Abstract
Purpose: The purpose of this study was to investigate the role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) in clinical stage II-III breast cancer patients with pN0. Methods and Materials: We retrospectively identified 417 clinical stage II-III breast cancer patients who achieved an ypN0 at surgery after receiving NAC between 1998 and 2009. Of these, 151 patients underwent mastectomy after NAC. The effect of PMRT on disease-free survival (DFS), locoregional recurrence-free survival (LRRFS), and overall survival (OS) was evaluated by multivariate analysis including known prognostic factors using the Kaplan-Meier method and compared using the log–rank test and Cox proportional regression analysis. Results: Of the 151 patients who underwent mastectomy, 105 (69.5%) received PMRT and 46 patients (30.5%) did not. At a median follow-up of 59 months, 5 patients (3.3%) developed LRR (8 sites of recurrence) and 14 patients (9.3%) developed distant metastasis. The 5-year DFS, LRRFS, and OS rates were 91.2, 98.1, and 93.3% with PMRT and 83.0%, 92.3%, and 89.9% without PMRT, respectively (all P values not significant). By univariate analysis, only age (≤40 vs >40 years) was significantly associated with decreased DFS (P=.027). By multivariate analysis, age (≤40 vs >40 years) and pathologic T stage (0-is
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Shim, Su Jung;
[1]
Park, Won;
[2]
Huh, Seung Jae;
Choi, Doo Ho;
[2]
Shin, Kyung Hwan;
[3]
Lee, Nam Kwon;
[3]
Department of Radiation Oncology, Korea Medical Center, Korea University, School of Medicine, Seoul (Korea, Republic of)];
Suh, Chang-Ok;
Keum, Ki Chang;
Kim, Yong Bae;
[4]
Ahn, Seung Do;
Kim, Su Ssan;
[5]
Ha, Sung W.;
Chie, Eui Kyu;
Kim, Kyubo;
[6]
Shin, Hyun Soo;
[7]
Kim, Jin Hee;
[8]
Lee, Hyung-Sik
[9]
- Department of Radiation Oncology, Eulji General Hospital, College of Medicine, Eulji University, Seoul (Korea, Republic of)
- Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)
- Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)
- Department of Radiation Oncology, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)
- Department of Radiation Oncology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul (Korea, Republic of)
- Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of)
- Department of Radiation Oncology, Bundang CHA Hospital, School of Medicine, CHA University, Seongnam (Korea, Republic of)
- Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu (Korea, Republic of)
- Department of Radiation Oncology, Dong-A University Hospital, Dong-A University School of Medicine, Busan (Korea, Republic of)
Citation Formats
Shim, Su Jung, Park, Won, Huh, Seung Jae, Choi, Doo Ho, Shin, Kyung Hwan, Lee, Nam Kwon, Department of Radiation Oncology, Korea Medical Center, Korea University, School of Medicine, Seoul (Korea, Republic of)], Suh, Chang-Ok, Keum, Ki Chang, Kim, Yong Bae, Ahn, Seung Do, Kim, Su Ssan, Ha, Sung W., Chie, Eui Kyu, Kim, Kyubo, Shin, Hyun Soo, Kim, Jin Hee, and Lee, Hyung-Sik.
The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy in Clinical Stage II-III Breast Cancer Patients With pN0: A Multicenter, Retrospective Study (KROG 12-05).
United States: N. p.,
2014.
Web.
doi:10.1016/J.IJROBP.2013.09.021.
Shim, Su Jung, Park, Won, Huh, Seung Jae, Choi, Doo Ho, Shin, Kyung Hwan, Lee, Nam Kwon, Department of Radiation Oncology, Korea Medical Center, Korea University, School of Medicine, Seoul (Korea, Republic of)], Suh, Chang-Ok, Keum, Ki Chang, Kim, Yong Bae, Ahn, Seung Do, Kim, Su Ssan, Ha, Sung W., Chie, Eui Kyu, Kim, Kyubo, Shin, Hyun Soo, Kim, Jin Hee, & Lee, Hyung-Sik.
The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy in Clinical Stage II-III Breast Cancer Patients With pN0: A Multicenter, Retrospective Study (KROG 12-05).
United States.
https://doi.org/10.1016/J.IJROBP.2013.09.021
Shim, Su Jung, Park, Won, Huh, Seung Jae, Choi, Doo Ho, Shin, Kyung Hwan, Lee, Nam Kwon, Department of Radiation Oncology, Korea Medical Center, Korea University, School of Medicine, Seoul (Korea, Republic of)], Suh, Chang-Ok, Keum, Ki Chang, Kim, Yong Bae, Ahn, Seung Do, Kim, Su Ssan, Ha, Sung W., Chie, Eui Kyu, Kim, Kyubo, Shin, Hyun Soo, Kim, Jin Hee, and Lee, Hyung-Sik.
2014.
"The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy in Clinical Stage II-III Breast Cancer Patients With pN0: A Multicenter, Retrospective Study (KROG 12-05)."
United States.
https://doi.org/10.1016/J.IJROBP.2013.09.021.
