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Transdermic absorption of Melagenina II; Evaluacion de la absorcion transdermica de la Melagenina II

Abstract

The transdermic absorption of Melagenina II (MII) was evaluated. MII was a labelled with {sup 125I} by the yodogen method and purified by column chromatography with Sephadex LH-20 in ethanol: water (7:3). In vitro absorption of ({sup 125I}) - MII thought human skin was carried out in Keshary-Chien modified diffusion cells. Tape stripping method was applied after 24 hours to evaluate the accumulated activity in dermis and epidermis. In vivo assays were performed in Sprague Dawley rats to analyze absorption of MII until 24 hours after a single application and for five days a low penetrability of the drug while in vivo there were not found blood levels significantly greater than zero , nevertheless and important amount of radioactivity was found in feces and urine. The activity was concentrated mainly in the application site in both models
Authors:
Hernandez Gonzalez, I; Martinez Lopez, B; Ruiz Pena, M; Caso Pena, R [1] 
  1. Centro de Isotopos, La Habana (Cuba)
Publication Date:
Dec 31, 1997
Product Type:
Technical Report
Report Number:
CIEN-R-26-97
Reference Number:
SCA: 553006; PA: AIX-30:023574; EDB-99:057047; SN: 99002097673
Resource Relation:
Other Information: PBD: 1997
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; BIOASSAY; BIOLOGICAL MODELS; DRUGS; IODINE 121; MAN; SKIN ABSORPTION
OSTI ID:
343487
Research Organizations:
Centro de Isotopos, La Habana (Cuba)
Country of Origin:
Cuba
Language:
Spanish
Other Identifying Numbers:
Other: ON: DE99623486; TRN: CU9900033023574
Availability:
INIS; OSTI as DE99623486
Submitting Site:
INIS
Size:
5 p.
Announcement Date:
Jun 08, 1999

Citation Formats

Hernandez Gonzalez, I, Martinez Lopez, B, Ruiz Pena, M, and Caso Pena, R. Transdermic absorption of Melagenina II; Evaluacion de la absorcion transdermica de la Melagenina II. Cuba: N. p., 1997. Web.
Hernandez Gonzalez, I, Martinez Lopez, B, Ruiz Pena, M, & Caso Pena, R. Transdermic absorption of Melagenina II; Evaluacion de la absorcion transdermica de la Melagenina II. Cuba.
Hernandez Gonzalez, I, Martinez Lopez, B, Ruiz Pena, M, and Caso Pena, R. 1997. "Transdermic absorption of Melagenina II; Evaluacion de la absorcion transdermica de la Melagenina II." Cuba.
@misc{etde_343487,
title = {Transdermic absorption of Melagenina II; Evaluacion de la absorcion transdermica de la Melagenina II}
author = {Hernandez Gonzalez, I, Martinez Lopez, B, Ruiz Pena, M, and Caso Pena, R}
abstractNote = {The transdermic absorption of Melagenina II (MII) was evaluated. MII was a labelled with {sup 125I} by the yodogen method and purified by column chromatography with Sephadex LH-20 in ethanol: water (7:3). In vitro absorption of ({sup 125I}) - MII thought human skin was carried out in Keshary-Chien modified diffusion cells. Tape stripping method was applied after 24 hours to evaluate the accumulated activity in dermis and epidermis. In vivo assays were performed in Sprague Dawley rats to analyze absorption of MII until 24 hours after a single application and for five days a low penetrability of the drug while in vivo there were not found blood levels significantly greater than zero , nevertheless and important amount of radioactivity was found in feces and urine. The activity was concentrated mainly in the application site in both models}
place = {Cuba}
year = {1997}
month = {Dec}
}