Abstract
Papain is used as an ingredient in various enzymatic debridement preparations. Those paste-like preparations are based on water solution and usually are sterilized by radiation. As a consequence, there is a major decrease in papain activity. Papain containing preparations are used in chronic wounds treatment in order to clean and remove the necrotic tissue. However FDA (2008) is taking an action against such products due to severe adverse events reported in patients which were submitted to papain treatments. Thus, the main goal of this proposal is to develop encapsulated papain containing membranes based on hydrogels and silicone rubber in an attempt to achieve a controllable distribution of size and delivery profile, a toxicity reduction and provide stability towards radiation processing through nanoencapsulation with cyclodextrins, which may also provide protection to the enzyme against radiation induced radiolysis. (author)
Lugão, A. B.;
Varca, G. H.C.;
Paiffer, F.;
Mathor, M. B.;
Lopes, P. S.;
Rogero, S.;
Rogero, J. R.
[1]
- Comissão Nacional de Energia Nuclear (CNEN), Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo (Brazil)
Citation Formats
Lugão, A. B., Varca, G. H.C., Paiffer, F., Mathor, M. B., Lopes, P. S., Rogero, S., and Rogero, J. R.
Encapsulation and Nano-Encapsulation of Papain Active Sites to Enhance Radiolityc Stability and Decrease Toxicity.
IAEA: N. p.,
2009.
Web.
Lugão, A. B., Varca, G. H.C., Paiffer, F., Mathor, M. B., Lopes, P. S., Rogero, S., & Rogero, J. R.
Encapsulation and Nano-Encapsulation of Papain Active Sites to Enhance Radiolityc Stability and Decrease Toxicity.
IAEA.
Lugão, A. B., Varca, G. H.C., Paiffer, F., Mathor, M. B., Lopes, P. S., Rogero, S., and Rogero, J. R.
2009.
"Encapsulation and Nano-Encapsulation of Papain Active Sites to Enhance Radiolityc Stability and Decrease Toxicity."
IAEA.
@misc{etde_22270105,
title = {Encapsulation and Nano-Encapsulation of Papain Active Sites to Enhance Radiolityc Stability and Decrease Toxicity}
author = {Lugão, A. B., Varca, G. H.C., Paiffer, F., Mathor, M. B., Lopes, P. S., Rogero, S., and Rogero, J. R.}
abstractNote = {Papain is used as an ingredient in various enzymatic debridement preparations. Those paste-like preparations are based on water solution and usually are sterilized by radiation. As a consequence, there is a major decrease in papain activity. Papain containing preparations are used in chronic wounds treatment in order to clean and remove the necrotic tissue. However FDA (2008) is taking an action against such products due to severe adverse events reported in patients which were submitted to papain treatments. Thus, the main goal of this proposal is to develop encapsulated papain containing membranes based on hydrogels and silicone rubber in an attempt to achieve a controllable distribution of size and delivery profile, a toxicity reduction and provide stability towards radiation processing through nanoencapsulation with cyclodextrins, which may also provide protection to the enzyme against radiation induced radiolysis. (author)}
place = {IAEA}
year = {2009}
month = {Jul}
}
title = {Encapsulation and Nano-Encapsulation of Papain Active Sites to Enhance Radiolityc Stability and Decrease Toxicity}
author = {Lugão, A. B., Varca, G. H.C., Paiffer, F., Mathor, M. B., Lopes, P. S., Rogero, S., and Rogero, J. R.}
abstractNote = {Papain is used as an ingredient in various enzymatic debridement preparations. Those paste-like preparations are based on water solution and usually are sterilized by radiation. As a consequence, there is a major decrease in papain activity. Papain containing preparations are used in chronic wounds treatment in order to clean and remove the necrotic tissue. However FDA (2008) is taking an action against such products due to severe adverse events reported in patients which were submitted to papain treatments. Thus, the main goal of this proposal is to develop encapsulated papain containing membranes based on hydrogels and silicone rubber in an attempt to achieve a controllable distribution of size and delivery profile, a toxicity reduction and provide stability towards radiation processing through nanoencapsulation with cyclodextrins, which may also provide protection to the enzyme against radiation induced radiolysis. (author)}
place = {IAEA}
year = {2009}
month = {Jul}
}