Abstract
The aim of this study was to analyse the scientific evidence published to date on the potential effects on neurodevelopment and behavioural disorders in children exposed to arsenic, cadmium and manganese and to quantify the magnitude of the effect on neurodevelopment by pooling the results of the different studies. We conducted a systematic review of original articles from January 2000 until March 2012, that evaluate the effects on neurodevelopment and behavioural disorders due to pre or post natal exposure to arsenic, cadmium and manganese in children up to 16 years of age. We also conducted a meta-analysis assessing the effects of exposure to arsenic and manganese on neurodevelopment. Forty-one articles that evaluated the effects of metallic elements on neurodevelopment and behavioural disorders met the inclusion criteria: 18 examined arsenic, 6 cadmium and 17 manganese. Most studies evaluating exposure to arsenic (13 of 18) and manganese (14 of 17) reported a significant negative effect on neurodevelopment and behavioural disorders. Only two studies that evaluated exposure to cadmium found an association with neurodevelopmental or behavioural disorders. The results of our meta-analysis suggest that a 50% increase of arsenic levels in urine would be associated with a 0.4 decrease in the intelligence quotient
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Rodríguez-Barranco, Miguel;
[1]
Lacasaña, Marina;
[1]
CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)];
Aguilar-Garduño, Clemente;
[2]
Centre Superior d'Investigació en Salut Pública, Conselleria de Sanitat, Valencia (Spain)];
Alguacil, Juan;
[2]
Department of Environmental Biology and Public Health, University of Huelva, Huelva (Spain)];
Gil, Fernando;
[3]
González-Alzaga, Beatriz;
[1]
Rojas-García, Antonio
[2]
- Andalusian School of Public Health (EASP), Granada (Spain)
- CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)
- Department of Legal Medicine and Toxicology, University of Granada, Granada (Spain)
Citation Formats
Rodríguez-Barranco, Miguel, Lacasaña, Marina, CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)], Aguilar-Garduño, Clemente, Centre Superior d'Investigació en Salut Pública, Conselleria de Sanitat, Valencia (Spain)], Alguacil, Juan, Department of Environmental Biology and Public Health, University of Huelva, Huelva (Spain)], Gil, Fernando, González-Alzaga, Beatriz, and Rojas-García, Antonio.
Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis.
Netherlands: N. p.,
2013.
Web.
doi:10.1016/J.SCITOTENV.2013.03.047.
Rodríguez-Barranco, Miguel, Lacasaña, Marina, CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)], Aguilar-Garduño, Clemente, Centre Superior d'Investigació en Salut Pública, Conselleria de Sanitat, Valencia (Spain)], Alguacil, Juan, Department of Environmental Biology and Public Health, University of Huelva, Huelva (Spain)], Gil, Fernando, González-Alzaga, Beatriz, & Rojas-García, Antonio.
Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis.
Netherlands.
https://doi.org/10.1016/J.SCITOTENV.2013.03.047
Rodríguez-Barranco, Miguel, Lacasaña, Marina, CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)], Aguilar-Garduño, Clemente, Centre Superior d'Investigació en Salut Pública, Conselleria de Sanitat, Valencia (Spain)], Alguacil, Juan, Department of Environmental Biology and Public Health, University of Huelva, Huelva (Spain)], Gil, Fernando, González-Alzaga, Beatriz, and Rojas-García, Antonio.
2013.
"Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis."
Netherlands.
https://doi.org/10.1016/J.SCITOTENV.2013.03.047.
