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Gadodiamide injection for enhancement of MRI in the CNS. Applications, dose, field and time dependence

Abstract

Gadodiamide injection was comparable to Gd-DTPA with regard to both safety and diagnostic efficiency in the central nervous system. The contrast effect of Gd contrast agents is higher at 1.5 T than at 0.3 T both in phantoms and patients with a maximum ratio (signal lesion/signal grey matter) more than 50% higher at 1.5 T. To achieve high contrast effect, heavily T1-weighted images are important. Prolonging the TR from 400 ms to 600 ms reduced the ratio by 15-45% depending on concentration. The effective time window for imaging of BBB (Blood-Brain Barrier) damage is between 2-5 and 25-30 minutes after injection and several scans can be performed without loss of enhancement. To provide maximum detectability of BBB damage in patients, higher doses of Gd contrast media should be useful, especially at low field strengths, as the doses used clinically today do not utilize the maximum contrast effect. High-dose (0.3 mmol/kg b.w.) contrast enhanced MRI (0.3 T) with Gadodiamide injection allowed detection of significantly more and smaller metastases (i.e. BBB damage) than standard dose (0.1 mmol/kg b.w.) High dose contrast-enhanced MRI (0.3 T) did not increase the diagnostic information for the evaluation of patients with failed back surgery syndrome compared to  More>>
Authors:
Publication Date:
Oct 01, 1996
Product Type:
Thesis/Dissertation
Report Number:
LUMEDW-MEXL-1032
Reference Number:
SCA: 550602; PA: AIX-27:068120; EDB-96:146018; NTS-97:003753; SN: 96001670843
Resource Relation:
Other Information: TH: Doctoral diss. (MD).; PBD: 1996
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; NMR IMAGING; CONTRAST MEDIA; BRAIN; CENTRAL NERVOUS SYSTEM; GADOLINIUM; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE
OSTI ID:
373708
Research Organizations:
Lund Univ. (Sweden). Dept. of Diagnostic Radiology
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Other: ON: DE97601448; TRN: SE9600133068120
Availability:
INIS; OSTI as DE97601448
Submitting Site:
SWDN
Size:
38 p.
Announcement Date:

Citation Formats

Aakeson, P. Gadodiamide injection for enhancement of MRI in the CNS. Applications, dose, field and time dependence. Sweden: N. p., 1996. Web.
Aakeson, P. Gadodiamide injection for enhancement of MRI in the CNS. Applications, dose, field and time dependence. Sweden.
Aakeson, P. 1996. "Gadodiamide injection for enhancement of MRI in the CNS. Applications, dose, field and time dependence." Sweden.
@misc{etde_373708,
title = {Gadodiamide injection for enhancement of MRI in the CNS. Applications, dose, field and time dependence}
author = {Aakeson, P}
abstractNote = {Gadodiamide injection was comparable to Gd-DTPA with regard to both safety and diagnostic efficiency in the central nervous system. The contrast effect of Gd contrast agents is higher at 1.5 T than at 0.3 T both in phantoms and patients with a maximum ratio (signal lesion/signal grey matter) more than 50% higher at 1.5 T. To achieve high contrast effect, heavily T1-weighted images are important. Prolonging the TR from 400 ms to 600 ms reduced the ratio by 15-45% depending on concentration. The effective time window for imaging of BBB (Blood-Brain Barrier) damage is between 2-5 and 25-30 minutes after injection and several scans can be performed without loss of enhancement. To provide maximum detectability of BBB damage in patients, higher doses of Gd contrast media should be useful, especially at low field strengths, as the doses used clinically today do not utilize the maximum contrast effect. High-dose (0.3 mmol/kg b.w.) contrast enhanced MRI (0.3 T) with Gadodiamide injection allowed detection of significantly more and smaller metastases (i.e. BBB damage) than standard dose (0.1 mmol/kg b.w.) High dose contrast-enhanced MRI (0.3 T) did not increase the diagnostic information for the evaluation of patients with failed back surgery syndrome compared to standard dose MRI. 55 refs, 9 figs, 10 tabs.}
place = {Sweden}
year = {1996}
month = {Oct}
}