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{sup 1}H and {sup 31}P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects

Journal Article:

Abstract

White matter signal hyperintensities (WMSH) are commonly seen on MRI of elderly subjects. The purpose of this study was to characterize metabolic changes in the white matter of elderly subjects with extensive WMSH. We used water-suppressed proton ({sup 1}H) magnetic resonance spectroscopic imaging (MRSI) to compare six subjects with extensive WMSH with eight age-matched elderly subjects with minimal or absent WMSH, and phosphorus ({sup 31}P) MRSI to compare nine subjects with extensive WMSH and seven age-matched elderly subjects without extensive WMSH. Relative to region-matched tissue in elderly controls, extensive WMSH were associated with increased signal from choline-containing metabolites, no significant change of signal from N-acetylaspartate, and a trend to a decreased phosphomonoester (PME) resonance. These findings suggest that WMSH may be associated with an alteration of brain myelin phospholipids in the absence of axonal damage. There were no differences in energy phosphates, consistent with lack of ongoing brain ischemia. Within the group with extensive WMSH, PME resonance measures were significantly lower in WMSH than in contralateral normal-appearing white matter. These results provide information on pathophysiology of WMSH and a basis for comparison with WMSH in Alzheimer`s disease, vascular dementia, multiple sclerosis, and other diseases. (orig.). With 4 figs., 4 tabs.
Authors:
Constans, J M; [1]  Meyerhoff, D J; [1]  Norman, D; [2]  Fein, G; [3]  Weiner, M W [1] 
  1. Department of Veterans Affairs Medical Center and University of California Magnetic Resonance Unit, San Francisco, CA (United States)
  2. California Univ., San Francisco, CA (United States). Dept. of Radiology
  3. Department of Veterans Affairs Psychiatry Service, University of California, San Francisco, California (United States)
Publication Date:
Nov 01, 1995
Product Type:
Journal Article
Reference Number:
SCA: 550602; PA: DEN-96:0F9778; EDB-96:089453; SN: 96001596870
Resource Relation:
Journal Name: Neuroradiology; Journal Volume: 37; Journal Issue: 8; Other Information: PBD: Nov 1995
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; NMR IMAGING; BRAIN; MAGNETIC RESONANCE; SPECTROSCOPY; ISCHEMIA; PATIENTS; HYDROGEN 1; PHOSPHORUS 31; MYELIN; PHOSPHOLIPIDS; ELDERLY PEOPLE
OSTI ID:
233450
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: NRDYAB; ISSN 0028-3940; TRN: DE96F9778
Submitting Site:
DEN
Size:
pp. 615-623
Announcement Date:

Journal Article:

Citation Formats

Constans, J M, Meyerhoff, D J, Norman, D, Fein, G, and Weiner, M W. {sup 1}H and {sup 31}P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects. Germany: N. p., 1995. Web. doi:10.1007/s002340050164.
Constans, J M, Meyerhoff, D J, Norman, D, Fein, G, & Weiner, M W. {sup 1}H and {sup 31}P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects. Germany. doi:10.1007/s002340050164.
Constans, J M, Meyerhoff, D J, Norman, D, Fein, G, and Weiner, M W. 1995. "{sup 1}H and {sup 31}P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects." Germany. doi:10.1007/s002340050164. https://www.osti.gov/servlets/purl/10.1007/s002340050164.
@misc{etde_233450,
title = {{sup 1}H and {sup 31}P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects}
author = {Constans, J M, Meyerhoff, D J, Norman, D, Fein, G, and Weiner, M W}
abstractNote = {White matter signal hyperintensities (WMSH) are commonly seen on MRI of elderly subjects. The purpose of this study was to characterize metabolic changes in the white matter of elderly subjects with extensive WMSH. We used water-suppressed proton ({sup 1}H) magnetic resonance spectroscopic imaging (MRSI) to compare six subjects with extensive WMSH with eight age-matched elderly subjects with minimal or absent WMSH, and phosphorus ({sup 31}P) MRSI to compare nine subjects with extensive WMSH and seven age-matched elderly subjects without extensive WMSH. Relative to region-matched tissue in elderly controls, extensive WMSH were associated with increased signal from choline-containing metabolites, no significant change of signal from N-acetylaspartate, and a trend to a decreased phosphomonoester (PME) resonance. These findings suggest that WMSH may be associated with an alteration of brain myelin phospholipids in the absence of axonal damage. There were no differences in energy phosphates, consistent with lack of ongoing brain ischemia. Within the group with extensive WMSH, PME resonance measures were significantly lower in WMSH than in contralateral normal-appearing white matter. These results provide information on pathophysiology of WMSH and a basis for comparison with WMSH in Alzheimer`s disease, vascular dementia, multiple sclerosis, and other diseases. (orig.). With 4 figs., 4 tabs.}
doi = {10.1007/s002340050164}
journal = {Neuroradiology}
issue = {8}
volume = {37}
journal type = {AC}
place = {Germany}
year = {1995}
month = {Nov}
}