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Preparation and quality control of {sup 153}Sm radiopharmaceuticals

Abstract

The paper summarizes the preparation and quality control of {sup 153}Sm-EDTMP and three {sup 153}Sm-radiosynovectomy agents. Natural and enriched Sm{sub 2}O{sub 3} (98.7% {sup 152}Sm) irradiated in RSG-GAS 30 MW reactor yielded pure and high specific activity {sup 153}Sm. Labeling of EDTMP with {sup 153}Sm was carried out by mixing {sup 153}SmCl{sub 3} solution of pH 4.0 to an EDTMP solution at room temperature then pH adjustment to 8. The {sup 153}Sm-EDTMP complex was separated from the free {sup 153}Sm{sup +3} on a Chelex 100 column. Radiochemical purity was determined by thin layer chromatography using Cellulose sheets and pyridine: ethanol: water (1: 2: 4) mixture as solvent. The {sup 153}Sm-EDTMP has been shown to be stable for two weeks. Three particulate preparations of {sup 153}Sm used for the irradiation of chronic synovitis have been studied. They are hydroxyapatite particles, human serum albumin microspheres and ferric hydroxide macroaggregates. The {sup 153}Sm-ferric hydroxide macroaggregates were prepared in a single step by coprecipitation of {sup 153}Sm in the formation of Fe(OH){sub 3}. Preparation of {sup 153}Sm-labelled hydroxyapatite particles and {sup 153}Sm-labelled albumin microspheres were carried out by {sup 153}Sm labelling of previously prepared particles. Radiolabelling efficiency were greater than 95% for hydroxyapatite particles  More>>
Authors:
Swasono, R Tamat; Widyastuti, W; Purwadi, B; Laksmi, I [1] 
  1. Radioisotope Production Center - BATAN, Jakarta (Indonesia)
Publication Date:
Oct 01, 1998
Product Type:
Conference
Report Number:
JAERI-Conf-98-015; CONF-9711223-
Reference Number:
SCA: 400703; PA: JPN-99:002130; EDB-99:037293; SN: 99002060109
Resource Relation:
Conference: 1997 workshop on the utilization of research reactors, Bandung (Indonesia), 6-13 Nov 1997; Other Information: PBD: Oct 1998; Related Information: Is Part Of Proceedings of the 1997 workshop on the utilization of research reactors; PB: 495 p.
Subject:
40 CHEMISTRY; SAMARIUM 153; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; QUALITY CONTROL; NEUTRON FLUX; IRRADIATION; SAMARIUM OXIDES; IMPURITIES; ALBUMINS; MICROSPHERES
OSTI ID:
327214
Research Organizations:
Japan Atomic Energy Research Inst., Tokyo (Japan)
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Other: ON: DE99723943; TRN: JP9902130
Availability:
OSTI as DE99723943
Submitting Site:
JPN
Size:
pp. 339-348
Announcement Date:

Citation Formats

Swasono, R Tamat, Widyastuti, W, Purwadi, B, and Laksmi, I. Preparation and quality control of {sup 153}Sm radiopharmaceuticals. Japan: N. p., 1998. Web.
Swasono, R Tamat, Widyastuti, W, Purwadi, B, & Laksmi, I. Preparation and quality control of {sup 153}Sm radiopharmaceuticals. Japan.
Swasono, R Tamat, Widyastuti, W, Purwadi, B, and Laksmi, I. 1998. "Preparation and quality control of {sup 153}Sm radiopharmaceuticals." Japan.
@misc{etde_327214,
title = {Preparation and quality control of {sup 153}Sm radiopharmaceuticals}
author = {Swasono, R Tamat, Widyastuti, W, Purwadi, B, and Laksmi, I}
abstractNote = {The paper summarizes the preparation and quality control of {sup 153}Sm-EDTMP and three {sup 153}Sm-radiosynovectomy agents. Natural and enriched Sm{sub 2}O{sub 3} (98.7% {sup 152}Sm) irradiated in RSG-GAS 30 MW reactor yielded pure and high specific activity {sup 153}Sm. Labeling of EDTMP with {sup 153}Sm was carried out by mixing {sup 153}SmCl{sub 3} solution of pH 4.0 to an EDTMP solution at room temperature then pH adjustment to 8. The {sup 153}Sm-EDTMP complex was separated from the free {sup 153}Sm{sup +3} on a Chelex 100 column. Radiochemical purity was determined by thin layer chromatography using Cellulose sheets and pyridine: ethanol: water (1: 2: 4) mixture as solvent. The {sup 153}Sm-EDTMP has been shown to be stable for two weeks. Three particulate preparations of {sup 153}Sm used for the irradiation of chronic synovitis have been studied. They are hydroxyapatite particles, human serum albumin microspheres and ferric hydroxide macroaggregates. The {sup 153}Sm-ferric hydroxide macroaggregates were prepared in a single step by coprecipitation of {sup 153}Sm in the formation of Fe(OH){sub 3}. Preparation of {sup 153}Sm-labelled hydroxyapatite particles and {sup 153}Sm-labelled albumin microspheres were carried out by {sup 153}Sm labelling of previously prepared particles. Radiolabelling efficiency were greater than 95% for hydroxyapatite particles and macroaggregates and was lower than 20% for albumin microspheres. The particle sizes were inspected using an optical microscope with a haemocytometer and micrometric ocular. (author)}
place = {Japan}
year = {1998}
month = {Oct}
}