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Safety of dried sambiloto Andrographis paniculata (Burm. F.) nees gamma irradiated based on acute toxicity aspect in mice swiss webster; Keamanan sambiloto (Andrographis paniculata nees) kering yang diiradiasi gamma berdasarkan aspek toksisitas akutnya terhadap mencit galur swiss webster

Journal Article:

Abstract

Andrographis paniculata nees (Family: Acanthaceae) is a medicinal plant commonly cultivated in Asian countries. The purpose of this study was to evaluate the safety of gamma irradiated sambiloto against to animal test (mice) and to support the application of nuclear techniques for radiation pasteurization of sambiloto as health products without changing the properties. In the acute toxicity test was observed the effects of the tested material on behavioral changes, abnormalities in the function of several organs and body weight changes in animal test every day for 2 weeks. The results showed that the ethanol extract of unirradiated and irradiated with dose of 7.5 kGy) sambiloto were not toxic to mice. Lethal Dose 50 (DL{sub 50}) of ethanol extract from sambiloto unirradiated or irradiated at the dose of 7.5 kGy was > 5000 mg/kg BW. At the highest dose tested 5000 mg/kg BW mice there were no significant toxic effects and no mice that died during the experiment, therefore ethanol extracts of un irradiated and irradiated samples could be declared safe. (author)
Authors:
Katrin, Ermin; Susanto,; Hendig Winarno, E-mail: erminkk@batan.go.id [1] 
  1. Laboratorium Bahan Kesehatan PAIR - BATAN, Jl. Lebak Bulus Raya No. 49, Pasar Jumat, Jakarta 12440 (Indonesia)
Publication Date:
Aug 15, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: Jurnal Sains dan Teknologi Nuklir Indonesia; Journal Volume: 15; Journal Issue: 2; Other Information: 10 refs.; 8 tabs.; 8 figs.
Subject:
60 APPLIED LIFE SCIENCES; ACUTE IRRADIATION; ANIMALS; GAMMA RADIATION; IRRADIATION; MEDICINAL PLANTS; MICE; MICROORGANISMS; PASTEURIZATION; PLANTS; SAFETY; TOXICITY
OSTI ID:
22685766
Country of Origin:
Indonesia
Language:
Indonesian
Other Identifying Numbers:
Journal ID: ISSN 1411-3481; TRN: ID1800021034578
Submitting Site:
INIS
Size:
page(s) 103-117
Announcement Date:
May 17, 2018

Journal Article:

Citation Formats

Katrin, Ermin, Susanto,, and Hendig Winarno, E-mail: erminkk@batan.go.id. Safety of dried sambiloto Andrographis paniculata (Burm. F.) nees gamma irradiated based on acute toxicity aspect in mice swiss webster; Keamanan sambiloto (Andrographis paniculata nees) kering yang diiradiasi gamma berdasarkan aspek toksisitas akutnya terhadap mencit galur swiss webster. Indonesia: N. p., 2014. Web.
Katrin, Ermin, Susanto,, & Hendig Winarno, E-mail: erminkk@batan.go.id. Safety of dried sambiloto Andrographis paniculata (Burm. F.) nees gamma irradiated based on acute toxicity aspect in mice swiss webster; Keamanan sambiloto (Andrographis paniculata nees) kering yang diiradiasi gamma berdasarkan aspek toksisitas akutnya terhadap mencit galur swiss webster. Indonesia.
Katrin, Ermin, Susanto,, and Hendig Winarno, E-mail: erminkk@batan.go.id. 2014. "Safety of dried sambiloto Andrographis paniculata (Burm. F.) nees gamma irradiated based on acute toxicity aspect in mice swiss webster; Keamanan sambiloto (Andrographis paniculata nees) kering yang diiradiasi gamma berdasarkan aspek toksisitas akutnya terhadap mencit galur swiss webster." Indonesia.
@misc{etde_22685766,
title = {Safety of dried sambiloto Andrographis paniculata (Burm. F.) nees gamma irradiated based on acute toxicity aspect in mice swiss webster; Keamanan sambiloto (Andrographis paniculata nees) kering yang diiradiasi gamma berdasarkan aspek toksisitas akutnya terhadap mencit galur swiss webster}
author = {Katrin, Ermin, Susanto,, and Hendig Winarno, E-mail: erminkk@batan.go.id}
abstractNote = {Andrographis paniculata nees (Family: Acanthaceae) is a medicinal plant commonly cultivated in Asian countries. The purpose of this study was to evaluate the safety of gamma irradiated sambiloto against to animal test (mice) and to support the application of nuclear techniques for radiation pasteurization of sambiloto as health products without changing the properties. In the acute toxicity test was observed the effects of the tested material on behavioral changes, abnormalities in the function of several organs and body weight changes in animal test every day for 2 weeks. The results showed that the ethanol extract of unirradiated and irradiated with dose of 7.5 kGy) sambiloto were not toxic to mice. Lethal Dose 50 (DL{sub 50}) of ethanol extract from sambiloto unirradiated or irradiated at the dose of 7.5 kGy was > 5000 mg/kg BW. At the highest dose tested 5000 mg/kg BW mice there were no significant toxic effects and no mice that died during the experiment, therefore ethanol extracts of un irradiated and irradiated samples could be declared safe. (author)}
journal = {Jurnal Sains dan Teknologi Nuklir Indonesia}
issue = {2}
volume = {15}
journal type = {AC}
place = {Indonesia}
year = {2014}
month = {Aug}
}