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Pre-clinical research in small animals using radiotherapy technology. A bidirectional translational approach

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Abstract

For translational cancer research, pre-clinical in-vivo studies using small animals have become indispensable in bridging the gap between in-vitro cell experiments and clinical implementation. When setting up such small animal experiments, various biological, technical and methodical aspects have to be considered. In this work we present a comprehensive topical review based on relevant publications on irradiation techniques used for pre-clinical cancer research in mice and rats. Clinical radiotherapy treatment devices for the application of external beam radiotherapy and brachytherapy as well as dedicated research irradiation devices are feasible for small animal irradiation depending on the animal model and the experimental goals. In this work, appropriate solutions for the technological transfer of human radiation oncology to small animal radiation research are summarised. Additionally, important information concerning the experimental design is provided such that reliable and clinically relevant results can be attained.
Authors:
Tillner, Falk; Buetof, Rebecca; [1]  Helmholtz-Zentrum Dresden-Rossendorf, Dresden; [2]  Technische Univ. Dresden (Germany). Dept. of Radiation Oncology]; Thute, Prasad; [1]  Helmholtz-Zentrum Dresden-Rossendorf, Dresden; [2]  Krause, Mechthild; [1]  Helmholtz-Zentrum Dresden-Rossendorf, Dresden; [2]  Technische Univ. Dresden (Germany). Dept. of Radiation Oncology; German Cancer Consortium, Dresden; [3]  German Cancer Research Center (DKFZ), Heidelberg (Germany)]; Enghardt, Wolfgang; [1]  Helmholtz-Zentrum Dresden-Rossendorf, Dresden; [2]  Technische Univ. Dresden (Germany). Dept. of Radiation Oncology; Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Radiooncology]
  1. Technische Univ. Dresden (Germany). OncoRay - National Center for Radiation Research in Oncology
  2. Germany
  3. DKTK; Germany
Publication Date:
Jul 01, 2014
DOI:
https://doi.org/10.1016/j.zemedi.2014.07.004
Product Type:
Journal Article
Resource Relation:
Journal Name: Zeitschrift fuer Medizinische Physik; Journal Volume: 24; Journal Issue: 4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL RADIATION EFFECTS; BRACHYTHERAPY; CARCINOMAS; CELL CULTURES; COMPUTERIZED TOMOGRAPHY; CT-GUIDED RADIOTHERAPY; EXTERNAL BEAM RADIATION THERAPY; GAMMA RADIATION; IN VITRO; IN VIVO; IRIDIUM 192; IRRADIATION DEVICES; MICE; RADIOBIOLOGY; RATS; SURGERY; TISSUE CULTURES; TRANSPLANTS; X RADIATION
OSTI ID:
22324144
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0939-3889; TRN: DE15F1255030358
Submitting Site:
DE
Size:
page(s) 335-351
Announcement Date:
Apr 09, 2015

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Tillner, Falk, Buetof, Rebecca, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology], Thute, Prasad, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Krause, Mechthild, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, German Cancer Consortium, Dresden, German Cancer Research Center (DKFZ), Heidelberg (Germany)], Enghardt, Wolfgang, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Radiooncology]. Pre-clinical research in small animals using radiotherapy technology. A bidirectional translational approach. Germany: N. p., 2014. Web. doi:10.1016/j.zemedi.2014.07.004.
Tillner, Falk, Buetof, Rebecca, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology], Thute, Prasad, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Krause, Mechthild, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, German Cancer Consortium, Dresden, German Cancer Research Center (DKFZ), Heidelberg (Germany)], Enghardt, Wolfgang, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, & Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Radiooncology]. Pre-clinical research in small animals using radiotherapy technology. A bidirectional translational approach. Germany. https://doi.org/10.1016/j.zemedi.2014.07.004
Tillner, Falk, Buetof, Rebecca, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology], Thute, Prasad, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Krause, Mechthild, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, German Cancer Consortium, Dresden, German Cancer Research Center (DKFZ), Heidelberg (Germany)], Enghardt, Wolfgang, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Radiooncology]. 2014. "Pre-clinical research in small animals using radiotherapy technology. A bidirectional translational approach." Germany. https://doi.org/10.1016/j.zemedi.2014.07.004.
@misc{etde_22324144,
title = {Pre-clinical research in small animals using radiotherapy technology. A bidirectional translational approach}
 author = {Tillner, Falk, Buetof, Rebecca, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology], Thute, Prasad, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Krause, Mechthild, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, German Cancer Consortium, Dresden, German Cancer Research Center (DKFZ), Heidelberg (Germany)], Enghardt, Wolfgang, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Technische Univ. Dresden (Germany). Dept. of Radiation Oncology, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Radiooncology]}
 abstractNote = {For translational cancer research, pre-clinical in-vivo studies using small animals have become indispensable in bridging the gap between in-vitro cell experiments and clinical implementation. When setting up such small animal experiments, various biological, technical and methodical aspects have to be considered. In this work we present a comprehensive topical review based on relevant publications on irradiation techniques used for pre-clinical cancer research in mice and rats. Clinical radiotherapy treatment devices for the application of external beam radiotherapy and brachytherapy as well as dedicated research irradiation devices are feasible for small animal irradiation depending on the animal model and the experimental goals. In this work, appropriate solutions for the technological transfer of human radiation oncology to small animal radiation research are summarised. Additionally, important information concerning the experimental design is provided such that reliable and clinically relevant results can be attained.}
 doi = {10.1016/j.zemedi.2014.07.004}
 journal = []
 issue = {4}
 volume = {24}
 journal type = {AC}
 place = {Germany}
 year = {2014}
 month = {Jul}
 }