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Interferon production and immune response induction in pathogenic rabies virus-infected mice

Journal Article:

Abstract

Pathogenic parental rabies virus strain CVS (challenge virus standard) and its apathogenic variant RV194-2 were shown to differ in their ability to induce interferon (IFN) and immune response of the host. After intracerebral inoculation. IFN and antibody production was higher in the RV194-2 virus-infected mice than in the CVS infection. The enhancement of 2-5A synthetase activity, an IFN-mediated enzyme marker, showed biochemical evidence that IFN is active in both apathogenic and pathogenic infections. On the other hand, spontaneous proliferation in vitro of thymocytes and splenocytes from CVS virus-infected mice was strongly inhibited in contrast to the RV194-2 infection. In the CVS infection, the thymocyte proliferation However, in the RV194-2 infection, the thymocyte proliferation was higher than of the splenocytes. These results suggest a better performance of T-cell response to the RV194-2 infection. This fact can be critical for an enhancement of antibody production in the apathogenic infection and subsequent virus clearance from the brain of RV194-2 virus-infected mice. (author) 1 fig., 3 tabs., 32 refs.
Authors:
Marcovistz, R; Leal, E C; De Souza Matos, D C; [1]  Tsiang, H [2] 
  1. Departamento de Immunologia, Instituto Oswaldo Cruz, Caixa Postal 926, 21045 Rio de Janeiro (Brazil)
  2. Service Rage, Istitut Pasteur, Paris (France)
Publication Date:
Aug 01, 1994
Product Type:
Journal Article
Reference Number:
SCA: 560162; 550601; PA: AIX-29:062658; EDB-99:007077; SN: 98002035015
Resource Relation:
Journal Name: Acta Virologica; Journal Volume: 38; Journal Issue: 4; Other Information: DN: 1 fig., 3 tabs., 32 refs.; PBD: Aug 1994
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; ANTIBODY FORMATION; BLOOD PLASMA; BRAIN; CELL PROLIFERATION; ENZYME ACTIVITY; EXPERIMENTAL DATA; FLUORESCENCE; IMMUNITY; IN VITRO; INTERFERON; LABELLED COMPOUNDS; LABELLING; LIGASES; MICE; PATHOGENS; RABIES; RADIOIMMUNOASSAY; RADIONUCLIDE KINETICS; STATISTICAL DATA; THYMIDINE; THYMOCYTES; TRACER TECHNIQUES; TRITIUM; UPTAKE; VIRUSES
OSTI ID:
290640
Country of Origin:
Slovakia
Language:
English
Other Identifying Numbers:
Journal ID: AVIRA2; ISSN 0001-723X; TRN: SK98K0252062658
Availability:
Available via Internet at URL http://www.savba.sk/logos/journals/ap/ap.html
Submitting Site:
INIS
Size:
pp. 193-197
Announcement Date:
Jan 14, 1999

Journal Article:

Citation Formats

Marcovistz, R, Leal, E C, De Souza Matos, D C, and Tsiang, H. Interferon production and immune response induction in pathogenic rabies virus-infected mice. Slovakia: N. p., 1994. Web.
Marcovistz, R, Leal, E C, De Souza Matos, D C, & Tsiang, H. Interferon production and immune response induction in pathogenic rabies virus-infected mice. Slovakia.
Marcovistz, R, Leal, E C, De Souza Matos, D C, and Tsiang, H. 1994. "Interferon production and immune response induction in pathogenic rabies virus-infected mice." Slovakia.
@misc{etde_290640,
title = {Interferon production and immune response induction in pathogenic rabies virus-infected mice}
author = {Marcovistz, R, Leal, E C, De Souza Matos, D C, and Tsiang, H}
abstractNote = {Pathogenic parental rabies virus strain CVS (challenge virus standard) and its apathogenic variant RV194-2 were shown to differ in their ability to induce interferon (IFN) and immune response of the host. After intracerebral inoculation. IFN and antibody production was higher in the RV194-2 virus-infected mice than in the CVS infection. The enhancement of 2-5A synthetase activity, an IFN-mediated enzyme marker, showed biochemical evidence that IFN is active in both apathogenic and pathogenic infections. On the other hand, spontaneous proliferation in vitro of thymocytes and splenocytes from CVS virus-infected mice was strongly inhibited in contrast to the RV194-2 infection. In the CVS infection, the thymocyte proliferation However, in the RV194-2 infection, the thymocyte proliferation was higher than of the splenocytes. These results suggest a better performance of T-cell response to the RV194-2 infection. This fact can be critical for an enhancement of antibody production in the apathogenic infection and subsequent virus clearance from the brain of RV194-2 virus-infected mice. (author) 1 fig., 3 tabs., 32 refs.}
journal = {Acta Virologica}
issue = {4}
volume = {38}
journal type = {AC}
place = {Slovakia}
year = {1994}
month = {Aug}
}