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Effects of ionizing radiation on gastrointestinal function

Abstract

The aim of this project is to investigate the effects of ionizing radiation (<10 Gy) on several parameters of gastrointestinal function: (a) regulatory peptides; (b) pancreatic and biliary secretions and (c) electrolyte and lipid transport using both gamma alone (cobalt-60) and a mixture of gamma/neutron ({gamma}/N Silene reactor) in two animal models, the rat and the pig. Preliminary data in rats following gamma irradiation (2-8 Gy) show that plasma nurotensin gastrin releasing peptide and substance P are increased in a dose dependent manner most markedly between two and four days after exposure. Intestinal brush border marker enzyme activities (sucrose and leucine amino-peptidase) were also reduced. Such differences were more marked and persisted longer after {gamma}/N irradiation (2-4 Gy: +Pb: {gamma}/:N =0.2). Following the latter type of irradiation (4 Gy) plasma cholesterol increased as well as the cholesterol/phospholipid ratio. Analysis of cholesterol distribution in lipoprotein actions revealed a large increase in cholesterol carried b High Density Lipoprotein-1 (HDL1). In the pig following either type of irradiation the volumes of both pancreatic and biliary secretions were reduced. Irradiation of pigs with either {gamma} (6 Gy) alone or {gamma}/N (6 Gy: {gamma}/N I :1) resulted in a marked decrease in both brush border  More>>
Authors:
Bertin, C; Dublineau, I; Griffiths, N M; Joubert, C; Linard, C; Martin, J M; Mathe, D; Scanff, P; Valette, P [1] 
  1. CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire
Publication Date:
Oct 01, 1994
Product Type:
Conference
Report Number:
INIS-mf-14931; CONF-9410480-
Reference Number:
SCA: 560152; 560162; PA: AIX-28:000653; EDB-97:010312; SN: 97001711238
Resource Relation:
Conference: 1. Croatian international congress of nuclear medicine, Zagreb (Croatia), 13-15 Oct 1994; Other Information: PBD: Oct 1994; Related Information: Is Part Of Abstracts of the 1st croatian international congress of nuclear medicine; PB: 28 p.
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; GASTROINTESTINAL TRACT; IONIZING RADIATIONS; BIOLOGICAL RADIATION EFFECTS; COBALT 60; NEUTRONS; RADIATION DOSES; RATS; SWINE
OSTI ID:
408388
Research Organizations:
Croatian Medical Association, Zagreb (Croatia); Croatian Society of Nuclear Medicine, Zagreb (Croatia)
Country of Origin:
Croatia
Language:
English
Other Identifying Numbers:
Other: ON: DE97605734; TRN: HR9600032000653
Availability:
INIS; OSTI as DE97605734
Submitting Site:
INIS
Size:
pp. 9
Announcement Date:

Citation Formats

Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P. Effects of ionizing radiation on gastrointestinal function. Croatia: N. p., 1994. Web.
Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, & Valette, P. Effects of ionizing radiation on gastrointestinal function. Croatia.
Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P. 1994. "Effects of ionizing radiation on gastrointestinal function." Croatia.
@misc{etde_408388,
title = {Effects of ionizing radiation on gastrointestinal function}
author = {Bertin, C, Dublineau, I, Griffiths, N M, Joubert, C, Linard, C, Martin, J M, Mathe, D, Scanff, P, and Valette, P}
abstractNote = {The aim of this project is to investigate the effects of ionizing radiation (<10 Gy) on several parameters of gastrointestinal function: (a) regulatory peptides; (b) pancreatic and biliary secretions and (c) electrolyte and lipid transport using both gamma alone (cobalt-60) and a mixture of gamma/neutron ({gamma}/N Silene reactor) in two animal models, the rat and the pig. Preliminary data in rats following gamma irradiation (2-8 Gy) show that plasma nurotensin gastrin releasing peptide and substance P are increased in a dose dependent manner most markedly between two and four days after exposure. Intestinal brush border marker enzyme activities (sucrose and leucine amino-peptidase) were also reduced. Such differences were more marked and persisted longer after {gamma}/N irradiation (2-4 Gy: +Pb: {gamma}/:N =0.2). Following the latter type of irradiation (4 Gy) plasma cholesterol increased as well as the cholesterol/phospholipid ratio. Analysis of cholesterol distribution in lipoprotein actions revealed a large increase in cholesterol carried b High Density Lipoprotein-1 (HDL1). In the pig following either type of irradiation the volumes of both pancreatic and biliary secretions were reduced. Irradiation of pigs with either {gamma} (6 Gy) alone or {gamma}/N (6 Gy: {gamma}/N I :1) resulted in a marked decrease in both brush border (sucrase: leucine aminopeptidase) and basolateral (sodium ump` aden late cyclase) enzyme activities. Vasoactive intestinal peptide (VIP) stimulated adenylate cyclase was markedly attenuated and in addition specific VIP binding was modified as shown by a reduction in receptor affinity. The significance of the data will be discussed and the importance of a new therapeutic strategies or new biological markers of radiation-induced gastrointestinal dysfunction.}
place = {Croatia}
year = {1994}
month = {Oct}
}