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Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress

Abstract

Cannabinoids, the active components of Cannabis sativa, have been shown to exert antiproliferative and proapoptotic effects on a wide spectrum of tumor cells and tissues. Of interest, cannabinoids have displayed great potency in reducing the growth of glioma tumors, one of the most aggressive CNS tumors, either in vitro or in animal experimental models curbing the growth of xenografts generated by subcutaneous or intrathecal injection of glioma cells in immune-deficient mice. Cannabinoids appear to be selective antitumoral agents as they kill glioma cells without affecting the viability of non-transformed cells. This review will summarize the anti-cancer properties that cannabinoids exert on gliomas and discuss their potential action mechanisms that appear complex, involving modulation of multiple key cell signaling pathways and induction of oxidative stress in glioma cells.
Authors:
Massi, Paola; [1]  Valenti, Marta; Solinas, Marta; Parolaro, Daniela [2] 
  1. Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan (Italy)
  2. Department of Structural and Functional Biology, Section of Pharmacology, Center of Neuroscience, University of Insubria, Via A. da Giussano 10, 20152 Busto Arsizio, Varese (Italy)
Publication Date:
May 26, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Cancers (Basel); Journal Volume: 2; Journal Issue: 2; Other Information: PMCID: PMC3835116; PMID: 24281104; PUBLISHER-ID: cancers-02-01013; OAI: oai:pubmedcentral.nih.gov:3835116; Copyright (c) 2010 by the authors; licensee MDPI, Basel, Switzerland.; This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; APOPTOSIS; GLIOMAS; IN VITRO; OXIDATION; STRESSES; TUMOR CELLS
OSTI ID:
22432442
Country of Origin:
Switzerland
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 2072-6694; TRN: CH15$0336001884
Availability:
Available from http://dx.doi.org/10.3390/cancers2021013; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835116
Submitting Site:
CHN
Size:
page(s) 1013-1026
Announcement Date:
Feb 20, 2016

Citation Formats

Massi, Paola, Valenti, Marta, Solinas, Marta, and Parolaro, Daniela. Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress. Switzerland: N. p., 2010. Web. doi:10.3390/CANCERS2021013.
Massi, Paola, Valenti, Marta, Solinas, Marta, & Parolaro, Daniela. Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress. Switzerland. doi:10.3390/CANCERS2021013.
Massi, Paola, Valenti, Marta, Solinas, Marta, and Parolaro, Daniela. 2010. "Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress." Switzerland. doi:10.3390/CANCERS2021013. https://www.osti.gov/servlets/purl/10.3390/CANCERS2021013.
@misc{etde_22432442,
title = {Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress}
author = {Massi, Paola, Valenti, Marta, Solinas, Marta, and Parolaro, Daniela}
abstractNote = {Cannabinoids, the active components of Cannabis sativa, have been shown to exert antiproliferative and proapoptotic effects on a wide spectrum of tumor cells and tissues. Of interest, cannabinoids have displayed great potency in reducing the growth of glioma tumors, one of the most aggressive CNS tumors, either in vitro or in animal experimental models curbing the growth of xenografts generated by subcutaneous or intrathecal injection of glioma cells in immune-deficient mice. Cannabinoids appear to be selective antitumoral agents as they kill glioma cells without affecting the viability of non-transformed cells. This review will summarize the anti-cancer properties that cannabinoids exert on gliomas and discuss their potential action mechanisms that appear complex, involving modulation of multiple key cell signaling pathways and induction of oxidative stress in glioma cells.}
doi = {10.3390/CANCERS2021013}
journal = {Cancers (Basel)}
issue = {2}
volume = {2}
journal type = {AC}
place = {Switzerland}
year = {2010}
month = {May}
}