Abstract
Various experiments were carried out for the separation of {sup 90}Y from {sup 90}Sr using colloid formation behavior of {sup 90}Y in basic pH range. When the acidic solution of {sup 90}Sr/{sup 90}Y was treated with NaOH and passed through a small glass wool column, more than 95% {sup 90}Y was retained on glass wool, which was further washed with 0.1 M NaOH. The {sup 90}Y was extracted in 1 M HCl. Radionuclidic purity was determined by half life measurement. The contamination of parent was less than 0.0001%. Similarly when the colloid was passed through membrane filter more than 95% {sup 90}Y was retained which was recovered by 1 M HCl. The contamination of {sup 90}Sr was less than 0.0001%. The stock solution of {sup 90}Sr/{sup 90}Y in NH{sub 4}OH/NaOH was again passed through Millipore filter paper or glass wool after one week. The retention of 90Y was insignificant. The equilibrium mixture of {sup 90}Sr/{sup 90}Y was acidified with HCl and again precipitated with addition of NH{sub 4}OH or NaOH. The basic solution was passed through the Millipore filter or glass wool. More than 90% activity of {sup 90}Y was retained, which was finally extracted in 1 M HCl It
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Mansur, M. S.;
Mushtaq, A.
[1]
- Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad (Pakistan)
Citation Formats
Mansur, M. S., and Mushtaq, A.
Country report: Pakistan. Second Research Co-ordination Meeting on Development of Radiopharmaceuticals Based on {sup 188}Re and {sup 90}Y for Radionuclide Therapy, 22-26 March 2010, Vienna.
IAEA: N. p.,
2010.
Web.
Mansur, M. S., & Mushtaq, A.
Country report: Pakistan. Second Research Co-ordination Meeting on Development of Radiopharmaceuticals Based on {sup 188}Re and {sup 90}Y for Radionuclide Therapy, 22-26 March 2010, Vienna.
IAEA.
Mansur, M. S., and Mushtaq, A.
2010.
"Country report: Pakistan. Second Research Co-ordination Meeting on Development of Radiopharmaceuticals Based on {sup 188}Re and {sup 90}Y for Radionuclide Therapy, 22-26 March 2010, Vienna."
IAEA.
@misc{etde_22270096,
title = {Country report: Pakistan. Second Research Co-ordination Meeting on Development of Radiopharmaceuticals Based on {sup 188}Re and {sup 90}Y for Radionuclide Therapy, 22-26 March 2010, Vienna}
author = {Mansur, M. S., and Mushtaq, A.}
abstractNote = {Various experiments were carried out for the separation of {sup 90}Y from {sup 90}Sr using colloid formation behavior of {sup 90}Y in basic pH range. When the acidic solution of {sup 90}Sr/{sup 90}Y was treated with NaOH and passed through a small glass wool column, more than 95% {sup 90}Y was retained on glass wool, which was further washed with 0.1 M NaOH. The {sup 90}Y was extracted in 1 M HCl. Radionuclidic purity was determined by half life measurement. The contamination of parent was less than 0.0001%. Similarly when the colloid was passed through membrane filter more than 95% {sup 90}Y was retained which was recovered by 1 M HCl. The contamination of {sup 90}Sr was less than 0.0001%. The stock solution of {sup 90}Sr/{sup 90}Y in NH{sub 4}OH/NaOH was again passed through Millipore filter paper or glass wool after one week. The retention of 90Y was insignificant. The equilibrium mixture of {sup 90}Sr/{sup 90}Y was acidified with HCl and again precipitated with addition of NH{sub 4}OH or NaOH. The basic solution was passed through the Millipore filter or glass wool. More than 90% activity of {sup 90}Y was retained, which was finally extracted in 1 M HCl It was concluded that for recovery of {sup 90}Y from {sup 90}Sr by colloid formation, the acidic solution of {sup 90}Sr/{sup 90}Y shall be freshly precipitated by NH{sub 4}OH or NaOH. It was also observed that the adsorption of {sup 90}Y was quite high when the {sup 90}Sr solution was left in a glass vial for the growth of {sup 90}Y. However it can be easily extracted after keeping it in boiling water bath for few minutes. The separated {sup 90}Y via colloid formation was used for the labeling of EDTMP. Labeling efficiency of {sup 90}Y-EDTMP was more than 98%.}
place = {IAEA}
year = {2010}
month = {Jul}
}
title = {Country report: Pakistan. Second Research Co-ordination Meeting on Development of Radiopharmaceuticals Based on {sup 188}Re and {sup 90}Y for Radionuclide Therapy, 22-26 March 2010, Vienna}
author = {Mansur, M. S., and Mushtaq, A.}
abstractNote = {Various experiments were carried out for the separation of {sup 90}Y from {sup 90}Sr using colloid formation behavior of {sup 90}Y in basic pH range. When the acidic solution of {sup 90}Sr/{sup 90}Y was treated with NaOH and passed through a small glass wool column, more than 95% {sup 90}Y was retained on glass wool, which was further washed with 0.1 M NaOH. The {sup 90}Y was extracted in 1 M HCl. Radionuclidic purity was determined by half life measurement. The contamination of parent was less than 0.0001%. Similarly when the colloid was passed through membrane filter more than 95% {sup 90}Y was retained which was recovered by 1 M HCl. The contamination of {sup 90}Sr was less than 0.0001%. The stock solution of {sup 90}Sr/{sup 90}Y in NH{sub 4}OH/NaOH was again passed through Millipore filter paper or glass wool after one week. The retention of 90Y was insignificant. The equilibrium mixture of {sup 90}Sr/{sup 90}Y was acidified with HCl and again precipitated with addition of NH{sub 4}OH or NaOH. The basic solution was passed through the Millipore filter or glass wool. More than 90% activity of {sup 90}Y was retained, which was finally extracted in 1 M HCl It was concluded that for recovery of {sup 90}Y from {sup 90}Sr by colloid formation, the acidic solution of {sup 90}Sr/{sup 90}Y shall be freshly precipitated by NH{sub 4}OH or NaOH. It was also observed that the adsorption of {sup 90}Y was quite high when the {sup 90}Sr solution was left in a glass vial for the growth of {sup 90}Y. However it can be easily extracted after keeping it in boiling water bath for few minutes. The separated {sup 90}Y via colloid formation was used for the labeling of EDTMP. Labeling efficiency of {sup 90}Y-EDTMP was more than 98%.}
place = {IAEA}
year = {2010}
month = {Jul}
}