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PH-Sensitive Nanogels Synthesised by Radiation-Induced Cross-Linking of Hydrogen-Bonded Interpolymer Complexes in Aqueous Solution

Abstract

Nanogels, i.e., internally cross-linked hydrophilic polymeric particles of sub-micron sizes, gained much interest over the last years due to their possible application as components of advanced type of medicines, like drug carriers. It is expected that they can facilitate distribution and delivery of different types of biologically active substances (including proteins, peptides and oligonucleotides) in a controlled way within the human body. Nanogels and their bigger analogues – microgels, are mainly synthesised through free-radical cross-linking polymerization of monomers. This synthetic routine can be carried out in solution but more often emulsion techniques are preferred (mini- or microemulsion) due to easier size control and exclusion of the macrogelation process. Additionally, surfactant-free emulsion polymerization (SFEP) is the method of choice for the preparation of temperature-sensitive particles, mainly based on poly(N-isopropylacrylamide).Nanogels were also successfully prepared by intramolecular cross-linking of single macromolecules. More recently, covalent stabilization was utilized to obtain the self-assembled structures like micelles of amphiphilic block copolymers, held by relatively weak physical interactions. Due to low stability of these polymolecular systems against dilution or temperature changes, different chemistry-based strategies to turn them into permanent nanopaticles were proposed in the literature (e.g., independent stabilization of a core or a shell of the micelles)
Authors:
Ulanski, P.; Kadłubowski, S.; Henke, A.; Olejnik, A. K.; Rokita, B.; Wach, R.; Rosiak, J.M., E-mail: slawekka@mitr.p.lodz.pl [1] 
  1. Technical University of Lodz, Wroblewskiego 15, 93-590 Lodz (Poland)
Publication Date:
Jul 01, 2010
Product Type:
Conference
Report Number:
IAEA-RC-1124.2
Resource Relation:
Conference: 2. research coordination meeting on nanoscale radiation engineering of advanced materials for potential biomedical applications, Paris (France), 15-19 Nov 2010; Other Information: 44 refs., 5 figs., 1 tab.; Related Information: In: Report of the 2nd RCM on nanoscale radiation engineering of advanced materials for potential biomedical applications| 236 p.
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; AQUEOUS SOLUTIONS; COPOLYMERS; COVALENCE; CROSS-LINKING; DILUTION; DRUGS; HYDROGEN; MEDICINE; MICROEMULSIONS; MONOMERS; OLIGONUCLEOTIDES; PARTICLES; PEPTIDES; PH VALUE; STABILIZATION; SYNTHESIS
OSTI ID:
22309188
Research Organizations:
International Atomic Energy Agency, Division of Physical and Chemical Sciences, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Contract Number:
Project 507/6.PR UE/2008/7 No. 503/6.PR UE/2007/7; Contract IAEA RC 15473 TC-POL802
Other Identifying Numbers:
TRN: XA14M3051015361
Availability:
Available from INIS in electronic form. Also available on-line: http://www-naweb.iaea.org/napc/iachem/working_materials/RC-1124-2_report_complete.pdf
Submitting Site:
INIS
Size:
page(s) 164-174
Announcement Date:
Feb 28, 2015

Citation Formats

Ulanski, P., Kadłubowski, S., Henke, A., Olejnik, A. K., Rokita, B., Wach, R., and Rosiak, J.M., E-mail: slawekka@mitr.p.lodz.pl. PH-Sensitive Nanogels Synthesised by Radiation-Induced Cross-Linking of Hydrogen-Bonded Interpolymer Complexes in Aqueous Solution. IAEA: N. p., 2010. Web.
Ulanski, P., Kadłubowski, S., Henke, A., Olejnik, A. K., Rokita, B., Wach, R., & Rosiak, J.M., E-mail: slawekka@mitr.p.lodz.pl. PH-Sensitive Nanogels Synthesised by Radiation-Induced Cross-Linking of Hydrogen-Bonded Interpolymer Complexes in Aqueous Solution. IAEA.
Ulanski, P., Kadłubowski, S., Henke, A., Olejnik, A. K., Rokita, B., Wach, R., and Rosiak, J.M., E-mail: slawekka@mitr.p.lodz.pl. 2010. "PH-Sensitive Nanogels Synthesised by Radiation-Induced Cross-Linking of Hydrogen-Bonded Interpolymer Complexes in Aqueous Solution." IAEA.
@misc{etde_22309188,
title = {PH-Sensitive Nanogels Synthesised by Radiation-Induced Cross-Linking of Hydrogen-Bonded Interpolymer Complexes in Aqueous Solution}
author = {Ulanski, P., Kadłubowski, S., Henke, A., Olejnik, A. K., Rokita, B., Wach, R., and Rosiak, J.M., E-mail: slawekka@mitr.p.lodz.pl}
abstractNote = {Nanogels, i.e., internally cross-linked hydrophilic polymeric particles of sub-micron sizes, gained much interest over the last years due to their possible application as components of advanced type of medicines, like drug carriers. It is expected that they can facilitate distribution and delivery of different types of biologically active substances (including proteins, peptides and oligonucleotides) in a controlled way within the human body. Nanogels and their bigger analogues – microgels, are mainly synthesised through free-radical cross-linking polymerization of monomers. This synthetic routine can be carried out in solution but more often emulsion techniques are preferred (mini- or microemulsion) due to easier size control and exclusion of the macrogelation process. Additionally, surfactant-free emulsion polymerization (SFEP) is the method of choice for the preparation of temperature-sensitive particles, mainly based on poly(N-isopropylacrylamide).Nanogels were also successfully prepared by intramolecular cross-linking of single macromolecules. More recently, covalent stabilization was utilized to obtain the self-assembled structures like micelles of amphiphilic block copolymers, held by relatively weak physical interactions. Due to low stability of these polymolecular systems against dilution or temperature changes, different chemistry-based strategies to turn them into permanent nanopaticles were proposed in the literature (e.g., independent stabilization of a core or a shell of the micelles)}
place = {IAEA}
year = {2010}
month = {Jul}
}