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Modified Chitosan Nanoparticle by Radiation Synthesis: An Approach to Drug Delivery and Bio-Based Additive for Biomedical Applications

Abstract

Self-assembly chitosan nanoparticle (CsNP) has been synthesized via radiolytic methodology using gamma irradiation. The systematic condition in preparation was studied. Chitosan nanoparticle was modified using hydrophobic core of deoxycholic acid (DC) and stearyl methacrylate (SMA) and the hydrophilic shell of polyethylene glycol monomethacrylate (PEG). The hydrophobic/hydrophilic CsNP was prepared for drug carrier molecule. The SMA-CsNP was also conjugated with pyperidine, hindered amine light stabilizer function, to achieve a bio-based additive for biomedical plastic. (author)
Authors:
Pasanphan, W.; Rimdusit, P.; Rattanawongwiboon, T.; Choofong, S., E-mail: sciwvm@ku.ac.th, E-mail: pwanvimol@yahoo.com [1] 
  1. Kasetsart University, Faculty of Science, Department of Applied Radiation and Isotopes, 50 Phahonyothin Road, Chatuchak, Bangkok 1090 (Thailand)
Publication Date:
Jul 01, 2010
Product Type:
Conference
Report Number:
IAEA-RC-1124.2
Resource Relation:
Conference: 2. research coordination meeting on nanoscale radiation engineering of advanced materials for potential biomedical applications, Paris (France), 15-19 Nov 2010; Other Information: 15 refs., 11 figs.; Related Information: In: Report of the 2nd RCM on nanoscale radiation engineering of advanced materials for potential biomedical applications| 236 p.
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; AMINES; AMINO ACIDS; DRUGS; GAMMA RADIATION; METHACRYLATES; MOLECULES; NANOPARTICLES; NANOSTRUCTURES; OLIGOSACCHARIDES; PLASTICS; POLYETHYLENE GLYCOLS; RADIOLYSIS; SYNTHESIS; VISIBLE RADIATION
OSTI ID:
22309190
Research Organizations:
International Atomic Energy Agency, Division of Physical and Chemical Sciences, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA14M3053015363
Availability:
Available from INIS in electronic form. Also available on-line: http://www-naweb.iaea.org/napc/iachem/working_materials/RC-1124-2_report_complete.pdf
Submitting Site:
INIS
Size:
page(s) 188-198
Announcement Date:
Feb 28, 2015

Citation Formats

Pasanphan, W., Rimdusit, P., Rattanawongwiboon, T., and Choofong, S., E-mail: sciwvm@ku.ac.th, E-mail: pwanvimol@yahoo.com. Modified Chitosan Nanoparticle by Radiation Synthesis: An Approach to Drug Delivery and Bio-Based Additive for Biomedical Applications. IAEA: N. p., 2010. Web.
Pasanphan, W., Rimdusit, P., Rattanawongwiboon, T., & Choofong, S., E-mail: sciwvm@ku.ac.th, E-mail: pwanvimol@yahoo.com. Modified Chitosan Nanoparticle by Radiation Synthesis: An Approach to Drug Delivery and Bio-Based Additive for Biomedical Applications. IAEA.
Pasanphan, W., Rimdusit, P., Rattanawongwiboon, T., and Choofong, S., E-mail: sciwvm@ku.ac.th, E-mail: pwanvimol@yahoo.com. 2010. "Modified Chitosan Nanoparticle by Radiation Synthesis: An Approach to Drug Delivery and Bio-Based Additive for Biomedical Applications." IAEA.
@misc{etde_22309190,
title = {Modified Chitosan Nanoparticle by Radiation Synthesis: An Approach to Drug Delivery and Bio-Based Additive for Biomedical Applications}
author = {Pasanphan, W., Rimdusit, P., Rattanawongwiboon, T., and Choofong, S., E-mail: sciwvm@ku.ac.th, E-mail: pwanvimol@yahoo.com}
abstractNote = {Self-assembly chitosan nanoparticle (CsNP) has been synthesized via radiolytic methodology using gamma irradiation. The systematic condition in preparation was studied. Chitosan nanoparticle was modified using hydrophobic core of deoxycholic acid (DC) and stearyl methacrylate (SMA) and the hydrophilic shell of polyethylene glycol monomethacrylate (PEG). The hydrophobic/hydrophilic CsNP was prepared for drug carrier molecule. The SMA-CsNP was also conjugated with pyperidine, hindered amine light stabilizer function, to achieve a bio-based additive for biomedical plastic. (author)}
place = {IAEA}
year = {2010}
month = {Jul}
}