@misc{etde_22283314,
title = {The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy in Clinical Stage II-III Breast Cancer Patients With pN0: A Multicenter, Retrospective Study (KROG 12-05)}
author = {Shim, Su Jung, Park, Won, Huh, Seung Jae, Choi, Doo Ho, Shin, Kyung Hwan, Lee, Nam Kwon, Department of Radiation Oncology, Korea Medical Center, Korea University, School of Medicine, Seoul (Korea, Republic of)], Suh, Chang-Ok, Keum, Ki Chang, Kim, Yong Bae, Ahn, Seung Do, Kim, Su Ssan, Ha, Sung W., Chie, Eui Kyu, Kim, Kyubo, Shin, Hyun Soo, Kim, Jin Hee, and Lee, Hyung-Sik}
abstractNote = {Purpose: The purpose of this study was to investigate the role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) in clinical stage II-III breast cancer patients with pN0. Methods and Materials: We retrospectively identified 417 clinical stage II-III breast cancer patients who achieved an ypN0 at surgery after receiving NAC between 1998 and 2009. Of these, 151 patients underwent mastectomy after NAC. The effect of PMRT on disease-free survival (DFS), locoregional recurrence-free survival (LRRFS), and overall survival (OS) was evaluated by multivariate analysis including known prognostic factors using the Kaplan-Meier method and compared using the log–rank test and Cox proportional regression analysis. Results: Of the 151 patients who underwent mastectomy, 105 (69.5%) received PMRT and 46 patients (30.5%) did not. At a median follow-up of 59 months, 5 patients (3.3%) developed LRR (8 sites of recurrence) and 14 patients (9.3%) developed distant metastasis. The 5-year DFS, LRRFS, and OS rates were 91.2, 98.1, and 93.3% with PMRT and 83.0%, 92.3%, and 89.9% without PMRT, respectively (all P values not significant). By univariate analysis, only age (≤40 vs >40 years) was significantly associated with decreased DFS (P=.027). By multivariate analysis, age (≤40 vs >40 years) and pathologic T stage (0-is vs 1 vs 2-4) were significant prognostic factors affecting DFS (hazard ratio [HR] 0.353, 95% confidence interval [CI] 0.135-0.928, P=.035; HR 2.223, 95% CI 1.074-4.604, P=.031, respectively). PMRT showed no correlation with a difference in DFS, LRRFS, or OS by multivariate analysis. Conclusions: PMRT might not be necessary for pN0 patients after NAC, regardless of clinical stage. Prospective randomized clinical trial data are needed to assess whether PMRT can be safely omitted in pN0 patients after NAC and mastectomy for clinical stage II-III breast cancer.}
doi = {10.1016/J.IJROBP.2013.09.021}
journal = []
issue = {1}
volume = {88}
journal type = {AC}
place = {United States}
year = {2014}
month = {Jan}
}
title = {The Role of Postmastectomy Radiation Therapy After Neoadjuvant Chemotherapy in Clinical Stage II-III Breast Cancer Patients With pN0: A Multicenter, Retrospective Study (KROG 12-05)}
author = {Shim, Su Jung, Park, Won, Huh, Seung Jae, Choi, Doo Ho, Shin, Kyung Hwan, Lee, Nam Kwon, Department of Radiation Oncology, Korea Medical Center, Korea University, School of Medicine, Seoul (Korea, Republic of)], Suh, Chang-Ok, Keum, Ki Chang, Kim, Yong Bae, Ahn, Seung Do, Kim, Su Ssan, Ha, Sung W., Chie, Eui Kyu, Kim, Kyubo, Shin, Hyun Soo, Kim, Jin Hee, and Lee, Hyung-Sik}
abstractNote = {Purpose: The purpose of this study was to investigate the role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) in clinical stage II-III breast cancer patients with pN0. Methods and Materials: We retrospectively identified 417 clinical stage II-III breast cancer patients who achieved an ypN0 at surgery after receiving NAC between 1998 and 2009. Of these, 151 patients underwent mastectomy after NAC. The effect of PMRT on disease-free survival (DFS), locoregional recurrence-free survival (LRRFS), and overall survival (OS) was evaluated by multivariate analysis including known prognostic factors using the Kaplan-Meier method and compared using the log–rank test and Cox proportional regression analysis. Results: Of the 151 patients who underwent mastectomy, 105 (69.5%) received PMRT and 46 patients (30.5%) did not. At a median follow-up of 59 months, 5 patients (3.3%) developed LRR (8 sites of recurrence) and 14 patients (9.3%) developed distant metastasis. The 5-year DFS, LRRFS, and OS rates were 91.2, 98.1, and 93.3% with PMRT and 83.0%, 92.3%, and 89.9% without PMRT, respectively (all P values not significant). By univariate analysis, only age (≤40 vs >40 years) was significantly associated with decreased DFS (P=.027). By multivariate analysis, age (≤40 vs >40 years) and pathologic T stage (0-is vs 1 vs 2-4) were significant prognostic factors affecting DFS (hazard ratio [HR] 0.353, 95% confidence interval [CI] 0.135-0.928, P=.035; HR 2.223, 95% CI 1.074-4.604, P=.031, respectively). PMRT showed no correlation with a difference in DFS, LRRFS, or OS by multivariate analysis. Conclusions: PMRT might not be necessary for pN0 patients after NAC, regardless of clinical stage. Prospective randomized clinical trial data are needed to assess whether PMRT can be safely omitted in pN0 patients after NAC and mastectomy for clinical stage II-III breast cancer.}
doi = {10.1016/J.IJROBP.2013.09.021}
journal = []
issue = {1}
volume = {88}
journal type = {AC}
place = {United States}
year = {2014}
month = {Jan}
}