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Water excretion mechanisms of the kidney studied in the rabbit using tritiated water during the stop-flow assay; Les mecanismes d'excretion de l'eau par le rein etudies a l'aide d'eau tritiee chez le lapin au cours de l'epreuve de diurese interrompue

Technical Report:

Abstract

The pattern of water turnover in the kidney and the mechanisms of water transfer into the urine have been studied in the rabbit using tritiated water as a tracer and the stop-flow technique. The experiments have given the following results: a) During the interruption of the diuresis, the injected tritiated water is completely exchanged with the water of the renal cortex, but the tracer does not reach the deep regions of the kidney, despite the fact that the blood circulation is maintained in these regions; this suggests that the vascular loops of the vasa recta function as a mechanism of water exchange by countercurrent. b) During the osmotic polyuria following the stop-flow period, the concentration gradient of tritiated water inside the kidney diminishes progressively. The concentration of the tracer in the urine is at all time similar to that existing in the deep medulla and the renal papilla and markedly different from that of the cortex or arterial blood. This fact shows that the molecules of water in the urine excreted do not come from either the glomerular filtrate or the convoluted tubules but from the water contained in the deep regions of the kidney. Also these results indicate that  More>>
Authors:
Morel, F.; Amiel, CI.; Falbriard, A. [1] 
  1. Commissariat a l'energie atomique et aux energies alternatives - CEA, Service de Biologie (France)
Publication Date:
Jul 01, 1960
Product Type:
Technical Report
Report Number:
CEA-R-1411
Resource Relation:
Other Information: 11 refs.; Available from the INIS Liaison Officer for France, see the 'INIS contacts' section of the INIS website for current contact and E-mail addresses: http://www.iaea.org/inis/Contacts/
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGICAL LOCALIZATION; BLOOD VESSELS; INTRAVENOUS INJECTION; KIDNEYS; LIQUID SCINTILLATION DETECTORS; NAI DETECTORS; OSMOSIS; PERMEABILITY; RABBITS; RADIONUCLIDE KINETICS; SODIUM 24; TISSUE DISTRIBUTION; TRACER TECHNIQUES; TRITIUM OXIDES; URINE
OSTI ID:
22682636
Research Organizations:
Commissariat a l'energie atomique et aux energies alternatives - CEA, Centre d'Etudes Nucleaires de Saclay, Service de Documentation, BP No.2, 91190 Gif-sur-Yvette (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR1801419031288
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
9 page(s)
Announcement Date:
May 04, 2018

Technical Report:

Citation Formats

Morel, F., Amiel, CI., and Falbriard, A. Water excretion mechanisms of the kidney studied in the rabbit using tritiated water during the stop-flow assay; Les mecanismes d'excretion de l'eau par le rein etudies a l'aide d'eau tritiee chez le lapin au cours de l'epreuve de diurese interrompue. France: N. p., 1960. Web.
Morel, F., Amiel, CI., & Falbriard, A. Water excretion mechanisms of the kidney studied in the rabbit using tritiated water during the stop-flow assay; Les mecanismes d'excretion de l'eau par le rein etudies a l'aide d'eau tritiee chez le lapin au cours de l'epreuve de diurese interrompue. France.
Morel, F., Amiel, CI., and Falbriard, A. 1960. "Water excretion mechanisms of the kidney studied in the rabbit using tritiated water during the stop-flow assay; Les mecanismes d'excretion de l'eau par le rein etudies a l'aide d'eau tritiee chez le lapin au cours de l'epreuve de diurese interrompue." France.
@misc{etde_22682636,
title = {Water excretion mechanisms of the kidney studied in the rabbit using tritiated water during the stop-flow assay; Les mecanismes d'excretion de l'eau par le rein etudies a l'aide d'eau tritiee chez le lapin au cours de l'epreuve de diurese interrompue}
author = {Morel, F., Amiel, CI., and Falbriard, A.}
abstractNote = {The pattern of water turnover in the kidney and the mechanisms of water transfer into the urine have been studied in the rabbit using tritiated water as a tracer and the stop-flow technique. The experiments have given the following results: a) During the interruption of the diuresis, the injected tritiated water is completely exchanged with the water of the renal cortex, but the tracer does not reach the deep regions of the kidney, despite the fact that the blood circulation is maintained in these regions; this suggests that the vascular loops of the vasa recta function as a mechanism of water exchange by countercurrent. b) During the osmotic polyuria following the stop-flow period, the concentration gradient of tritiated water inside the kidney diminishes progressively. The concentration of the tracer in the urine is at all time similar to that existing in the deep medulla and the renal papilla and markedly different from that of the cortex or arterial blood. This fact shows that the molecules of water in the urine excreted do not come from either the glomerular filtrate or the convoluted tubules but from the water contained in the deep regions of the kidney. Also these results indicate that the walls of the collecting ducts have a very high permeability to water diffusion. Reprint of a paper published in Revue francaise d'etudes cliniques et biologiques, Vol. IV, no. 8, p. 773-779, 1959 [French] Les modalites du renouvellement de l'eau dans le rein et les mecanismes de son passage dans l'urine ont ete etudies chez le lapin a l'aide d'eau tritiee, employee comme indicateur au cours de l'epreuve de 'diurese interrompue' (stop flow). Les experiences effectuees montrent que: a) pendant l'interruption de la diurese, l'eau tritiee injectee s'echange completement avec l'eau contenue dans le cortex renal, mais elle n'atteint pratiquement pas les regions profondes du rein, bien que la circulation sanguine y soit maintenue; cette observation suggere que les anses vasculaires des vasa recta fonctionneraient comme un dispositif d'echange d'eau par contre-courant; b) pendant la polyurie osmotique qui suit la periode d'interruption, le gradient de concentration de l'eau tritiee qui existait dans l'epaisseur du Yein s'attenue progressivement. Dans l'urine, la concentration de l'eau tritiee est a tout instant voisine de celle mesuree dans la medulla profonde et la papille du rein, et non de celle mesuree dans le cortex ou le sang arteriel. Cet equilibre prouve que les molecules d'eau de l'urine excretee ne proviennent ni du filtrat glomerulaire, ni des tubes contournes, mais ont pour origine l'eau contenue dans les regions profondes du rein. En outre, cet equilibre indique que la paroi des canaux collecteurs possede une permeabilite de diffusion pour l'eau extremement elevee. Reproduction d'un article publie dans Revue francaise d'etudes cliniques et biologiques, Vol. IV, no. 8, p. 773-779, 1959.}
place = {France}
year = {1960}
month = {Jul}
}