@misc{etde_22277181,
title = {Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis}
author = {Rodríguez-Barranco, Miguel, Lacasaña, Marina, CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)], Aguilar-Garduño, Clemente, Centre Superior d'Investigació en Salut Pública, Conselleria de Sanitat, Valencia (Spain)], Alguacil, Juan, Department of Environmental Biology and Public Health, University of Huelva, Huelva (Spain)], Gil, Fernando, González-Alzaga, Beatriz, and Rojas-García, Antonio}
abstractNote = {The aim of this study was to analyse the scientific evidence published to date on the potential effects on neurodevelopment and behavioural disorders in children exposed to arsenic, cadmium and manganese and to quantify the magnitude of the effect on neurodevelopment by pooling the results of the different studies. We conducted a systematic review of original articles from January 2000 until March 2012, that evaluate the effects on neurodevelopment and behavioural disorders due to pre or post natal exposure to arsenic, cadmium and manganese in children up to 16 years of age. We also conducted a meta-analysis assessing the effects of exposure to arsenic and manganese on neurodevelopment. Forty-one articles that evaluated the effects of metallic elements on neurodevelopment and behavioural disorders met the inclusion criteria: 18 examined arsenic, 6 cadmium and 17 manganese. Most studies evaluating exposure to arsenic (13 of 18) and manganese (14 of 17) reported a significant negative effect on neurodevelopment and behavioural disorders. Only two studies that evaluated exposure to cadmium found an association with neurodevelopmental or behavioural disorders. The results of our meta-analysis suggest that a 50% increase of arsenic levels in urine would be associated with a 0.4 decrease in the intelligence quotient (IQ) of children aged 5–15 years. Moreover a 50% increase of manganese levels in hair would be associated with a decrease of 0.7 points in the IQ of children aged 6–13 years. There is evidence that relates arsenic and manganese exposure with neurodevelopmental problems in children, but there is little information on cadmium exposure. Few studies have evaluated behavioural disorders due to exposure to these compounds, and manganese is the only one for which there is more evidence of the existence of association with attention deficit disorder with hyperactivity. - Highlights: • We evaluated the association between As, Cd and Mn with neurodevelopment in children. • A 50% increase in As levels is associated with a 0.4 decrease in the IQ of children. • A 50% increase in Mn levels is associated with a 0.7 decrease in the IQ of children. • There is evidence of association between Mn exposure with attention deficit disorder with hyperactivity.}
doi = {10.1016/J.SCITOTENV.2013.03.047}
journal = []
volume = {454-455}
journal type = {AC}
place = {Netherlands}
year = {2013}
month = {Jun}
}
title = {Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis}
author = {Rodríguez-Barranco, Miguel, Lacasaña, Marina, CIBER of Epidemiology and Public Health (CIBERESP), Madrid (Spain)], Aguilar-Garduño, Clemente, Centre Superior d'Investigació en Salut Pública, Conselleria de Sanitat, Valencia (Spain)], Alguacil, Juan, Department of Environmental Biology and Public Health, University of Huelva, Huelva (Spain)], Gil, Fernando, González-Alzaga, Beatriz, and Rojas-García, Antonio}
abstractNote = {The aim of this study was to analyse the scientific evidence published to date on the potential effects on neurodevelopment and behavioural disorders in children exposed to arsenic, cadmium and manganese and to quantify the magnitude of the effect on neurodevelopment by pooling the results of the different studies. We conducted a systematic review of original articles from January 2000 until March 2012, that evaluate the effects on neurodevelopment and behavioural disorders due to pre or post natal exposure to arsenic, cadmium and manganese in children up to 16 years of age. We also conducted a meta-analysis assessing the effects of exposure to arsenic and manganese on neurodevelopment. Forty-one articles that evaluated the effects of metallic elements on neurodevelopment and behavioural disorders met the inclusion criteria: 18 examined arsenic, 6 cadmium and 17 manganese. Most studies evaluating exposure to arsenic (13 of 18) and manganese (14 of 17) reported a significant negative effect on neurodevelopment and behavioural disorders. Only two studies that evaluated exposure to cadmium found an association with neurodevelopmental or behavioural disorders. The results of our meta-analysis suggest that a 50% increase of arsenic levels in urine would be associated with a 0.4 decrease in the intelligence quotient (IQ) of children aged 5–15 years. Moreover a 50% increase of manganese levels in hair would be associated with a decrease of 0.7 points in the IQ of children aged 6–13 years. There is evidence that relates arsenic and manganese exposure with neurodevelopmental problems in children, but there is little information on cadmium exposure. Few studies have evaluated behavioural disorders due to exposure to these compounds, and manganese is the only one for which there is more evidence of the existence of association with attention deficit disorder with hyperactivity. - Highlights: • We evaluated the association between As, Cd and Mn with neurodevelopment in children. • A 50% increase in As levels is associated with a 0.4 decrease in the IQ of children. • A 50% increase in Mn levels is associated with a 0.7 decrease in the IQ of children. • There is evidence of association between Mn exposure with attention deficit disorder with hyperactivity.}
doi = {10.1016/J.SCITOTENV.2013.03.047}
journal = []
volume = {454-455}
journal type = {AC}
place = {Netherlands}
year = {2013}
month = {Jun}
}