Abstract
Several recent epidemiological studies from Finland have suggested that sulphur dioxide (SO{sub 2}) and nitrogen dioxide (NO{sub 2}) cause adverse health effects in susceptible population groups, such as children and asthmatic patients, at much smaller concentrations than the present guideline values of the World Health Organization. One possible explanation of these findings is that the relatively long winter-time increases the sensitivity of the respiratory tract to irritant pollutants. This hypothesis is supported by experimental human and animal studies, which have shown obstruction and inflammatory changes in the conducting airways after ventilation of cold and dry air. Asthmatic patients are much more sensitive than healthy subjects to the irritating effects of cold and dry air and of air pollutants. The airways of many non-asthmatic a topic subjects are also sensitive to cold air, but these subjects are poorly defined as a potential susceptible population group to air pollutants. The aims of this project are: (1) to construct experimental human and animal facilities and protocols for short-term studies on SO{sub 2} and NO{sub 2} exposures at subfreezing temperatures, (2) to apply advanced lung function methodologies and symptom assessment for characterisation of short-term respiratory responses of asthmatic and a topic subjects to these
More>>
Salonen, R O;
Randell, J T;
Haelinen, A I;
Pennanen, A S;
[1]
Kosma, V M;
[2]
Pekkarinen, H;
[3]
Ruuskanen, J;
[4]
Tukiainen, H
[5]
- National Public Health Inst., Kuopio (Finland). Div. of Environmental Health
- Kuopio Univ. (Finland). Dept. of Pathology
- Kuopio Univ. (Finland). Dept. of Physiology
- Kuopio Univ. (Finland). Dept. of Environmental Sciences
- Kuopio Univ. (Finland). Dept. of Pulmonary Diseases
Citation Formats
Salonen, R O, Randell, J T, Haelinen, A I, Pennanen, A S, Kosma, V M, Pekkarinen, H, Ruuskanen, J, and Tukiainen, H.
Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments.
Finland: N. p.,
1995.
Web.
Salonen, R O, Randell, J T, Haelinen, A I, Pennanen, A S, Kosma, V M, Pekkarinen, H, Ruuskanen, J, & Tukiainen, H.
Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments.
Finland.
Salonen, R O, Randell, J T, Haelinen, A I, Pennanen, A S, Kosma, V M, Pekkarinen, H, Ruuskanen, J, and Tukiainen, H.
1995.
"Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments."
Finland.
@misc{etde_283537,
title = {Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments}
author = {Salonen, R O, Randell, J T, Haelinen, A I, Pennanen, A S, Kosma, V M, Pekkarinen, H, Ruuskanen, J, and Tukiainen, H}
abstractNote = {Several recent epidemiological studies from Finland have suggested that sulphur dioxide (SO{sub 2}) and nitrogen dioxide (NO{sub 2}) cause adverse health effects in susceptible population groups, such as children and asthmatic patients, at much smaller concentrations than the present guideline values of the World Health Organization. One possible explanation of these findings is that the relatively long winter-time increases the sensitivity of the respiratory tract to irritant pollutants. This hypothesis is supported by experimental human and animal studies, which have shown obstruction and inflammatory changes in the conducting airways after ventilation of cold and dry air. Asthmatic patients are much more sensitive than healthy subjects to the irritating effects of cold and dry air and of air pollutants. The airways of many non-asthmatic a topic subjects are also sensitive to cold air, but these subjects are poorly defined as a potential susceptible population group to air pollutants. The aims of this project are: (1) to construct experimental human and animal facilities and protocols for short-term studies on SO{sub 2} and NO{sub 2} exposures at subfreezing temperatures, (2) to apply advanced lung function methodologies and symptom assessment for characterisation of short-term respiratory responses of asthmatic and a topic subjects to these exposures, (3) to apply well-established pulmonary physiological, cytological and morphological methods for characterisation of short-term responses to and mechanisms of these exposures in the guinea-pig lower airways. (author)}
place = {Finland}
year = {1995}
month = {Dec}
}
title = {Acute effects of low-level sulphur dioxide and nitrogen dioxide exposures on the respiratory tract of susceptible subjects in cold environments}
author = {Salonen, R O, Randell, J T, Haelinen, A I, Pennanen, A S, Kosma, V M, Pekkarinen, H, Ruuskanen, J, and Tukiainen, H}
abstractNote = {Several recent epidemiological studies from Finland have suggested that sulphur dioxide (SO{sub 2}) and nitrogen dioxide (NO{sub 2}) cause adverse health effects in susceptible population groups, such as children and asthmatic patients, at much smaller concentrations than the present guideline values of the World Health Organization. One possible explanation of these findings is that the relatively long winter-time increases the sensitivity of the respiratory tract to irritant pollutants. This hypothesis is supported by experimental human and animal studies, which have shown obstruction and inflammatory changes in the conducting airways after ventilation of cold and dry air. Asthmatic patients are much more sensitive than healthy subjects to the irritating effects of cold and dry air and of air pollutants. The airways of many non-asthmatic a topic subjects are also sensitive to cold air, but these subjects are poorly defined as a potential susceptible population group to air pollutants. The aims of this project are: (1) to construct experimental human and animal facilities and protocols for short-term studies on SO{sub 2} and NO{sub 2} exposures at subfreezing temperatures, (2) to apply advanced lung function methodologies and symptom assessment for characterisation of short-term respiratory responses of asthmatic and a topic subjects to these exposures, (3) to apply well-established pulmonary physiological, cytological and morphological methods for characterisation of short-term responses to and mechanisms of these exposures in the guinea-pig lower airways. (author)}
place = {Finland}
year = {1995}
month = {Dec}
}