiation on gastrointestinal function}
author = {Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P}
abstractNote = {The aim of this project is to investigate the effects of ionizing radiation (<10 Gy) on several parameters of gastrointestinal function: (a) regulatory peptides; (b) pancreatic and biliary secretions and (c) electrolyte and lipid transport using both gamma alone (cobalt-60) and a mixture of gamma/neutron ({gamma}/N Silene reactor) in two animal models, the rat and the pig. Preliminary data in rats following gamma irradiation (2-8 Gy) show that plasma nurotensin gastrin releasing peptide and substance P are increased in a dose dependent manner most markedly between two and four days after exposure. Intestinal brush border marker enzyme activities (sucrose and leucine amino-peptidase) were also reduced. Such differences were more marked and persisted longer after {gamma}/N irradiation (2-4 Gy: +Pb: {gamma}/:N =0.2). Following the latter type of irradiation (4 Gy) plasma cholesterol increased as well as the cholesterol/phospholipid ratio. Analysis of cholesterol distribution in lipoprotein actions revealed a large increase in cholesterol carried b High Density Lipoprotein-1 (HDL1). In the pig following either type of irradiation the volumes of both pancreatic and biliary secretions were reduced. Irradiation of pigs with either {gamma} (6 Gy) alone or {gamma}/N (6 Gy: {gamma}/N I :1) resulted in a marked decrease in both brush border (sucrase: leucine aminopeptidase) and basolateral (sodium ump` aden late cyclase) enzyme activities. Vasoactive intestinal peptide (VIP) stimulated adenylate cyclase was markedly attenuated and in addition specific VIP binding was modified as shown by a reduction in receptor affinity. The significance of the data will be discussed and the importance of a new therapeutic strategies or new biological markers of radiation-induced gastrointestinal dysfunction.}
place = {Croatia}
year = {1994}
month = {Oct}
}