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Evaluation of sodium diclofenac release using natural rubber latex as carrier

Abstract

Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controlling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release  More>>
Authors:
Aielo, Patricia B.; Borges, Felipe A.; Romeira, Karoline M.; Herculano, Rondinelli D., E-mail: rond@assis.unesp.br; [1]  Miranda, Matheus Carlos Romeiro; [2]  Arruda, Larisa B. de; Lisboa Filho, Paulo Noronha; Drago, Bruno de C. [3] 
  1. Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Assis, SP (Brazil). Fac. de Ciencias e Letras. Dept. de Ciencias Biologicas
  2. Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Araraquara, SP (Brazil). Inst. de Quimica
  3. Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Bauru, SP (Brazil). Fac. de Ciencias. Dept. de Fisica
Publication Date:
Aug 15, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: Materials Research (Sao Carlos, SP); Journal Volume: 17; Journal Issue: Suppl.1; Conference: CBECIMAT 2012: 20. Brazilian congress of engineering and science of materials, Joinville, SC (Brazil), 4-8 Nov 2012
Subject:
36 MATERIALS SCIENCE; BIOLOGICAL MATERIALS; CARRIERS; DRUGS; IN VITRO; INFRARED SPECTRA; KINETICS; MEMBRANES; NATURAL RUBBER; SCANNING ELECTRON MICROSCOPY; SODIUM; X-RAY DIFFRACTION
OSTI ID:
22331479
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1516-1439; TRN: BR1500403037763
Availability:
Available from http://www.scielo.br/pdf/mr/v17s1/aop_matres_187313.pdf
Submitting Site:
BRN
Size:
page(s) 146-152
Announcement Date:
May 13, 2015

Citation Formats

Aielo, Patricia B., Borges, Felipe A., Romeira, Karoline M., Herculano, Rondinelli D., E-mail: rond@assis.unesp.br, Miranda, Matheus Carlos Romeiro, Arruda, Larisa B. de, Lisboa Filho, Paulo Noronha, and Drago, Bruno de C. Evaluation of sodium diclofenac release using natural rubber latex as carrier. Brazil: N. p., 2014. Web. doi:10.1590/S1516-14392014005000010.
Aielo, Patricia B., Borges, Felipe A., Romeira, Karoline M., Herculano, Rondinelli D., E-mail: rond@assis.unesp.br, Miranda, Matheus Carlos Romeiro, Arruda, Larisa B. de, Lisboa Filho, Paulo Noronha, & Drago, Bruno de C. Evaluation of sodium diclofenac release using natural rubber latex as carrier. Brazil. doi:10.1590/S1516-14392014005000010.
Aielo, Patricia B., Borges, Felipe A., Romeira, Karoline M., Herculano, Rondinelli D., E-mail: rond@assis.unesp.br, Miranda, Matheus Carlos Romeiro, Arruda, Larisa B. de, Lisboa Filho, Paulo Noronha, and Drago, Bruno de C. 2014. "Evaluation of sodium diclofenac release using natural rubber latex as carrier." Brazil. doi:10.1590/S1516-14392014005000010. https://www.osti.gov/servlets/purl/10.1590/S1516-14392014005000010.
@misc{etde_22331479,
title = {Evaluation of sodium diclofenac release using natural rubber latex as carrier}
author = {Aielo, Patricia B., Borges, Felipe A., Romeira, Karoline M., Herculano, Rondinelli D., E-mail: rond@assis.unesp.br, Miranda, Matheus Carlos Romeiro, Arruda, Larisa B. de, Lisboa Filho, Paulo Noronha, and Drago, Bruno de C.}
abstractNote = {Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controlling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications.(author)}
doi = {10.1590/S1516-14392014005000010}
journal = {Materials Research (Sao Carlos, SP)}
issue = {Suppl.1}
volume = {17}
journal type = {AC}
place = {Brazil}
year = {2014}
month = {Aug}
}