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The Effects of Cobalt-60 Gamma Radiation on Vitamin B{sub 6} and Folic Acid; Effets des rayons gamma (cobalt-60) sur la vitamine B{sub 6} et l’acide folique

Conference:

Abstract

A study has been made of the behaviour of pyridoxine and folic acid, including structural changes, after {sup 60}Co gamma irradiation. The irradiation of pyridoxine (vitamin B{sub 6}) and folic acid in aqueous solutions leads to their partial or total destruction, depending on the dose. The irradiation of pyridoxine and folic acid in the solid state mainly results in the elimination of hydrogen atoms (free radicals). After dissolving the irradiated samples in acid solutions it was observed that the irradiated molecule was renewed through replacement of the eliminated hydrogen atoms, which depend on the pH-value of the solution. This gives the possibility of sterilizing both pyridoxine and folic acid in the solid state by irradiation at 2 Mrad. Most of the radiolysis products of pyridoxine and folic acid irradiated in solution and in the solid state have been separated and identified by means of chromatography (paper and thin layer) and cellulose column electrophoresis. Electron spin resonance was used to determine the concentration and nature of the free radicals after irradiation of pyridoxine and folic acid in the solid state. (author) [French] On a Studie le comportement de la pyridoxine et de l'acide folique apres exposition aux rayons gamma ({sup 60}Co)  More>>
Authors:
Galatzeanu, I.; Antoni, F. [1] 
  1. International Atomic Energy Agency, Vienna (Austria)
Publication Date:
Sep 15, 1967
Product Type:
Conference
Report Number:
IAEA-SM-92/7
Resource Relation:
Conference: Symposium on Radiosterilization of Medical Products, Budapest (Hungary), 5-9 Jun 1967, Panel Meeting on a Code of Practice for the Radiosterilization of Medical Products, Vienna (Austria), 5-9 Dec 1966; Other Information: 10 refs., 15 figs., 2 tabs.; Related Information: In: Radiosterilization of Medical Products and Recommended Code of Practice. Proceedings of a Symposium| 481 p.
Subject:
60 APPLIED LIFE SCIENCES; AQUEOUS SOLUTIONS; CELLULOSE; CHROMATOGRAPHY; COBALT 60; CONCENTRATION RATIO; ELECTRON SPIN RESONANCE; ELECTROPHORESIS; FOLIC ACID; GAMMA RADIATION; HYDROGEN; IRRADIATION; PH VALUE; PYRIDOXINE; RADIATION DOSES; RADICALS; RADIOLYSIS; THIN FILMS
OSTI ID:
22423960
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
French
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA15M0426129887
Submitting Site:
INIS
Size:
page(s) 33-48
Announcement Date:
Jan 09, 2016

Conference:

Citation Formats

Galatzeanu, I., and Antoni, F. The Effects of Cobalt-60 Gamma Radiation on Vitamin B{sub 6} and Folic Acid; Effets des rayons gamma (cobalt-60) sur la vitamine B{sub 6} et l’acide folique. IAEA: N. p., 1967. Web.
Galatzeanu, I., & Antoni, F. The Effects of Cobalt-60 Gamma Radiation on Vitamin B{sub 6} and Folic Acid; Effets des rayons gamma (cobalt-60) sur la vitamine B{sub 6} et l’acide folique. IAEA.
Galatzeanu, I., and Antoni, F. 1967. "The Effects of Cobalt-60 Gamma Radiation on Vitamin B{sub 6} and Folic Acid; Effets des rayons gamma (cobalt-60) sur la vitamine B{sub 6} et l’acide folique." IAEA.
@misc{etde_22423960,
title = {The Effects of Cobalt-60 Gamma Radiation on Vitamin B{sub 6} and Folic Acid; Effets des rayons gamma (cobalt-60) sur la vitamine B{sub 6} et l’acide folique}
author = {Galatzeanu, I., and Antoni, F.}
abstractNote = {A study has been made of the behaviour of pyridoxine and folic acid, including structural changes, after {sup 60}Co gamma irradiation. The irradiation of pyridoxine (vitamin B{sub 6}) and folic acid in aqueous solutions leads to their partial or total destruction, depending on the dose. The irradiation of pyridoxine and folic acid in the solid state mainly results in the elimination of hydrogen atoms (free radicals). After dissolving the irradiated samples in acid solutions it was observed that the irradiated molecule was renewed through replacement of the eliminated hydrogen atoms, which depend on the pH-value of the solution. This gives the possibility of sterilizing both pyridoxine and folic acid in the solid state by irradiation at 2 Mrad. Most of the radiolysis products of pyridoxine and folic acid irradiated in solution and in the solid state have been separated and identified by means of chromatography (paper and thin layer) and cellulose column electrophoresis. Electron spin resonance was used to determine the concentration and nature of the free radicals after irradiation of pyridoxine and folic acid in the solid state. (author) [French] On a Studie le comportement de la pyridoxine et de l'acide folique apres exposition aux rayons gamma ({sup 60}Co) et les changements dans leurs structures. L'irradiation de la pyridoxine (Vitamine B{sub 6}) et de l'acide folique en solutions aqueuses enttarne leur destruction partielle ou totale selon la dose. L'irradiation de la pyridoxine et de l'acide folique á l'etat solide enttarne principalement l'elimination d'atomes d'hydrogene (radicaux libres). Par dissolution des echanrilions irradies dans des solutions acides, on a observe un renouvellement de la molecule irradiee par remplacement des atomes d'hydrogene elimines qui est fonction du pH de la solution, ce qui permet de radiosteriliser a 2 Mrad á l'etat solide tant la pyridoxine que l'acide folique. On a separe et identifie la majorite des produits de radiolyse de la pyridoxine et de l'acide folique irradies en solution et á l'etat solide, a l'aide de la Chromatographie sur papier et en couches minces et de Yelectrophorese sur colonnes de cellulose. La resonance de spin des electrons a etc appliquee pour la determination de la concentration et de la nature des radicaux libres apres irradiation de la pyridoxine et de l'acide folique a l'etat solide. (author)}
place = {IAEA}
year = {1967}
month = {Sep}
}