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Modification of bone marrow radiosensitivity by medicinal plant extracts

Abstract

Withaferin A (WA), a steroidal lactone, and Plumbagin (Pi), a naphthoquinone, from the roots of Withania somnifera and Plumbage rosea, respectively, have been shows to possess growth inhibitory and radiosensitizing effects on experimental mouse tumours. An aqueous extract of the leaves of Ocimum sanctum (OE) was found to protect mice against radiation lethality. Therefore, the radiomodifying effects of the above plant products on the bone marrow of the adult Swiss mouse was studied. Single doses of WA (30 mg kg{sup -1}) or P1 (5 mg kg{sup -1}) were injected intraperitoneally tip) and OE (10 mg kg{sup -1}) was injected ip once daily for five consecutive days. Administration of extracts was followed by 2 Gy whole body gamma irradiation. Bone marrow stem cell survival was studied by an exogenous spleen colony unit (CFU-S) assay. The effects of WA and P1 were compared with that of cyclophosphamide (CP) and radioprotection by OE was compared with that of WR-2721 (WR). Radiation reduced the CFU-S to less than 50% of normal. WA, CP and P1 significantly enhanced this effect and reduced the CFU-S to almost the same extent (to <20% of normal), although individually WA and P1 were less cytotoxic than CP. These results  More>>
Authors:
Ganasoundari, A.; Zare, S. M.; Uma Devi, P. [1] 
  1. Department of Radiobiology, Kasturba Medical College, Manipal 576 119 (India)
Publication Date:
Jul 01, 1997
Product Type:
Journal Article
Resource Relation:
Journal Name: British Journal of Radiology; Journal Volume: 70; Journal Issue: 834; Other Information: FAO/AGRIS record; ARN: GB1997039829; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; BONE MARROW; ENDOXAN; GAMMA RADIATION; LACTONES; MEDICINAL PLANTS; MICE; RADIATION PROTECTION; RADIOSENSITIVITY; RADIOTHERAPY; SPLEEN; STEM CELLS; TOXICITY
OSTI ID:
22420892
Country of Origin:
FAO
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0007-1285; TRN: XF15A1258126788
Availability:
Also available on-line: http://www.birpublications.org/doi/pdf/10.1259/bjr.70.834.9227253
Submitting Site:
INIS
Size:
page(s) 599-602
Announcement Date:
Jan 06, 2016

Citation Formats

Ganasoundari, A., Zare, S. M., and Uma Devi, P. Modification of bone marrow radiosensitivity by medicinal plant extracts. FAO: N. p., 1997. Web. doi:10.1259/bjr.70.834.9227253.
Ganasoundari, A., Zare, S. M., & Uma Devi, P. Modification of bone marrow radiosensitivity by medicinal plant extracts. FAO. doi:10.1259/bjr.70.834.9227253.
Ganasoundari, A., Zare, S. M., and Uma Devi, P. 1997. "Modification of bone marrow radiosensitivity by medicinal plant extracts." FAO. doi:10.1259/bjr.70.834.9227253. https://www.osti.gov/servlets/purl/10.1259/bjr.70.834.9227253.
@misc{etde_22420892,
title = {Modification of bone marrow radiosensitivity by medicinal plant extracts}
author = {Ganasoundari, A., Zare, S. M., and Uma Devi, P.}
abstractNote = {Withaferin A (WA), a steroidal lactone, and Plumbagin (Pi), a naphthoquinone, from the roots of Withania somnifera and Plumbage rosea, respectively, have been shows to possess growth inhibitory and radiosensitizing effects on experimental mouse tumours. An aqueous extract of the leaves of Ocimum sanctum (OE) was found to protect mice against radiation lethality. Therefore, the radiomodifying effects of the above plant products on the bone marrow of the adult Swiss mouse was studied. Single doses of WA (30 mg kg{sup -1}) or P1 (5 mg kg{sup -1}) were injected intraperitoneally tip) and OE (10 mg kg{sup -1}) was injected ip once daily for five consecutive days. Administration of extracts was followed by 2 Gy whole body gamma irradiation. Bone marrow stem cell survival was studied by an exogenous spleen colony unit (CFU-S) assay. The effects of WA and P1 were compared with that of cyclophosphamide (CP) and radioprotection by OE was compared with that of WR-2721 (WR). Radiation reduced the CFU-S to less than 50% of normal. WA, CP and P1 significantly enhanced this effect and reduced the CFU-S to almost the same extent (to <20% of normal), although individually WA and P1 were less cytotoxic than CP. These results indicate that radiosensitization by WE and P1 is not tumour specific. OE significantly increased CFU-S compared with radiotherapy (RT) alone. OE + RT gave a higher stem cell survival (p < 0.05) than that produced by WR + RT. While WR alone had a toxic effect, OE treatment showed no such effect, suggesting that the latter may have an advantage over WR in clinical application. (author)}
doi = {10.1259/bjr.70.834.9227253}
journal = {British Journal of Radiology}
issue = {834}
volume = {70}
journal type = {AC}
place = {FAO}
year = {1997}
month = {Jul}
}