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Porous Polymer Drug-Eluting Coating Prepared by Radiation Induced Polymerization

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Abstract

Drug-eluting stents have several advantages over bare metal implants. They eliminate restenosis, the main drawback of bare metal stents. In addition the locally delivered drug is more effective and causes less side-effects. However in some cases dangerous stent thrombosis, inflammatory and allergy reactions were observed after their implantation, which first of all related to the drug-eluting coating. This project is aimed to develop a novel biocompatible nanoporous polymer layer by radiation induced polymerization that is capable of holding and eluting drugs and promotes endothelization after the release of the drug. (author)
Authors:
Veres, M.; Tóth, S.; Koós, M.; [1]  Beiler, B. [2] 
  1. Research Institute for Solid State Physics and Optics, Budapest (Hungary)
  2. Institute of Isotopes, HAS, Budapest (Hungary)
Publication Date:
Jul 01, 2009
Product Type:
Conference
Report Number:
IAEA-RC-1124.1
Resource Relation:
Conference: 1. RCM on nanoscale radiation engineering of advanced materials for potential biomedical applications, Vienna (Austria), 30 Mar - 3 Apr 2009; Other Information: 28 refs., 7 figs.; Related Information: In: Report of the 1st RCM on ''Nanoscale radiation engineering of advanced materials for potential biomedical applications''. Working document| 161 p.
Subject:
60 APPLIED LIFE SCIENCES; 36 MATERIALS SCIENCE; DRUGS; IMPLANTS; INFLAMMATION; POLYMERIZATION; POLYMERS; POROUS MATERIALS; SIDE EFFECTS; THROMBOSIS
OSTI ID:
22270109
Research Organizations:
International Atomic Energy Agency, Division of Physical and Chemical Sciences, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA14M3121091341
Availability:
Available from INIS in electronic form. Also available on-line: http://www-naweb.iaea.org/napc/iachem/working_materials/RC-1124-1_report_complete.pdf
Submitting Site:
INIS
Size:
page(s) 71-79
Announcement Date:
Oct 22, 2014

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Citation Formats

Veres, M., Tóth, S., Koós, M., and Beiler, B. Porous Polymer Drug-Eluting Coating Prepared by Radiation Induced Polymerization. IAEA: N. p., 2009. Web.
Veres, M., Tóth, S., Koós, M., & Beiler, B. Porous Polymer Drug-Eluting Coating Prepared by Radiation Induced Polymerization. IAEA.
Veres, M., Tóth, S., Koós, M., and Beiler, B. 2009. "Porous Polymer Drug-Eluting Coating Prepared by Radiation Induced Polymerization." IAEA.
@misc{etde_22270109,
title = {Porous Polymer Drug-Eluting Coating Prepared by Radiation Induced Polymerization}
 author = {Veres, M., Tóth, S., Koós, M., and Beiler, B.}
 abstractNote = {Drug-eluting stents have several advantages over bare metal implants. They eliminate restenosis, the main drawback of bare metal stents. In addition the locally delivered drug is more effective and causes less side-effects. However in some cases dangerous stent thrombosis, inflammatory and allergy reactions were observed after their implantation, which first of all related to the drug-eluting coating. This project is aimed to develop a novel biocompatible nanoporous polymer layer by radiation induced polymerization that is capable of holding and eluting drugs and promotes endothelization after the release of the drug. (author)}
 place = {IAEA}
 year = {2009}
 month = {Jul}
 }