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Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period

Abstract

The effect of the natural antioxidant dihydroquercetin was examined on the process of free radical oxidation of serum and liver lipids of mice, after a single 4 Gy dose of γ-irradiation. The content of lipid peroxidation products reacting with thiobarbituric acid in irradiated animals receiving oral dihydroquercetin (experimental) for 155 days after irradiation was significantly lower compared with animals receiving irradiation and no antioxidant (controls). The intensity of Fe{sup 2+}-induced chemiluminescence of liver homogenates of experimental mice was lower by the end of the experiment (p < 0.001) than the chemiluminescence of liver homogenates of both control and intact animals. It is assumed that this was due to the preferential uptake of dihydroquercetin by the liver. (author)
Authors:
Teselkin, Yu. O.; Babenkova, I. V.; Tjukavkina, N. A.; Rulenko, I. A.; Kolesnik, Yu. A.; Kolhir, V. K.; Eichholz, A. A. [1] 
  1. Department of Biophysics, Russian Medical University, Ostrovityanova Street 1, Moscow 117869 (Russian Federation)
Publication Date:
Jul 01, 1998
Product Type:
Journal Article
Resource Relation:
Journal Name: PTR. Phytotherapy Research; Journal Volume: 12; Journal Issue: 7; Other Information: FAO/AGRIS record; ARN: GB1997056521; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; ANTIOXIDANTS; CHEMICAL COMPOSITION; CHEMILUMINESCENCE; COMPARATIVE EVALUATIONS; DOSES; FLAVONOIDS; GAMMA RADIATION; HOMOGENATES; IRON IONS; IRRADIATION; LIPIDS; LIVER; MICE; OPTICAL PROPERTIES; OXIDATION; RADIATION PROTECTION; RADICALS; UPTAKE; WOOD
OSTI ID:
22443788
Country of Origin:
FAO
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0951-418X; TRN: XF15A4979013329
Submitting Site:
INIS
Size:
page(s) 517-519
Announcement Date:
Mar 10, 2016

Citation Formats

Teselkin, Yu. O., Babenkova, I. V., Tjukavkina, N. A., Rulenko, I. A., Kolesnik, Yu. A., Kolhir, V. K., and Eichholz, A. A. Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period. FAO: N. p., 1998. Web. doi:10.1002/(SICI)1099-1573(199811)12:7<517::AID-PTR342>3.0.CO;2-D.
Teselkin, Yu. O., Babenkova, I. V., Tjukavkina, N. A., Rulenko, I. A., Kolesnik, Yu. A., Kolhir, V. K., & Eichholz, A. A. Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period. FAO. doi:10.1002/(SICI)1099-1573(199811)12:7<517::AID-PTR342>3.0.CO;2-D.
Teselkin, Yu. O., Babenkova, I. V., Tjukavkina, N. A., Rulenko, I. A., Kolesnik, Yu. A., Kolhir, V. K., and Eichholz, A. A. 1998. "Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period." FAO. doi:10.1002/(SICI)1099-1573(199811)12:7<517::AID-PTR342>3.0.CO;2-D. https://www.osti.gov/servlets/purl/10.1002/(SICI)1099-1573(199811)12:7<517::AID-PTR342>3.0.CO;2-D.
@misc{etde_22443788,
title = {Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period}
author = {Teselkin, Yu. O., Babenkova, I. V., Tjukavkina, N. A., Rulenko, I. A., Kolesnik, Yu. A., Kolhir, V. K., and Eichholz, A. A.}
abstractNote = {The effect of the natural antioxidant dihydroquercetin was examined on the process of free radical oxidation of serum and liver lipids of mice, after a single 4 Gy dose of γ-irradiation. The content of lipid peroxidation products reacting with thiobarbituric acid in irradiated animals receiving oral dihydroquercetin (experimental) for 155 days after irradiation was significantly lower compared with animals receiving irradiation and no antioxidant (controls). The intensity of Fe{sup 2+}-induced chemiluminescence of liver homogenates of experimental mice was lower by the end of the experiment (p < 0.001) than the chemiluminescence of liver homogenates of both control and intact animals. It is assumed that this was due to the preferential uptake of dihydroquercetin by the liver. (author)}
doi = {10.1002/(SICI)1099-1573(199811)12:7<517::AID-PTR342>3.0.CO;2-D}
journal = {PTR. Phytotherapy Research}
issue = {7}
volume = {12}
journal type = {AC}
place = {FAO}
year = {1998}
month = {Jul}
}