You need JavaScript to view this

Gamma Ray Sterilization of Starr-Edwards Heart Valve Prostheses

Abstract

Starr-Edwards valves have normally been sterilized by exposure to ethylene oxide or by autoclaving. Patients having a prosthetic valve replacement are known to have a higher incidence of endocarditis in comparison with patients in which no prosthesis has been used. Ethylene oxide will only sterilize the surface of the valve and autoclaving has caused distortion of the polytetrafluorethylene ring. Work has been done on the effect of gamma radiation on the components of these valve prostheses and is given in detail. The bacteriological efficiency, at a total absorbed dose of 2. 5 Mrad, has been established. Thirty valves treated by this method have now been inserted and twelve patients have been examined post-operatively for a period of one to two years. All valves are working normally and there has been no evidence of blood-borne infection or malfunction of the valve. (author)
Authors:
Gibbons, J. R. P.; Alladine, M. F. [1] 
  1. London Chest Hospital, London (United Kingdom)
Publication Date:
Sep 15, 1967
Product Type:
Conference
Report Number:
IAEA-SM-92/24
Resource Relation:
Conference: Symposium on Radiosterilization of Medical Products, Budapest (Hungary), 5-9 Jun 1967, Panel Meeting on a Code of Practice for the Radiosterilization of Medical Products, Vienna (Austria), 5-9 Dec 1966; Other Information: 9 refs., 1 fig.; Related Information: In: Radiosterilization of Medical Products and Recommended Code of Practice. Proceedings of a Symposium| 481 p.
Subject:
60 APPLIED LIFE SCIENCES; ABSORBED RADIATION DOSES; AUTOCLAVES; BLOOD; COMPARATIVE EVALUATIONS; EFFICIENCY; ETHYLENE; GAMMA RADIATION; HEART; OXIDES; PATIENTS; PROSTHESES; STERILIZATION; SURFACES; VALVES
OSTI ID:
22423984
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA15M0450129911
Submitting Site:
INIS
Size:
page(s) 289-293
Announcement Date:
Jan 09, 2016

Citation Formats

Gibbons, J. R. P., and Alladine, M. F. Gamma Ray Sterilization of Starr-Edwards Heart Valve Prostheses. IAEA: N. p., 1967. Web.
Gibbons, J. R. P., & Alladine, M. F. Gamma Ray Sterilization of Starr-Edwards Heart Valve Prostheses. IAEA.
Gibbons, J. R. P., and Alladine, M. F. 1967. "Gamma Ray Sterilization of Starr-Edwards Heart Valve Prostheses." IAEA.
@misc{etde_22423984,
title = {Gamma Ray Sterilization of Starr-Edwards Heart Valve Prostheses}
author = {Gibbons, J. R. P., and Alladine, M. F.}
abstractNote = {Starr-Edwards valves have normally been sterilized by exposure to ethylene oxide or by autoclaving. Patients having a prosthetic valve replacement are known to have a higher incidence of endocarditis in comparison with patients in which no prosthesis has been used. Ethylene oxide will only sterilize the surface of the valve and autoclaving has caused distortion of the polytetrafluorethylene ring. Work has been done on the effect of gamma radiation on the components of these valve prostheses and is given in detail. The bacteriological efficiency, at a total absorbed dose of 2. 5 Mrad, has been established. Thirty valves treated by this method have now been inserted and twelve patients have been examined post-operatively for a period of one to two years. All valves are working normally and there has been no evidence of blood-borne infection or malfunction of the valve. (author)}
place = {IAEA}
year = {1967}
month = {Sep}
}