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Nanoparticle-based drug delivery systems: promising approaches against infections

Abstract

Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections. (author)
Authors:
Ranghar, Shweta; Sirohi, Parul; [1]  Verma, Pritam; Agarwal, Vishnu [2] 
  1. Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad (India)
  2. Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad (India)
Publication Date:
Mar 15, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: Brazilian Archives of Biology and Technology; Journal Volume: 57; Journal Issue: 2
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 77 NANOSCIENCE AND NANOTECHNOLOGY; ADRENAL GLANDS; ANTIMICROBIAL AGENTS; INFECTIOUS DISEASES; MALE GENITALS; METALS; NANOSTRUCTURES; REVIEWS
OSTI ID:
22289282
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1516-8913; TRN: BR1400668110748
Availability:
Available from http://www.scielo.br/pdf/babt/v57n2/cd_941.pdf
Submitting Site:
BRN
Size:
page(s) 209-222
Announcement Date:
Jan 01, 2015

Citation Formats

Ranghar, Shweta, Sirohi, Parul, Verma, Pritam, and Agarwal, Vishnu. Nanoparticle-based drug delivery systems: promising approaches against infections. Brazil: N. p., 2014. Web. doi:10.1590/S1516-89132013005000011.
Ranghar, Shweta, Sirohi, Parul, Verma, Pritam, & Agarwal, Vishnu. Nanoparticle-based drug delivery systems: promising approaches against infections. Brazil. doi:10.1590/S1516-89132013005000011.
Ranghar, Shweta, Sirohi, Parul, Verma, Pritam, and Agarwal, Vishnu. 2014. "Nanoparticle-based drug delivery systems: promising approaches against infections." Brazil. doi:10.1590/S1516-89132013005000011. https://www.osti.gov/servlets/purl/10.1590/S1516-89132013005000011.
@misc{etde_22289282,
title = {Nanoparticle-based drug delivery systems: promising approaches against infections}
author = {Ranghar, Shweta, Sirohi, Parul, Verma, Pritam, and Agarwal, Vishnu}
abstractNote = {Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections. (author)}
doi = {10.1590/S1516-89132013005000011}
journal = {Brazilian Archives of Biology and Technology}
issue = {2}
volume = {57}
journal type = {AC}
place = {Brazil}
year = {2014}
month = {Mar}
}